PMID- 36900595
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230313
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 12
IP  - 5
DP  - 2023 Mar 3
TI  - Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on 
      Ethanol-Induced Damage to HepG2 Cells and Animal Models.
LID - 10.3390/foods12051078 [doi]
LID - 1078
AB  - Alcohol liver disease (ALD) is one of the leading outcomes of acute and chronic 
      liver injury. Accumulative evidence has confirmed that oxidative stress is 
      involved in the development of ALD. In this study, we used chick embryos to 
      establish ALD model to study the hepatoprotective effects of tamarind shell 
      exttract (TSE). Chick embryos received 25% ethanol (75 muL) and TSE (250, 500, 750 
      mug/egg/75 muL) from embryonic development day (EDD) 5.5. Both ethanol and TSE were 
      administrated every two days until EDD15. Ethanol-exposed zebrafish and HepG2 
      cell model were also employed. The results suggested that TSE effectively 
      reversed the pathological changes, liver dysfunction and ethanol-metabolic enzyme 
      disorder in ethanol-treated chick embryo liver, zebrafish and HepG2 cells. TSE 
      suppressed the excessive reactive oxygen species (ROS) in zebrafish and HepG2 
      cells, as well as rebuilt the irrupted mitochondrial membrane potential. 
      Meanwhile, the declined antioxidative activity of glutathione peroxidase (GPx) 
      and superoxide dismutase (SOD), together with the content of total glutathione 
      (T-GSH) were recovered by TSE. Moreover, TSE upregulated nuclear factor erythroid 
      2-related factor 2 (NRF2) and heme oxyense-1 (HO-1) expression in protein and 
      mRNA level. All the phenomena suggested that TSE attenuated ALD through 
      activating NRF2 to repress the oxidative stress induced by ethanol.
FAU - Han, Shao-Cong
AU  - Han SC
AD  - College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, 
      Kunming 650500, China.
FAU - Huang, Rong-Ping
AU  - Huang RP
AD  - College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, 
      Kunming 650500, China.
FAU - Zhang, Qiong-Yi
AU  - Zhang QY
AD  - Guangdong Engineering Research Centre of Chinese Medicine & Disease 
      Susceptibility, Jinan University, Guangzhou 510632, China.
FAU - Yan, Chang-Yu
AU  - Yan CY
AD  - Guangdong Engineering Research Centre of Chinese Medicine & Disease 
      Susceptibility, Jinan University, Guangzhou 510632, China.
FAU - Li, Xi-You
AU  - Li XY
AD  - College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, 
      Kunming 650500, China.
FAU - Li, Yi-Fang
AU  - Li YF
AD  - Guangdong Engineering Research Centre of Chinese Medicine & Disease 
      Susceptibility, Jinan University, Guangzhou 510632, China.
FAU - He, Rong-Rong
AU  - He RR
AUID- ORCID: 0000-0001-5505-5672
AD  - Guangdong Engineering Research Centre of Chinese Medicine & Disease 
      Susceptibility, Jinan University, Guangzhou 510632, China.
FAU - Li, Wei-Xi
AU  - Li WX
AUID- ORCID: 0000-0002-1702-8435
AD  - College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, 
      Kunming 650500, China.
LA  - eng
GR  - 81960780/National Natural Science Foundation of China/
GR  - U1801284/National Natural Science Foundation of China/
GR  - (2019FF002 (-007), 2017FF116 (-015))/Yunnan Provincial Science and Technology 
      Department-Applied Basic Research Joint Special Funds of Yunnan University of 
      Chinese Medicine/
PT  - Journal Article
DEP - 20230303
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC10000874
OTO - NOTNLM
OT  - NRF2
OT  - alcohol liver disease
OT  - chick embryo
OT  - oxidative stress
OT  - tamarind shell extract
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/12 06:01
PMCR- 2023/03/03
CRDT- 2023/03/11 01:07
PHST- 2023/02/14 00:00 [received]
PHST- 2023/02/28 00:00 [revised]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/03/11 01:07 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/12 06:01 [medline]
PHST- 2023/03/03 00:00 [pmc-release]
AID - foods12051078 [pii]
AID - foods-12-01078 [pii]
AID - 10.3390/foods12051078 [doi]
PST - epublish
SO  - Foods. 2023 Mar 3;12(5):1078. doi: 10.3390/foods12051078.