PMID- 36899345
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230315
IS  - 1471-2458 (Electronic)
IS  - 1471-2458 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 10
TI  - Mediating effect of BMI on the relation of dietary patterns and glycemic control 
      inT2DM patients: results from China community-based cross-sectional study.
PG  - 468
LID - 10.1186/s12889-022-14856-5 [doi]
LID - 468
AB  - OBJECTIVE: To analyze the effects of different dietary types on in type 2 
      diabetes mellitus (T2DM) and determine the mediating effects of Body Mass Index 
      (BMI) on dietary type with Fasting Plasma Glucose (FPG), Glycosylated Hemoglobin 
      (HbA1c) on the associations in T2DM. METHODS: Data of community-based 
      cross-sectional study with 9602 participants including 3623 men and 5979 women 
      were collected from the project 'Comprehensive Research in prevention and Control 
      of Diabetes mellitus (CRPCD)' conducted by Jiangsu Center for Disease Control and 
      Prevention in 2018. The dietary data were collected from a food frequency 
      qualitative questionnaire (FFQ) and dietary patterns were derived through Latent 
      Class Analysis (LCA). Then, Logistics regression analyses were used to evaluate 
      the associations of FPG, HbA1c with different dietary patterns. The BMI 
      (BMI = height/weight(2)) was used as a moderator to estimate the mediating 
      effect. Mediation analysis was performed using hypothetical variables, the 
      mediation variables, to identify and explain the observed mechanism of 
      association between the independent and dependent variables while the moderation 
      effect was tested with multiple regression analysis with interaction terms. 
      RESULTS: After completing Latent Class Analysis (LCA), the dietary patterns were 
      divided into three categories: TypeI, TypeII, TypeIII. After adjusting for 
      confounding factors such as gender, age, education level, marital status, family 
      income, smoking, drinking, disease course, HDL-C, LDL-C, TC, TG, oral 
      hypoglycemic drugs, insulin therapy, Hypertension, Coronary heart disease, 
      Stroke, Type III were all significantly associated with HbA1c compared to those 
      with Type I (P < 0.05), and the research showed the patients with Type III had 
      High glycemic control rate. Taking type I as the reference level, the 95% 
      Bootstrap confidence intervals of the relative mediating effect of TypeIII on FPG 
      were (-0.039, -0.005), except 0, indicating that the relative mediating effect 
      was significant (alpha(III) = 0.346*, beta(IIIFPG) = -0.060*). The mediating effect 
      analysis was performed to demonstrate that BMI was used as a moderator to 
      estimate the moderation effect. CONCLUSIONS: Our findings demonstrate that 
      consuming Type III dietary patterns associates with good glycemic control in T2DM 
      and the BMI associations would be playing a two-way effect between diet and FPG 
      in Chinese population with T2DM, indicated that Type III could not only directly 
      affect FPG, but also affect FPG through the mediating effect of BMI.
CI  - (c) 2023. The Author(s).
FAU - Saiyi Wang
AU  - Saiyi Wang
AD  - Huai 'an Center for Disease Control and Prevention, Huaian, 223001, China.
AD  - School of public health, Xuzhou Medical University, Xuzhou, 221004, China.
FAU - Wen, Jinbo
AU  - Wen J
AD  - Huai 'an Center for Disease Control and Prevention, Huaian, 223001, China.
FAU - Miao, Dandan
AU  - Miao D
AD  - Huai 'an Center for Disease Control and Prevention, Huaian, 223001, China.
FAU - Sun, Zhongming
AU  - Sun Z
AD  - Huai 'an Center for Disease Control and Prevention, Huaian, 223001, China.
FAU - Li, Dianjiang
AU  - Li D
AD  - Department of Social Medicine and Health Education, School of Public Health, 
      Nanjing Medical University, Nanjing, 211166, China.
FAU - Pan, Enchun
AU  - Pan E
AD  - Huai 'an Center for Disease Control and Prevention, Huaian, 223001, China. 
      hypec@163.com.
AD  - School of public health, Xuzhou Medical University, Xuzhou, 221004, China. 
      hypec@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230310
PL  - England
TA  - BMC Public Health
JT  - BMC public health
JID - 100968562
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - *Diabetes Mellitus, Type 2
MH  - Glycated Hemoglobin
MH  - Blood Glucose/analysis
MH  - Cross-Sectional Studies
MH  - Body Mass Index
MH  - Glycemic Control
MH  - China/epidemiology
PMC - PMC10007773
OTO - NOTNLM
OT  - Dietary pattern
OT  - Fasting Plasma Glucose
OT  - Glycosylated hemoglobin
OT  - Mediating effect
OT  - T2DM
COIS- The authors declared no conflict of interest.
EDAT- 2023/03/11 06:00
MHDA- 2023/03/15 06:00
PMCR- 2023/03/10
CRDT- 2023/03/10 23:35
PHST- 2022/07/26 00:00 [received]
PHST- 2022/12/12 00:00 [accepted]
PHST- 2023/03/10 23:35 [entrez]
PHST- 2023/03/11 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/03/10 00:00 [pmc-release]
AID - 10.1186/s12889-022-14856-5 [pii]
AID - 14856 [pii]
AID - 10.1186/s12889-022-14856-5 [doi]
PST - epublish
SO  - BMC Public Health. 2023 Mar 10;23(1):468. doi: 10.1186/s12889-022-14856-5.