PMID- 36905506
OWN - NLM
STAT- MEDLINE
DCOM- 20230322
LR  - 20230424
IS  - 1940-6029 (Electronic)
IS  - 1064-3745 (Linking)
VI  - 2618
DP  - 2023
TI  - Phenotypes and Functions of Human Dendritic Cell Subsets in the Tumor 
      Microenvironment.
PG  - 17-35
LID - 10.1007/978-1-0716-2938-3_2 [doi]
AB  - Dendritic cells (DCs) play a key role in the antitumor immunity, as they are at 
      the interface of innate and adaptive immunity. This important task can only be 
      performed thanks to the broad range of mechanisms that DCs can perform to 
      activate other immune cells. As DCs are well known for their outstanding capacity 
      to prime and activate T cells through antigen presentation, DCs were intensively 
      investigated during the past decades. Numerous studies have identified new DC 
      subsets, leading to a large variety of subsets commonly separated into cDC1, 
      cDC2, pDCs, mature DCs, Langerhans cells, monocyte-derived DCs, Axl-DCs, and 
      several other subsets. Here, we review the specific phenotypes, functions, and 
      localization within the tumor microenvironment (TME) of human DC subsets thanks 
      to flow cytometry and immunofluorescence but also with the help of high-output 
      technologies such as single-cell RNA sequencing and imaging mass cytometry (IMC).
CI  - (c) 2023. The Author(s), under exclusive license to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Sakref, Candice
AU  - Sakref C
AD  - Univ Lyon, Universite Claude Bernard Lyon 1, INSERM U1052, CNRS 5286, Centre de 
      Recherche en Cancerologie de Lyon, Lyon, France.
AD  - LabEx DEVweCAN, Lyon, France.
FAU - Bendriss-Vermare, Nathalie
AU  - Bendriss-Vermare N
AD  - Univ Lyon, Universite Claude Bernard Lyon 1, INSERM U1052, CNRS 5286, Centre de 
      Recherche en Cancerologie de Lyon, Lyon, France.
AD  - LabEx DEVweCAN, Lyon, France.
AD  - Laboratoire d'Immunotherapie des Cancers de Lyon (LICL), Lyon, France.
FAU - Valladeau-Guilemond, Jenny
AU  - Valladeau-Guilemond J
AD  - Univ Lyon, Universite Claude Bernard Lyon 1, INSERM U1052, CNRS 5286, Centre de 
      Recherche en Cancerologie de Lyon, Lyon, France. 
      Jenny.valladeau@lyon.unicancer.fr.
AD  - LabEx DEVweCAN, Lyon, France. Jenny.valladeau@lyon.unicancer.fr.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods Mol Biol
JT  - Methods in molecular biology (Clifton, N.J.)
JID - 9214969
SB  - IM
MH  - Humans
MH  - Adaptive Immunity
MH  - Antigen Presentation
MH  - *Dendritic Cells
MH  - Phenotype
MH  - *Tumor Microenvironment
OTO - NOTNLM
OT  - Antitumor immunity
OT  - Cancer
OT  - Conventional dendritic cells
OT  - Human dendritic cells
OT  - Monocyte-derived dendritic cells
OT  - Plasmacytoid dendritic cells
OT  - Single-cell RNA sequencing
OT  - Tumor
EDAT- 2023/03/12 06:00
MHDA- 2023/03/15 06:00
CRDT- 2023/03/11 11:17
PHST- 2023/03/11 11:17 [entrez]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/15 06:00 [medline]
AID - 10.1007/978-1-0716-2938-3_2 [doi]
PST - ppublish
SO  - Methods Mol Biol. 2023;2618:17-35. doi: 10.1007/978-1-0716-2938-3_2.