PMID- 36907828
OWN - NLM
STAT- MEDLINE
DCOM- 20230712
LR  - 20230718
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 25
IP  - 6
DP  - 2023 Jun
TI  - Diagnostic pathways to wild-type transthyretin amyloid cardiomyopathy: a 
      multicentre network study.
PG  - 845-853
LID - 10.1002/ejhf.2823 [doi]
AB  - AIM: Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) 
      remains poorly defined. A better characterization of pathways leading to 
      ATTRwt-CA diagnosis is of key importance, and potentially informative of disease 
      course and prognosis. The aim of this study was to describe the characteristics 
      of contemporary pathways leading to ATTRwt-CA diagnosis, and their potential 
      association with survival. METHODS AND RESULTS: This was a retrospective study of 
      patients diagnosed with ATTRwt-CA at 17 Italian referral centres for CA. Patients 
      were categorized into different 'pathways' according to the medical reason that 
      triggered the diagnosis of ATTRwt-CA (hypertrophic cardiomyopathy [HCM] pathway, 
      heart failure [HF] pathway, incidental imaging or incidental clinical pathway). 
      Prognosis was investigated with all-cause mortality as endpoint. Overall, 1281 
      ATTRwt-CA patients were included in the study. The diagnostic pathway leading to 
      ATTRwt-CA diagnosis was HCM in 7% of patients, HF in 51%, incidental imaging in 
      23%, incidental clinical in 19%. Patients in the HF pathway, as compared to the 
      others, were older and had a greater prevalence of New York Heart Association 
      (NYHA) class III-IV and chronic kidney disease. Survival was significantly worse 
      in the HF versus other pathways, but similar among the three others. In 
      multivariate model, older age at diagnosis, NYHA class III-IV and some 
      comorbidities but not the HF pathway were independently associated with worse 
      survival. CONCLUSIONS: Half of contemporary ATTRwt-CA diagnoses occur in a HF 
      setting. These patients had worse clinical profile and outcome than those 
      diagnosed either due to suspected HCM or incidentally, although prognosis 
      remained primarily related to age, NYHA functional class and comorbidities rather 
      than the diagnostic pathway itself.
CI  - (c) 2023 The Authors. European Journal of Heart Failure published by John Wiley & 
      Sons Ltd on behalf of European Society of Cardiology.
FAU - Tini, Giacomo
AU  - Tini G
AD  - Cardiology Unit, IRCCS OSpedale Policlinico San Martino, Genova, Italy.
AD  - Cardiology, Department of Clinical and Molecular Medicine, Sapienza University of 
      Rome, Sant'Andrea Hospital, Rome, Italy.
FAU - Milani, Paolo
AU  - Milani P
AD  - Department of Molecular Medicine, University of Pavia, Pavia, Italy.
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Zampieri, Mattia
AU  - Zampieri M
AD  - Tuscan Regional Amyloidosis Centre|, Careggi University Hospital, Florence, 
      Italy.
FAU - Caponetti, Angelo G
AU  - Caponetti AG
AD  - Cardiology Unit, St. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di 
      Bologna, Bologna, Italy.
AD  - Department of Experimental, Diagnostic and Specialty Medicine, University of 
      Bologna, Bologna, Italy.
FAU - Fabris, Francesca
AU  - Fabris F
AD  - Department of Molecular Medicine, University of Pavia, Pavia, Italy.
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Foli, Andrea
AU  - Foli A
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Argiro, Alessia
AU  - Argiro A
AD  - Tuscan Regional Amyloidosis Centre|, Careggi University Hospital, Florence, 
      Italy.
FAU - Mazzoni, Carlotta
AU  - Mazzoni C
AD  - Tuscan Regional Amyloidosis Centre|, Careggi University Hospital, Florence, 
      Italy.
FAU - Gagliardi, Christian
AU  - Gagliardi C
AD  - Cardiology Unit, St. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di 
      Bologna, Bologna, Italy.
AD  - European Reference Network for Rare, Low Prevalence and Complex Diseases of the 
      Heart-ERN GUARD-Heart.
FAU - Longhi, Simone
AU  - Longhi S
AD  - Cardiology Unit, St. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di 
      Bologna, Bologna, Italy.
AD  - European Reference Network for Rare, Low Prevalence and Complex Diseases of the 
      Heart-ERN GUARD-Heart.
FAU - Saturi, Giulia
AU  - Saturi G
AD  - Cardiology Unit, St. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di 
      Bologna, Bologna, Italy.
AD  - Department of Experimental, Diagnostic and Specialty Medicine, University of 
      Bologna, Bologna, Italy.
FAU - Vergaro, Giuseppe
AU  - Vergaro G
AD  - Interdisciplinary Center of Health Sciences, Scuola Superiore Sant'Anna, Pisa, 
      Italy.
AD  - Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
FAU - Aimo, Alberto
AU  - Aimo A
AD  - Interdisciplinary Center of Health Sciences, Scuola Superiore Sant'Anna, Pisa, 
      Italy.
AD  - Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
FAU - Russo, Domitilla
AU  - Russo D
AD  - Cardiology, Department of Clinical and Molecular Medicine, Sapienza University of 
      Rome, Sant'Andrea Hospital, Rome, Italy.
FAU - Varra, Guerino G
AU  - Varra GG
AD  - Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular 
      Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University 
      of Trieste, Trieste, Italy.
FAU - Serenelli, Matteo
AU  - Serenelli M
AD  - Cardiologic Center, University of Ferrara, Ferrara, Italy.
FAU - Fabbri, Gioele
AU  - Fabbri G
AD  - Cardiologic Center, University of Ferrara, Ferrara, Italy.
FAU - De Michieli, Laura
AU  - De Michieli L
AD  - Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of 
      Padua, Padua, Italy.
FAU - Palmiero, Giuseppe
AU  - Palmiero G
AD  - Inherited and Rare Cardiovascular Disease Unit, University of Campania "Luigi 
      Vanvitelli", AORN dei Colli, Monaldi Hospital, Naples, Italy.
FAU - Ciliberti, Giuseppe
AU  - Ciliberti G
AD  - Cardiology and Arrhythmology Clinic, University Hospital "Lancisi-Umberto 
      I-Salesi", Ancona, Italy.
AD  - Department of Biomedical Sciences and Public Health, Marche Polytechnic 
      University, Ancona, Italy.
FAU - Carigi, Samuela
AU  - Carigi S
AD  - Cardiology Unit, Infermi Hospital, Rimini, Italy.
FAU - Sessarego, Eugenio
AU  - Sessarego E
AD  - Cardiology Unit, IRCCS OSpedale Policlinico San Martino, Genova, Italy.
FAU - Mandoli, Giulia E
AU  - Mandoli GE
AD  - Department of Medical Biotechnologies, Division of Cardiology, University of 
      Siena, Siena, Italy.
FAU - Ricci Lucchi, Giulia
AU  - Ricci Lucchi G
AD  - Cardiology Unit, Ospedale Umberto I, Lugo-Ausl, Romagna, Italy.
FAU - Rella, Valeria
AU  - Rella V
AD  - Department of Cardiology, Istituto Auxologico Italiano IRCCS, San Luca Hospital, 
      Cardiomyopathy Unit, Milan, Italy.
FAU - Monti, Enrico
AU  - Monti E
AD  - Cardiology Unit, Ospedale di Forli, AUSL della Romagna, Forli, Italy.
FAU - Gardini, Elisa
AU  - Gardini E
AD  - Cardiology Unit, Ospedale di Forli, AUSL della Romagna, Forli, Italy.
FAU - Bartolotti, Michela
AU  - Bartolotti M
AD  - Cardiology Unit, Ospedale di Cesena, AUSL della Romagna, Cesena, Italy.
FAU - Crotti, Lia
AU  - Crotti L
AD  - Department of Cardiology, Istituto Auxologico Italiano IRCCS, San Luca Hospital, 
      Cardiomyopathy Unit, Milan, Italy.
AD  - Department of Medicine and Surgery, University Milano-Bicocca, Milan, Italy.
FAU - Merli, Elisa
AU  - Merli E
AD  - Cardiology Unit, Ospedale Umberto I, Lugo-Ausl, Romagna, Italy.
FAU - Mussinelli, Roberta
AU  - Mussinelli R
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Vianello, Pier Filippo
AU  - Vianello PF
AD  - Cardiology Unit, IRCCS OSpedale Policlinico San Martino, Genova, Italy.
FAU - Cameli, Matteo
AU  - Cameli M
AD  - Department of Medical Biotechnologies, Division of Cardiology, University of 
      Siena, Siena, Italy.
FAU - Marzo, Francesca
AU  - Marzo F
AD  - Cardiology Unit, Infermi Hospital, Rimini, Italy.
FAU - Guerra, Federico
AU  - Guerra F
AD  - Cardiology and Arrhythmology Clinic, University Hospital "Lancisi-Umberto 
      I-Salesi", Ancona, Italy.
AD  - Department of Biomedical Sciences and Public Health, Marche Polytechnic 
      University, Ancona, Italy.
FAU - Limongelli, Giuseppe
AU  - Limongelli G
AD  - European Reference Network for Rare, Low Prevalence and Complex Diseases of the 
      Heart-ERN GUARD-Heart.
AD  - Inherited and Rare Cardiovascular Disease Unit, University of Campania "Luigi 
      Vanvitelli", AORN dei Colli, Monaldi Hospital, Naples, Italy.
FAU - Cipriani, Alberto
AU  - Cipriani A
AD  - Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of 
      Padua, Padua, Italy.
AD  - Cardiology Unit, University Hospital of Padova, Padua, Italy.
FAU - Perlini, Stefano
AU  - Perlini S
AD  - Department of Molecular Medicine, University of Pavia, Pavia, Italy.
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Obici, Laura
AU  - Obici L
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Perfetto, Federico
AU  - Perfetto F
AD  - Tuscan Regional Amyloidosis Centre|, Careggi University Hospital, Florence, 
      Italy.
FAU - Autore, Camillo
AU  - Autore C
AD  - Cardiology, Department of Clinical and Molecular Medicine, Sapienza University of 
      Rome, Sant'Andrea Hospital, Rome, Italy.
AD  - IRCCS San Raffaele Cassino, Cassino, Italy.
FAU - Porto, Italo
AU  - Porto I
AD  - Cardiology Unit, IRCCS OSpedale Policlinico San Martino, Genova, Italy.
AD  - Department of Internal Medicine, University of Genova, Genoa, Italy.
FAU - Rapezzi, Claudio
AU  - Rapezzi C
AD  - Cardiologic Center, University of Ferrara, Ferrara, Italy.
AD  - GVM Care & Research, Maria Cecilia Hospital, Ravenna, Italy.
FAU - Sinagra, Gianfranco
AU  - Sinagra G
AD  - European Reference Network for Rare, Low Prevalence and Complex Diseases of the 
      Heart-ERN GUARD-Heart.
AD  - Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular 
      Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University 
      of Trieste, Trieste, Italy.
FAU - Merlo, Marco
AU  - Merlo M
AD  - European Reference Network for Rare, Low Prevalence and Complex Diseases of the 
      Heart-ERN GUARD-Heart.
AD  - Center for Diagnosis and Treatment of Cardiomyopathies, Cardiovascular 
      Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University 
      of Trieste, Trieste, Italy.
FAU - Musumeci, Beatrice
AU  - Musumeci B
AD  - Cardiology, Department of Clinical and Molecular Medicine, Sapienza University of 
      Rome, Sant'Andrea Hospital, Rome, Italy.
FAU - Emdin, Michele
AU  - Emdin M
AD  - Interdisciplinary Center of Health Sciences, Scuola Superiore Sant'Anna, Pisa, 
      Italy.
AD  - Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
FAU - Biagini, Elena
AU  - Biagini E
AD  - Cardiology Unit, St. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di 
      Bologna, Bologna, Italy.
AD  - European Reference Network for Rare, Low Prevalence and Complex Diseases of the 
      Heart-ERN GUARD-Heart.
FAU - Cappelli, Francesco
AU  - Cappelli F
AD  - Tuscan Regional Amyloidosis Centre|, Careggi University Hospital, Florence, 
      Italy.
FAU - Palladini, Giovanni
AU  - Palladini G
AD  - Department of Molecular Medicine, University of Pavia, Pavia, Italy.
AD  - Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura 
      a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy.
FAU - Canepa, Marco
AU  - Canepa M
AUID- ORCID: 0000-0001-9063-5576
AD  - Cardiology Unit, IRCCS OSpedale Policlinico San Martino, Genova, Italy.
AD  - Department of Internal Medicine, University of Genova, Genoa, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230315
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 0 (Prealbumin)
SB  - IM
CIN - Eur J Heart Fail. 2023 Jun;25(6):854-856. PMID: 37191114
MH  - Humans
MH  - Prealbumin/genetics/metabolism
MH  - *Amyloid Neuropathies, Familial/diagnosis/epidemiology/complications
MH  - Retrospective Studies
MH  - *Heart Failure/diagnosis/epidemiology/complications
MH  - *Cardiomyopathies/diagnosis/epidemiology/complications
OTO - NOTNLM
OT  - Cardiac amyloidosis
OT  - Epidemiology of cardiac amyloidosis
OT  - Tafamidis
OT  - Wild-type transthyretin cardiac amyloidosis
EDAT- 2023/03/13 06:00
MHDA- 2023/07/12 06:42
CRDT- 2023/03/12 23:32
PHST- 2023/02/23 00:00 [revised]
PHST- 2022/10/26 00:00 [received]
PHST- 2023/02/26 00:00 [accepted]
PHST- 2023/07/12 06:42 [medline]
PHST- 2023/03/13 06:00 [pubmed]
PHST- 2023/03/12 23:32 [entrez]
AID - 10.1002/ejhf.2823 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2023 Jun;25(6):845-853. doi: 10.1002/ejhf.2823. Epub 2023 Mar 
      15.