PMID- 36904474
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 15
IP  - 5
DP  - 2023 Feb 28
TI  - Recent Advances in the Application of ATRP in the Synthesis of Drug Delivery 
      Systems.
LID - 10.3390/polym15051234 [doi]
LID - 1234
AB  - Advances in atom transfer radical polymerization (ATRP) have enabled the precise 
      design and preparation of nanostructured polymeric materials for a variety of 
      biomedical applications. This paper briefly summarizes recent developments in the 
      synthesis of bio-therapeutics for drug delivery based on linear and branched 
      block copolymers and bioconjugates using ATRP, which have been tested in drug 
      delivery systems (DDSs) over the past decade. An important trend is the rapid 
      development of a number of smart DDSs that can release bioactive materials in 
      response to certain external stimuli, either physical (e.g., light, ultrasound, 
      or temperature) or chemical factors (e.g., changes in pH values and/or 
      environmental redox potential). The use of ATRPs in the synthesis of polymeric 
      bioconjugates containing drugs, proteins, and nucleic acids, as well as systems 
      applied in combination therapies, has also received considerable attention.
FAU - Szewczyk-Lagodzinska, Matylda
AU  - Szewczyk-Lagodzinska M
AUID- ORCID: 0000-0002-9613-7962
AD  - Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 
      Warsaw, Poland.
FAU - Plichta, Andrzej
AU  - Plichta A
AUID- ORCID: 0000-0002-4935-2627
AD  - Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 
      Warsaw, Poland.
FAU - Debowski, Maciej
AU  - Debowski M
AUID- ORCID: 0000-0001-5405-8433
AD  - Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 
      Warsaw, Poland.
FAU - Kowalczyk, Sebastian
AU  - Kowalczyk S
AUID- ORCID: 0000-0002-9372-3122
AD  - Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 
      Warsaw, Poland.
FAU - Iuliano, Anna
AU  - Iuliano A
AUID- ORCID: 0000-0001-8429-3354
AD  - Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 
      Warsaw, Poland.
FAU - Florjanczyk, Zbigniew
AU  - Florjanczyk Z
AUID- ORCID: 0000-0002-0619-944X
AD  - Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 
      Warsaw, Poland.
LA  - eng
GR  - 504/04109/1020/44.000000/Warsaw University of Technology/
PT  - Journal Article
PT  - Review
DEP - 20230228
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC10007417
OTO - NOTNLM
OT  - ATRP
OT  - block copolymer
OT  - branched copolymer
OT  - drug delivery system
OT  - drug nanocarrier
OT  - micelle
OT  - polymersome
OT  - polymer-drug conjugate
OT  - polyplexes
OT  - self-assembly
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/12 06:01
PMCR- 2023/02/28
CRDT- 2023/03/11 01:31
PHST- 2023/02/06 00:00 [received]
PHST- 2023/02/26 00:00 [revised]
PHST- 2023/02/27 00:00 [accepted]
PHST- 2023/03/11 01:31 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/12 06:01 [medline]
PHST- 2023/02/28 00:00 [pmc-release]
AID - polym15051234 [pii]
AID - polymers-15-01234 [pii]
AID - 10.3390/polym15051234 [doi]
PST - epublish
SO  - Polymers (Basel). 2023 Feb 28;15(5):1234. doi: 10.3390/polym15051234.