PMID- 36904532
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 15
IP  - 5
DP  - 2023 Mar 3
TI  - Investigation on Centrifugally Spun Fibrous PCL/3-Methyl Mannoside Mats for Wound 
      Healing Application.
LID - 10.3390/polym15051293 [doi]
LID - 1293
AB  - Fibrous structures, in general, have splendid advantages in different forms of 
      micro- and nanomembranes in various fields, including tissue engineering, 
      filtration, clothing, energy storage, etc. In the present work, we develop a 
      fibrous mat by blending the bioactive extract of Cassia auriculata (CA) with 
      polycaprolactone (PCL) using the centrifugal spinning (c-spinning) technique for 
      tissue-engineered implantable material and wound dressing applications. The 
      fibrous mats were developed at a centrifugal speed of 3500 rpm. The PCL 
      concentration for centrifugal spinning with CA extract was optimized at 15% w/v 
      of PCL to achieve better fiber formation. Increasing the extract concentration by 
      more than 2% resulted in crimping of fibers with irregular morphology. The 
      development of fibrous mats using a dual solvent combination resulted in fine 
      pores on the fiber structure. Scanning electron microscope (SEM) images showed 
      that the surface morphology of the fibers in the produced fiber mats (PCL and 
      PCL-CA) was highly porous. Gas chromatography-mass spectrometry (GC-MS) analysis 
      revealed that the CA extract contained 3-methyl mannoside as the predominant 
      component. The in vitro cell line studies using NIH3T3 fibroblasts demonstrated 
      that the CA-PCL nanofiber mat was highly biocompatible, supporting cell 
      proliferation. Hence, we conclude that the c-spun, CA-incorporating nanofiber mat 
      can be employed as a tissue-engineered construct for wound healing applications.
FAU - Mary, Soloman Agnes
AU  - Mary SA
AD  - Centre for Academic and Research Excellence, CSIR-Central Leather Research 
      Institute Adyar, Chennai 600020, India.
FAU - Ariram, Naisini
AU  - Ariram N
AD  - Centre for Academic and Research Excellence, CSIR-Central Leather Research 
      Institute Adyar, Chennai 600020, India.
FAU - Gopinath, Arun
AU  - Gopinath A
AD  - Centre for Academic and Research Excellence, CSIR-Central Leather Research 
      Institute Adyar, Chennai 600020, India.
FAU - Chinnaiyan, Senthil Kumar
AU  - Chinnaiyan SK
AD  - Centre for Academic and Research Excellence, CSIR-Central Leather Research 
      Institute Adyar, Chennai 600020, India.
FAU - Raja, Iruthayapandi Selestin
AU  - Raja IS
AUID- ORCID: 0000-0002-2952-5551
AD  - BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, 
      Republic of Korea.
FAU - Sahu, Bindia
AU  - Sahu B
AD  - Centre for Academic and Research Excellence, CSIR-Central Leather Research 
      Institute Adyar, Chennai 600020, India.
FAU - Giri Dev, Venkateshwarapuram Rengaswami
AU  - Giri Dev VR
AD  - Department of Textile Technology, Anna University, Chennai 600025, India.
FAU - Han, Dong-Wook
AU  - Han DW
AUID- ORCID: 0000-0001-8314-1981
AD  - BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, 
      Republic of Korea.
AD  - Department of Cogno-Mechatronics Engineering, College of Nanoscience & 
      Nanotechnology, Pusan National University, Busan 46241, Republic of Korea.
FAU - Madhan, Balaraman
AU  - Madhan B
AD  - Centre for Academic and Research Excellence, CSIR-Central Leather Research 
      Institute Adyar, Chennai 600020, India.
LA  - eng
GR  - NPDF, PDF/2016/001770/Science and Engineering Research Board/
GR  - A/2020/CRE/GAP1614/1487/CLRI Communication/
GR  - 2022R1I1A1A01064416/National Research Foundation of Korea/
GR  - 2021003270006/Korea Environment Industry & Technology Institute/
PT  - Journal Article
DEP - 20230303
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC10007593
OTO - NOTNLM
OT  - cassia auriculata
OT  - centrifugal spinning
OT  - polycaprolactone
OT  - ultrafine porous fibers
OT  - wound healing
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/12 06:00
MHDA- 2023/03/12 06:01
PMCR- 2023/03/03
CRDT- 2023/03/11 01:32
PHST- 2023/01/26 00:00 [received]
PHST- 2023/02/16 00:00 [revised]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/03/11 01:32 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/12 06:01 [medline]
PHST- 2023/03/03 00:00 [pmc-release]
AID - polym15051293 [pii]
AID - polymers-15-01293 [pii]
AID - 10.3390/polym15051293 [doi]
PST - epublish
SO  - Polymers (Basel). 2023 Mar 3;15(5):1293. doi: 10.3390/polym15051293.