PMID- 36900329
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230313
IS  - 2072-6694 (Print)
IS  - 2072-6694 (Electronic)
IS  - 2072-6694 (Linking)
VI  - 15
IP  - 5
DP  - 2023 Feb 28
TI  - Association between Iron Deficiency and Survival in Older Patients with Cancer.
LID - 10.3390/cancers15051533 [doi]
LID - 1533
AB  - BACKGROUND: iron deficiency (ID) is frequent in older patients. PURPOSE: to 
      evaluate the association between ID and survival in patients >/= 75 years old with 
      confirmed solid tumors. METHODS: a retrospective monocentric study including 
      patients between 2009 and 2018. ID, absolute ID (AID) and functional ID (FID) 
      were defined according to the European Society for Medical Oncology (ESMO) 
      criteria. Severe ID was defined by a ferritin level < 30 microg/L. RESULTS: in total, 
      556 patients were included, the mean age was 82 (+/-4.6) years, 56% were male, the 
      most frequent cancer was colon cancer (19%, n = 104), and metastatic cancers were 
      found in 38% (n = 211). Median follow-up time: 484 [190-1377] days. In anemic 
      patients, ID and FID were independently associated with an increased risk of 
      mortality (respectively, HR 1.51; p = 0.0065 and HR 1.73; p = 0.0007). In 
      non-anemic patients, FID was independently associated with better survival (HR 
      0.65; p = 0.0495). CONCLUSION: in our study, ID was significantly associated with 
      survival, and with better survival for patients without anemia. These results 
      suggest that attention should be paid to the iron status in older patients with 
      tumors and raise questions about the prognostic value of iron supplementation for 
      iron-deficient patients without anemia.
FAU - Tisserand, Julie
AU  - Tisserand J
AUID- ORCID: 0009-0000-9039-3829
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Randrian, Violaine
AU  - Randrian V
AUID- ORCID: 0000-0002-0155-1766
AD  - ProDiCeT, CHU Poitiers, Universite de Poitiers, 86000 Poitiers, France.
AD  - Gastroenterology and Hepatology Department, Poitiers University Hospital, 86000 
      Poitiers, France.
FAU - Paccalin, Marc
AU  - Paccalin M
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
AD  - University Hospital Poitiers, University of Poitiers, INSERM CIC 1402, 2 rue de 
      la Miletrie, CEDEX, 86021 Poitiers, France.
FAU - Saulnier, Pierre-Jean
AU  - Saulnier PJ
AD  - University Hospital Poitiers, University of Poitiers, INSERM CIC 1402, 2 rue de 
      la Miletrie, CEDEX, 86021 Poitiers, France.
FAU - Arviset, Marine
AU  - Arviset M
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Fourmy, Arthur
AU  - Fourmy A
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Arriudarre, Victor
AU  - Arriudarre V
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Jamet, Amelie
AU  - Jamet A
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Moreno, Yvan
AU  - Moreno Y
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Valero, Simon
AU  - Valero S
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
FAU - Liuu, Evelyne
AU  - Liuu E
AUID- ORCID: 0000-0003-2758-5064
AD  - Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France.
AD  - University Hospital Poitiers, University of Poitiers, INSERM CIC 1402, 2 rue de 
      la Miletrie, CEDEX, 86021 Poitiers, France.
LA  - eng
PT  - Journal Article
DEP - 20230228
PL  - Switzerland
TA  - Cancers (Basel)
JT  - Cancers
JID - 101526829
PMC - PMC10000607
OTO - NOTNLM
OT  - geriatric medicine
OT  - geriatric oncology
OT  - iron deficiency
OT  - mortality
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/12 06:01
PMCR- 2023/02/28
CRDT- 2023/03/11 01:06
PHST- 2023/01/15 00:00 [received]
PHST- 2023/02/22 00:00 [revised]
PHST- 2023/02/26 00:00 [accepted]
PHST- 2023/03/11 01:06 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/12 06:01 [medline]
PHST- 2023/02/28 00:00 [pmc-release]
AID - cancers15051533 [pii]
AID - cancers-15-01533 [pii]
AID - 10.3390/cancers15051533 [doi]
PST - epublish
SO  - Cancers (Basel). 2023 Feb 28;15(5):1533. doi: 10.3390/cancers15051533.