PMID- 36909048
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 2
DP  - 2023 Feb
TI  - High-Risk Human Papillomavirus Infection in Squamous Cell Carcinoma of the 
      Larynx: A Study From a Tertiary Care Center in North India.
PG  - e34760
LID - 10.7759/cureus.34760 [doi]
LID - e34760
AB  - Background Human papillomavirus (HPV) 16/18 infection has been considered as an 
      important etiological factor for laryngeal carcinoma. Considering its impact on 
      prognosis, it is important to understand the true prevalence of HPV-associated 
      laryngeal squamous cell carcinoma (LSCC) in the northeast region of India. 
      Materials and methods A prospective observational study was conducted among 
      patients with laryngeal squamous cell carcinoma in the department of 
      otolaryngology of King George's Medical University (KGMU), Lucknow. Results In 
      this study, the total number of cases was 62. HPV 16/18 positivity was higher 
      (p=0.02) among the age group 31-40 years (40%) as compared to above 50 years 
      (3.3%). HPV positivity was higher among females (50%) as compared to males 
      (12.5%). Out of 34 tobacco smokers, HPV positivity was seen in 20.6% as compared 
      to no positivity among patients without any history of addiction. HPV positivity 
      was found in 19.6% of supraglottic cancer and no positivity among glottic cancer. 
      HPV positivity was higher among the T1 stage of supraglottic carcinoma (40%) as 
      compared to T3 (17.4%). In glottic cases, HPV positivity was nil in all T stages. 
      Conclusion The association of tumor HPV status with laryngeal squamous cell 
      carcinoma in females and young patients (<50 years) observed in our study is 
      consistent with prior studies, and this reflects that HPV status should be 
      considered in the design or analysis for the treatment of laryngeal cancer. We 
      tried to highlight the importance of diagnosing HPV-positive laryngeal squamous 
      cell carcinoma at early stages of the disease and also added information about 
      the prevalence of HPV-positive LSCC in this zone of the country. We have observed 
      that laryngeal carcinoma from tobacco smokers contains transcriptionally active 
      HPV and hence may act as a risk factor or act synergistically with HPV infection. 
      Further studies with larger sample size are needed to clearly establish the 
      association of HPV in laryngeal squamous cell carcinoma and its impact on disease 
      prognosis.
CI  - Copyright (c) 2023, Ghosh et al.
FAU - Ghosh, Shreshtha
AU  - Ghosh S
AD  - Pathology, Kalyan Singh Super Speciality Cancer Institute, Lucknow, IND.
FAU - Kumar, Sanjeev
AU  - Kumar S
AD  - Otolaryngology, Rani Durgavati Medical College (RDMC), Banda, IND.
FAU - Chaudhary, Rajiv
AU  - Chaudhary R
AD  - Otolaryngology, Amaya ENT Clinic, Fatehpur, IND.
FAU - Guha, Priyadarshini
AU  - Guha P
AD  - Pathology, Kalyan Singh Super Speciality Cancer Institute, Lucknow, IND.
LA  - eng
PT  - Journal Article
DEP - 20230208
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10005857
OTO - NOTNLM
OT  - head and neck oncology
OT  - high-risk papillomavirus
OT  - pcr (polymerase chain reaction)
OT  - polymerase chain reaction (pcr)
OT  - smoking tobacco
OT  - squamous cell carcinoma of the larynx
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/14 06:00
MHDA- 2023/03/14 06:01
PMCR- 2023/02/08
CRDT- 2023/03/13 03:54
PHST- 2023/02/08 00:00 [accepted]
PHST- 2023/03/13 03:54 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/14 06:01 [medline]
PHST- 2023/02/08 00:00 [pmc-release]
AID - 10.7759/cureus.34760 [doi]
PST - epublish
SO  - Cureus. 2023 Feb 8;15(2):e34760. doi: 10.7759/cureus.34760. eCollection 2023 Feb.