PMID- 36899670
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230313
IS  - 2076-2615 (Print)
IS  - 2076-2615 (Electronic)
IS  - 2076-2615 (Linking)
VI  - 13
IP  - 5
DP  - 2023 Feb 23
TI  - Research Progress on Glycoprotein 5 of Porcine Reproductive and Respiratory 
      Syndrome Virus.
LID - 10.3390/ani13050813 [doi]
LID - 813
AB  - Porcine reproductive and respiratory syndrome (PRRS) is an acute, febrile, and 
      highly contagious disease caused by the porcine reproductive and respiratory 
      syndrome virus (PRRSV). Glycoprotein 5 (GP5) is a glycosylated envelope protein 
      encoded by the PRRSV ORF5, which has good immunogenicity and can induce the body 
      to produce neutralizing antibodies. Therefore, study of GP5 protein is of great 
      significance in the diagnosis, prevention, and control of PRRSV and the 
      development of new vaccines. We reviewed GP5 protein genetic variation, immune 
      function, interaction with viral protein and host proteins, induction of cell 
      apoptosis, and stimulation of neutralizing antibodies. GP5 protein's influence on 
      virus replication and virulence, as well as its use as a target for viral 
      detection and immunization are reviewed.
FAU - Luo, Qin
AU  - Luo Q
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
FAU - Zheng, Yajie
AU  - Zheng Y
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
FAU - Zhang, Hang
AU  - Zhang H
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
FAU - Yang, Zhiyu
AU  - Yang Z
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
FAU - Sha, Huiyang
AU  - Sha H
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
FAU - Kong, Weili
AU  - Kong W
AUID- ORCID: 0000-0002-9104-7730
AD  - Gladstone Institutes of Virology and Immunology, University of California, San 
      Francisco, CA 94158, USA.
FAU - Zhao, Mengmeng
AU  - Zhao M
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
FAU - Wang, Nina
AU  - Wang N
AD  - School of Life Science and Engineering, Foshan University, Foshan 528231, China.
LA  - eng
GR  - 31902279/National Natural Science Foundation of China/
GR  - 31902284/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Review
DEP - 20230223
PL  - Switzerland
TA  - Animals (Basel)
JT  - Animals : an open access journal from MDPI
JID - 101635614
PMC - PMC10000246
OTO - NOTNLM
OT  - GP5 protein
OT  - host proteins
OT  - porcine reproductive and respiratory syndrome virus
OT  - vaccines
COIS- The authors declare that they have no competing interests.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/12 06:01
PMCR- 2023/02/23
CRDT- 2023/03/11 01:02
PHST- 2022/12/07 00:00 [received]
PHST- 2023/02/14 00:00 [revised]
PHST- 2023/02/20 00:00 [accepted]
PHST- 2023/03/11 01:02 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/12 06:01 [medline]
PHST- 2023/02/23 00:00 [pmc-release]
AID - ani13050813 [pii]
AID - animals-13-00813 [pii]
AID - 10.3390/ani13050813 [doi]
PST - epublish
SO  - Animals (Basel). 2023 Feb 23;13(5):813. doi: 10.3390/ani13050813.