PMID- 36908593
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Inflammatory markers and the risk of idiopathic sudden sensorineural hearing 
      loss: A Mendelian randomization study.
PG  - 1111255
LID - 10.3389/fneur.2023.1111255 [doi]
LID - 1111255
AB  - BACKGROUND: Observational studies suggest that inflammatory markers may increase 
      the risk of idiopathic sudden sensorineural hearing loss (ISSHL). However, the 
      causal relationship between the two has not been established. We sought to assess 
      the possible causal effect between several genetically predicted inflammatory 
      markers and ISSHL by Mendelian random (MR) analysis. METHODS: We extracted single 
      nucleotide polymorphisms (SNPs) associated with C-reactive protein (CRP), Tumor 
      necrosis factor-alpha (TNF-alpha), and fibrinogen from abstract data from the European 
      Individual Large genome-wide association studies (GWAS). Genetic data for ISSHL 
      were obtained from the FinnGen study (n = 196,592). Effect estimates were 
      assessed using inverse variance weighting (IVW) as the primary method. 
      Sensitivity analyses were performed using weighted median, MR-Egger, and 
      MR-PRESSO to evaluate heterogeneity and pleiotropy. RESULTS: In the 
      random-effects IVW approach, there was a significant causal relationship between 
      genetic susceptibility to CRP levels and ISSHL (OR = 1.23, 95% CI = 1.02-1.49, P 
      = 0.03). In contrast, genetic TNF-alpha and fibrinogen were not risked factors for 
      ISSHL (OR = 1.14, 95% CI = 0.88-1.49, P = 0.30; OR = 0.74, 95% CI = 0.07-7.96, P 
      = 0.30; OR = 1.05, 95% CI = 0.88-1.25, P = 0.59). All the above results were 
      consistent after validation by different Mendelian randomization methods and 
      sensitivity analyses. CONCLUSION: This Mendelian randomization study provides 
      causal evidence that CRP is a risk factor for ISSHL, while TNF-alpha and fibrinogen 
      do not increase the risk for ISSHL Introduction.
CI  - Copyright (c) 2023 Zhou, Chen, Yuan, Xia, Zhang, Zhang, Chen and Lin.
FAU - Zhou, Tingfeng
AU  - Zhou T
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Chen, Mengjiao
AU  - Chen M
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Yuan, Ziyi
AU  - Yuan Z
AD  - Wenzhou Medical University, Wenzhou, China.
FAU - Xia, Zhigang
AU  - Xia Z
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Zhang, Shurou
AU  - Zhang S
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Zhang, Ziheng
AU  - Zhang Z
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Chen, Huanqi
AU  - Chen H
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
FAU - Lin, Renyu
AU  - Lin R
AD  - Department of Otolaryngology, First Affiliated Hospital of Wenzhou Medical 
      University, Wenzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20230222
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC9992207
OTO - NOTNLM
OT  - C-reactive protein
OT  - Mendelian randomization
OT  - TNF-alpha
OT  - fibrinogen
OT  - idiopathic sudden sensorineural hearing loss
OT  - inflammation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/14 06:00
MHDA- 2023/03/14 06:01
PMCR- 2023/02/22
CRDT- 2023/03/13 03:48
PHST- 2022/11/29 00:00 [received]
PHST- 2023/02/03 00:00 [accepted]
PHST- 2023/03/13 03:48 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/14 06:01 [medline]
PHST- 2023/02/22 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1111255 [doi]
PST - epublish
SO  - Front Neurol. 2023 Feb 22;14:1111255. doi: 10.3389/fneur.2023.1111255. 
      eCollection 2023.