PMID- 36904500
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 15
IP  - 5
DP  - 2023 Mar 1
TI  - Imidazolium Salts for Candida spp. Antibiofilm High-Density Polyethylene-Based 
      Biomaterials.
LID - 10.3390/polym15051259 [doi]
LID - 1259
AB  - The species of Candida present good capability to form fungal biofilms on 
      polymeric surfaces and are related to several human diseases since many of the 
      employed medical devices are designed using polymers, especially high-density 
      polyethylene (HDPE). Herein, HDPE films containing 0; 0.125; 0.250 or 0.500 wt% 
      of 1-hexadecyl-3-methylimidazolium chloride (C(16)MImCl) or its analog 
      1-hexadecyl-3-methylimidazolium methanesulfonate (C(16)MImMeS) were obtained by 
      melt blending and posteriorly mechanically pressurized into films. This approach 
      resulted in more flexible and less brittle films, which impeded the Candida 
      albicans, C. parapsilosis, and C. tropicalis biofilm formation on their surfaces. 
      The employed imidazolium salt (IS) concentrations did not present any significant 
      cytotoxic effect, and the good cell adhesion/proliferation of human mesenchymal 
      stem cells on the HDPE-IS films indicated good biocompatibility. These outcomes 
      combined with the absence of microscopic lesions in pig skin after contact with 
      HDPE-IS films demonstrated their potential as biomaterials for the development of 
      effective medical device tools that reduce the risk of fungal infections.
FAU - Martins Leal Schrekker, Clarissa
AU  - Martins Leal Schrekker C
AD  - Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul 
      (UFRGS), Rua Sarmento Leite 500, Porto Alegre 90050-170, RS, Brazil.
FAU - Sokolovicz, Yuri Clemente Andrade
AU  - Sokolovicz YCA
AUID- ORCID: 0000-0002-5956-2433
AD  - Laboratory of Technological Processes and Catalysis, Institute of Chemistry, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Goncalves 9500, 
      Porto Alegre 91501-970, RS, Brazil.
FAU - Raucci, Maria Grazia
AU  - Raucci MG
AUID- ORCID: 0000-0002-0516-4181
AD  - Institute of Polymers, Composites and Biomaterials, National Research Council of 
      Italy (IPCB-CNR), Viale John Fitzgerald Kennedy 54, Mostra d'Oltremare Padiglione 
      20, 80125 Naples, Italy.
FAU - Leal, Claudio Alberto Martins
AU  - Leal CAM
AD  - Laboratory of Technological Processes and Catalysis, Institute of Chemistry, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Goncalves 9500, 
      Porto Alegre 91501-970, RS, Brazil.
FAU - Ambrosio, Luigi
AU  - Ambrosio L
AD  - Institute of Polymers, Composites and Biomaterials, National Research Council of 
      Italy (IPCB-CNR), Viale John Fitzgerald Kennedy 54, Mostra d'Oltremare Padiglione 
      20, 80125 Naples, Italy.
FAU - Lettieri Teixeira, Mario
AU  - Lettieri Teixeira M
AUID- ORCID: 0000-0003-4546-5584
AD  - Laboratory of Biochemistry and Toxicology, Instituto Federal Catarinense (IFC), 
      Rodovia SC 283-km 17, Concordia 89703-720, SC, Brazil.
FAU - Meneghello Fuentefria, Alexandre
AU  - Meneghello Fuentefria A
AUID- ORCID: 0000-0003-2979-4417
AD  - Institute of Basic Health Sciences, Universidade Federal do Rio Grande do Sul 
      (UFRGS), Rua Sarmento Leite 500, Porto Alegre 90050-170, RS, Brazil.
AD  - Faculty of Pharmacy, Universidade Federal do Rio Grande do Sul (UFRGS), Avenida 
      Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil.
FAU - Schrekker, Henri Stephan
AU  - Schrekker HS
AUID- ORCID: 0000-0002-8173-3841
AD  - Laboratory of Technological Processes and Catalysis, Institute of Chemistry, 
      Universidade Federal do Rio Grande do Sul (UFRGS), Avenida Bento Goncalves 9500, 
      Porto Alegre 91501-970, RS, Brazil.
LA  - eng
GR  - Finance Code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/
GR  - 400531/2013-5/National Council for Scientific and Technological Development/
PT  - Journal Article
DEP - 20230301
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC10007465
OTO - NOTNLM
OT  - biocompatibility
OT  - histopathological evaluation
OT  - human mesenchymal stem cells
OT  - ionic liquid
OT  - melt blending
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/12 06:01
PMCR- 2023/03/01
CRDT- 2023/03/11 01:32
PHST- 2022/10/24 00:00 [received]
PHST- 2023/02/07 00:00 [revised]
PHST- 2023/02/14 00:00 [accepted]
PHST- 2023/03/11 01:32 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/12 06:01 [medline]
PHST- 2023/03/01 00:00 [pmc-release]
AID - polym15051259 [pii]
AID - polymers-15-01259 [pii]
AID - 10.3390/polym15051259 [doi]
PST - epublish
SO  - Polymers (Basel). 2023 Mar 1;15(5):1259. doi: 10.3390/polym15051259.