PMID- 36906259
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20240412
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 82
IP  - 4
DP  - 2023 Oct
TI  - In-hospital adverse events and recurrence in hospitalized patients with acute 
      pericarditis.
PG  - 268-273
LID - S0914-5087(23)00050-3 [pii]
LID - 10.1016/j.jjcc.2023.03.002 [doi]
AB  - BACKGROUND: Acute pericarditis occasionally requires invasive treatment, and may 
      recur after discharge. However, there are no studies on acute pericarditis in 
      Japan, and its clinical characteristics and prognosis are unknown. METHODS: This 
      was a single-center, retrospective cohort study of clinical characteristics, 
      invasive procedures, mortality, and recurrence in patients with acute 
      pericarditis hospitalized from 2010 to 2022. The primary in-hospital outcome was 
      adverse events (AEs), a composite of all-cause mortality and cardiac tamponade. 
      The primary outcome in the long-term analysis was hospitalization for recurrent 
      pericarditis. RESULTS: The median age of all 65 patients was 65.0 years 
      [interquartile range (IQR), 48.0-76.0 years], and 49 (75.3 %) were male. The 
      etiology of acute pericarditis was idiopathic in 55 patients (84.6 %), 
      collagenous in 5 (7.6 %), bacterial in 1 (1.5 %), malignant in 3 (4.6 %), and 
      related to previous open-heart surgery in 1 (1.5 %). Of the 8 patients (12.3 %) 
      with in-hospital AE, 1 (1.5 %) died during hospitalization and 7 (10.8 %) 
      developed cardiac tamponade. Patients with AE were less likely to have chest pain 
      (p = 0.011) but were more likely to have symptoms lasting 72 h after treatment 
      (p = 0.006), heart failure (p < 0.001), and higher levels of C-reactive protein 
      (p = 0.040) and B-type natriuretic peptide (p = 0.032). All patients complicated 
      with cardiac tamponade were treated with pericardial drainage or pericardiotomy. 
      We analyzed 57 patients for recurrent pericarditis after excluding 8 patients: 1 
      with in-hospital death, 3 with malignant pericarditis, 1 with bacterial 
      pericarditis, and 3 lost to follow-up. During a median follow-up of 2.5 years 
      (IQR 1.3-3.0 years), 6 patients (10.5 %) had recurrences requiring 
      hospitalization. The recurrence rate of pericarditis was not associated with 
      colchicine treatment or aspirin dose or titration. CONCLUSIONS: In acute 
      pericarditis requiring hospitalization, in-hospital AE and recurrence were each 
      observed in >10 % of patients. Further large studies on treatment are warranted.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Aikawa, Hirohiko
AU  - Aikawa H
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan; Department of Advanced Cardiovascular 
      Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 
      Japan.
FAU - Fujino, Masashi
AU  - Fujino M
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan. Electronic address: fujinom@ncvc.go.jp.
FAU - Murai, Kota
AU  - Murai K
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan; Department of Advanced Cardiovascular 
      Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 
      Japan.
FAU - Iwai, Takamasa
AU  - Iwai T
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Sawada, Kenichiro
AU  - Sawada K
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan; Department of Advanced Cardiovascular 
      Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 
      Japan.
FAU - Matama, Hideo
AU  - Matama H
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan; Department of Advanced Cardiovascular 
      Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 
      Japan.
FAU - Miura, Hiroyuki
AU  - Miura H
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Honda, Satoshi
AU  - Honda S
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Yoneda, Shuichi
AU  - Yoneda S
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Takagi, Kensuke
AU  - Takagi K
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Otsuka, Fumiyuki
AU  - Otsuka F
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Kataoka, Yu
AU  - Kataoka Y
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan; Department of Advanced Cardiovascular 
      Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 
      Japan.
FAU - Asaumi, Yasuhide
AU  - Asaumi Y
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Tahara, Yoshio
AU  - Tahara Y
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan.
FAU - Ogata, Soshiro
AU  - Ogata S
AD  - Department of Preventive Medicine and Epidemiology, NCVC, Suita, Osaka, Japan.
FAU - Nishimura, Kunihiro
AU  - Nishimura K
AD  - Department of Preventive Medicine and Epidemiology, NCVC, Suita, Osaka, Japan.
FAU - Tsujita, Kenichi
AU  - Tsujita K
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, Kumamoto, Japan.
FAU - Noguchi, Teruo
AU  - Noguchi T
AD  - Department of Cardiovascular Medicine, National Cerebral and Cardiovascular 
      Center (NCVC), Suita, Osaka, Japan; Department of Advanced Cardiovascular 
      Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230309
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
CIN - J Cardiol. 2024 Jan;83(1):65. PMID: 37506823
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Acute Disease
MH  - Cardiac Tamponade/epidemiology/therapy
MH  - Hospital Mortality
MH  - *Hospitalization
MH  - Japan/epidemiology
MH  - *Pericarditis/mortality/therapy
MH  - Recurrence
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Acute pericarditis
OT  - Cardiac tamponade
OT  - Pericardial drainage
OT  - Pericardiocentesis
OT  - Recurrent pericarditis
COIS- Declaration of competing interest Dr. Tsujita is a member of the editorial team 
      of the Journal of Cardiology. The other authors report no conflicts of interest 
      regarding the publication of this study.
EDAT- 2023/03/12 06:00
MHDA- 2023/08/21 06:42
CRDT- 2023/03/11 19:32
PHST- 2022/12/23 00:00 [received]
PHST- 2023/02/04 00:00 [revised]
PHST- 2023/02/16 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/03/12 06:00 [pubmed]
PHST- 2023/03/11 19:32 [entrez]
AID - S0914-5087(23)00050-3 [pii]
AID - 10.1016/j.jjcc.2023.03.002 [doi]
PST - ppublish
SO  - J Cardiol. 2023 Oct;82(4):268-273. doi: 10.1016/j.jjcc.2023.03.002. Epub 2023 Mar 
      9.