PMID- 36905079
OWN - NLM
STAT- MEDLINE
DCOM- 20230719
LR  - 20230719
IS  - 1472-8206 (Electronic)
IS  - 0767-3981 (Linking)
VI  - 37
IP  - 4
DP  - 2023 Aug
TI  - Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin 
      resistance with type 2 diabetes mellitus.
PG  - 769-778
LID - 10.1111/fcp.12892 [doi]
AB  - Streptozotocin (STZ) is a broad-spectrum antibiotic that is toxic to the 
      insulin-producing beta cells of the pancreatic islets. STZ is currently used 
      clinically for the treatment of metastatic islet cell carcinoma of the pancreas 
      and the induction of diabetes mellitus (DM) in rodents. So far, there has been no 
      previous research to show that STZ injection in rodents causes insulin resistance 
      in type 2 diabetes mellitus (T2DM). The purpose of this study was to determine if 
      rats (Sprague-Dawley) developed type 2 diabetes mellitus (insulin resistance) 
      after 72 h of intraperitoneal administration of 50 mg/kg STZ. Rats with fasting 
      blood glucose levels above 11.0 mM, 72 h post-STZ induction, were used. The body 
      weight and plasma glucose levels were measured every week throughout the 60-day 
      treatment period. The plasma, liver, kidney, pancreas, and smooth muscle cells 
      were harvested for antioxidant, biochemical analysis, histology, and gene 
      expression studies. The results revealed that STZ was able to destroy the 
      pancreatic insulin-producing beta cell, as evidenced by an increase in plasma 
      glucose level, insulin resistance, and oxidative stress. Biochemical 
      investigation indicates that STZ can generate diabetes complications through 
      hepatocellular damage, elevated HbA1c, kidney damage, hyperlipidemia, 
      cardiovascular damage, and impairment of the insulin-signaling pathway.
CI  - (c) 2023 Societe Francaise de Pharmacologie et de Therapeutique. Published by John 
      Wiley & Sons Ltd.
FAU - Sharma, Mridula
AU  - Sharma M
AD  - Department of Biotechnology, Faculty of Applied Sciences, UCSI University, 
      Cheras, 56000, Kuala Lumpur, Malaysia.
FAU - Chan, Hor Kuan
AU  - Chan HK
AD  - Department of Food Sciences with Nutrition, Faculty of Applied Sciences, UCSI 
      University, Cheras, 56000, Kuala Lumpur, Malaysia.
FAU - Lavilla, Charlie A Jr
AU  - Lavilla CA Jr
AD  - Chemistry Department, College of Science and Mathematics, Mindanao State 
      University-Iligan Institute of Technology, Iligan City, Lanao del Norte, 9200, 
      Philippines.
FAU - Uy, Mylene M
AU  - Uy MM
AD  - Chemistry Department, College of Science and Mathematics, Mindanao State 
      University-Iligan Institute of Technology, Iligan City, Lanao del Norte, 9200, 
      Philippines.
FAU - Froemming, Gabriele Ruth Anisah
AU  - Froemming GRA
AD  - Department of Basic Medical Sciences, Faculty of Medicine and Health Sciences, 
      Universiti Malaysia Sarawak (UNIMAS), Kota Samarahan, Sarawak, 94300, Malaysia.
FAU - Okechukwu, Patrick Nwabueze
AU  - Okechukwu PN
AUID- ORCID: 0000-0002-3855-2666
AD  - Department of Biotechnology, Faculty of Applied Sciences, UCSI University, 
      Cheras, 56000, Kuala Lumpur, Malaysia.
LA  - eng
GR  - REIG-FAS-2020-031/UCSI University/
PT  - Journal Article
DEP - 20230317
PL  - England
TA  - Fundam Clin Pharmacol
JT  - Fundamental & clinical pharmacology
JID - 8710411
RN  - 5W494URQ81 (Streptozocin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Insulin Resistance
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Streptozocin
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - Rats, Sprague-Dawley
MH  - Insulin/metabolism
OTO - NOTNLM
OT  - IRS1-PI3K-AKT-GLUT4
OT  - diabetes mellitus
OT  - insulin resistance
OT  - insulin-signaling pathway
OT  - oxidative stress
OT  - streptozotocin
EDAT- 2023/03/12 06:00
MHDA- 2023/07/19 06:43
CRDT- 2023/03/11 01:35
PHST- 2023/02/18 00:00 [revised]
PHST- 2022/07/11 00:00 [received]
PHST- 2023/03/08 00:00 [accepted]
PHST- 2023/07/19 06:43 [medline]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/11 01:35 [entrez]
AID - 10.1111/fcp.12892 [doi]
PST - ppublish
SO  - Fundam Clin Pharmacol. 2023 Aug;37(4):769-778. doi: 10.1111/fcp.12892. Epub 2023 
      Mar 17.