PMID- 36902019
OWN - NLM
STAT- MEDLINE
DCOM- 20230314
LR  - 20230314
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 24
IP  - 5
DP  - 2023 Feb 27
TI  - Long-Term Results of Adjunct Autologous Platelet-Rich Plasma in Lamellar Macular 
      Hole Surgery Showing Lasting Restoration of Foveal Anatomy.
LID - 10.3390/ijms24054589 [doi]
LID - 4589
AB  - The aim of this study was to evaluate the long-time results of highly 
      concentrated autologous platelet-rich plasma (PRP) used as an adjunct in lamellar 
      macular hole (LMH) surgery. Nineteen eyes of nineteen patients with progressive 
      LMH were enrolled in this interventional case series, on which 23/25-gauge pars 
      plana vitrectomy was performed and 0.1 mL of highly concentrated autologous 
      platelet-rich plasma was applied under air tamponade. Posterior vitreous 
      detachment was induced, and the peeling of tractive epiretinal membranes, 
      whenever present, was performed. In cases of phakic lens status, combined surgery 
      was carried out. Postoperatively, all patients were instructed to remain in a 
      supine position for the first two postoperative hours. Best-corrected visual 
      acuity (BCVA) testing, microperimetry, and spectral domain optical coherence 
      tomography (SD-OCT) were carried out preoperatively and at minimum 6 months (in 
      median 12 months) postoperatively. Foveal configuration was postoperatively 
      restored in 19 of 19 patients. Two patients who had not undergone ILM peeling 
      showed a recurring defect at 6-month follow-up. Best-corrected visual acuity 
      improved significantly from 0.29 +/- 0.08 to 0.14 +/- 0.13 logMAR (p = 0.028, 
      Wilcoxon signed-rank test). Microperimetry remained unchanged (23.38 +/- 2.53 
      preoperatively; 23.0 +/- 2.49 dB postoperatively; p = 0.67). No patients 
      experienced vision loss after surgery, and no significant intra- or postoperative 
      complications were observed. Using PRP as an adjunct in macular hole surgery 
      significantly improves morphological and functional outcomes. Additionally, it 
      might be an effective prophylaxis to further progression and also the formation 
      of a secondary full-thickness macular hole. The results of this study might 
      contribute to a paradigm shift in macular hole surgery towards early 
      intervention.
FAU - Hagenau, Felix
AU  - Hagenau F
AUID- ORCID: 0000-0002-1322-0649
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
AD  - Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, 20251 
      Hamburg, Germany.
FAU - Osterode, Elisa V
AU  - Osterode EV
AUID- ORCID: 0000-0003-4359-2096
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Klaas, Julian E
AU  - Klaas JE
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Vogt, Denise
AU  - Vogt D
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Keidel, Leonie F
AU  - Keidel LF
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Schworm, Benedikt
AU  - Schworm B
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Siedlecki, Jakob
AU  - Siedlecki J
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Mayer, Wolfgang J
AU  - Mayer WJ
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Kreutzer, Thomas C
AU  - Kreutzer TC
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
FAU - Priglinger, Siegfried G
AU  - Priglinger SG
AUID- ORCID: 0000-0002-5580-612X
AD  - Department of Ophthalmology, University Hospital, LMU Munich, 80336 Munich, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20230227
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Humans
MH  - *Retinal Perforations/complications/surgery
MH  - Neoplasm Recurrence, Local/surgery
MH  - Fovea Centralis
MH  - *Epiretinal Membrane/complications/surgery
MH  - Vitrectomy/methods
MH  - Tomography, Optical Coherence/methods
MH  - Retrospective Studies
PMC - PMC10002568
OTO - NOTNLM
OT  - LMH
OT  - Mueller cells
OT  - PRP
OT  - lamellar macular hole
OT  - peeling
OT  - platelet-rich plasma
OT  - retina
OT  - vitrectomy
COIS- The authors declare no competing interest.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/15 06:00
PMCR- 2023/02/27
CRDT- 2023/03/11 01:17
PHST- 2022/12/03 00:00 [received]
PHST- 2023/01/18 00:00 [revised]
PHST- 2023/02/23 00:00 [accepted]
PHST- 2023/03/11 01:17 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
PHST- 2023/02/27 00:00 [pmc-release]
AID - ijms24054589 [pii]
AID - ijms-24-04589 [pii]
AID - 10.3390/ijms24054589 [doi]
PST - epublish
SO  - Int J Mol Sci. 2023 Feb 27;24(5):4589. doi: 10.3390/ijms24054589.