PMID- 36902133 OWN - NLM STAT- MEDLINE DCOM- 20230314 LR - 20230314 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 24 IP - 5 DP - 2023 Feb 28 TI - Chronic Exposure to High Fat Diet Affects the Synaptic Transmission That Regulates the Dopamine Release in the Nucleus Accumbens of Adolescent Male Rats. LID - 10.3390/ijms24054703 [doi] LID - 4703 AB - Obesity is a pandemic caused by many factors, including a chronic excess in hypercaloric and high-palatable food intake. In addition, the global prevalence of obesity has increased in all age categories, such as children, adolescents, and adults. However, at the neurobiological level, how neural circuits regulate the hedonic consumption of food intake and how the reward circuit is modified under hypercaloric diet consumption are still being unraveled. We aimed to determine the molecular and functional changes of dopaminergic and glutamatergic modulation of nucleus accumbens (NAcc) in male rats exposed to chronic consumption of a high-fat diet (HFD). Male Sprague-Dawley rats were fed a chow diet or HFD from postnatal day (PND) 21 to 62, increasing obesity markers. In addition, in HFD rats, the frequency but not amplitude of the spontaneous excitatory postsynaptic current is increased in NAcc medium spiny neurons (MSNs). Moreover, only MSNs expressing dopamine (DA) receptor type 2 (D(2)) increase the amplitude and glutamate release in response to amphetamine, downregulating the indirect pathway. Furthermore, NAcc gene expression of inflammasome components is increased by chronic exposure to HFD. At the neurochemical level, DOPAC content and tonic dopamine (DA) release are reduced in NAcc, while phasic DA release is increased in HFD-fed rats. In conclusion, our model of childhood and adolescent obesity functionally affects the NAcc, a brain nucleus involved in the hedonic control of feeding, which might trigger addictive-like behaviors for obesogenic foods and, through positive feedback, maintain the obese phenotype. FAU - Plaza-Briceno, Wladimir AU - Plaza-Briceno W AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. AD - Programa de Doctorado en Ciencias Mencion Neurociencias, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Velasquez, Victoria B AU - Velasquez VB AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. AD - Programa de Doctorado en Ciencias Mencion Neurociencias, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Silva-Olivares, Francisco AU - Silva-Olivares F AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. AD - Programa de Doctorado en Ciencias Mencion Neurociencias, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. AD - Instituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomia, Universidad de las Americas, Vina del Mar 2520000, Chile. FAU - Ceballo, Karina AU - Ceballo K AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. AD - Programa de Doctorado en Ciencias Mencion Neurociencias, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Cespedes, Ricardo AU - Cespedes R AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. AD - Programa de Doctorado en Ciencias Mencion Neurociencias, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Jorquera, Gonzalo AU - Jorquera G AUID- ORCID: 0000-0001-7890-7321 AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Cruz, Gonzalo AU - Cruz G AUID- ORCID: 0000-0002-1458-3599 AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Martinez-Pinto, Jonathan AU - Martinez-Pinto J AUID- ORCID: 0000-0001-8628-892X AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Bonansco, Christian AU - Bonansco C AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. FAU - Sotomayor-Zarate, Ramon AU - Sotomayor-Zarate R AUID- ORCID: 0000-0002-1239-5367 AD - Centro de Neurobiologia y Fisiopatologia Integrativa (CENFI), Instituto de Fisiologia, Facultad de Ciencias, Universidad de Valparaiso, Valparaiso 2360102, Chile. LA - eng GR - 120-0474/FONDECYT/ GR - 120-1816/FONDECYT/ GR - 01/2006/DIUV-CI/ PT - Journal Article DEP - 20230228 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - VTD58H1Z2X (Dopamine) RN - 0 (Receptors, Dopamine) SB - IM MH - Rats MH - Male MH - Animals MH - *Dopamine/metabolism MH - Nucleus Accumbens/metabolism MH - Diet, High-Fat MH - Rats, Sprague-Dawley MH - *Pediatric Obesity/metabolism MH - Synaptic Transmission/physiology MH - Receptors, Dopamine/metabolism PMC - PMC10003643 OTO - NOTNLM OT - FSCV OT - HFD OT - accumbens OT - dopamine OT - electrophysiology OT - neuroinflammation COIS- The authors declare no conflict of interest. EDAT- 2023/03/12 06:00 MHDA- 2023/03/15 06:00 PMCR- 2023/02/28 CRDT- 2023/03/11 01:17 PHST- 2022/10/13 00:00 [received] PHST- 2022/12/21 00:00 [revised] PHST- 2022/12/23 00:00 [accepted] PHST- 2023/03/11 01:17 [entrez] PHST- 2023/03/12 06:00 [pubmed] PHST- 2023/03/15 06:00 [medline] PHST- 2023/02/28 00:00 [pmc-release] AID - ijms24054703 [pii] AID - ijms-24-04703 [pii] AID - 10.3390/ijms24054703 [doi] PST - epublish SO - Int J Mol Sci. 2023 Feb 28;24(5):4703. doi: 10.3390/ijms24054703.