PMID- 36910436
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2536-4553 (Electronic)
IS  - 2148-4902 (Print)
IS  - 2536-4553 (Linking)
VI  - 10
IP  - 1
DP  - 2023
TI  - Relationship of HLA-B alleles on susceptibility to and protection from HIV 
      infection in Turkish population.
PG  - 67-73
LID - 10.14744/nci.2021.00018 [doi]
AB  - OBJECTIVE: Many human leukocyte antigen (HLA)-B alleles are associated with an 
      increased risk of Acquired Immune Deficiency Syndrome (AIDS) and Human 
      Immunodeficiency Virus (HIV) progression; however, their distribution varies 
      among different racial/ethnic groups. Abacavir used in the treatment of AIDS 
      significantly increases the risk of hypersensitivity reactions in patients with 
      HLA-B*57:01. The aim of this study was to determine the distribution of 
      HIV-associated HLA-B subgroups (high and low resolution) and HLA-B*57:01 
      associated with Abacavir sensitivity in Turkiye. METHODS: This retrospective 
      case-control study consisted of 416 (F/M:111/305) HIV positive patients and 416 
      (F/M:111/305) healthy controls. HLA-B alleles were identified using Luminex based 
      low-resolution method and further subgrouped by sequence-based high-resolution 
      typing. RESULTS: Our data showed that in patients with HIV-1 infection, HLA-B*15, 
      *35, and *51 allele frequencies were higher, while the HLA-B*07, *14 and *55 
      allele frequencies were lower as compared to the controls. It was determined that 
      HLA-B*15:01, *35:01, *35:08, and *51:01 alleles frequencies were higher in the 
      patients with HIV-1 infection compared to the controls as HLA-B*07:02, *14:01, 
      *44:01, and *55:01 allele frequencies were detected low. HLA-B*57:01 allele 
      positivity, which is important in Abacavir hypersensitivity, was lower than 
      controls, and this difference was not statistically significant. CONCLUSION: Our 
      results suggest that, HLA-B*07, *14, and *55 alleles and HLA-B*07:02, *14:01, 
      *44:01, and *55:01 subgroups might have a protective effect, while HLA-B*15, *35, 
      and *51 alleles and HLA-B*15:01, *35:01, *35:08, and *51:01 subgroups might play 
      a role in susceptibility to HIV-1 infection.
CI  - (c) Copyright 2023 by Istanbul Provincial Directorate of Health.
FAU - Darbas, Sule
AU  - Darbas S
AD  - Department of Medical Biology and Genetics, Akdeniz University Faculty of 
      Medicine, Antalya, Turkiye.
FAU - Inan, Dilara
AU  - Inan D
AD  - Department of Infectious Diseases, Akdeniz University Faculty of Medicine, 
      Antalya, Turkiye.
FAU - Kilinc, Yahya
AU  - Kilinc Y
AD  - Department of Medical Biology and Genetics, Akdeniz University Faculty of 
      Medicine, Antalya, Turkiye.
FAU - Arslan, Habibe Sema
AU  - Arslan HS
AD  - Department of Medical Biology and Genetics, Akdeniz University Faculty of 
      Medicine, Antalya, Turkiye.
FAU - Ucar, Fahri
AU  - Ucar F
AD  - Department of Medical Biology and Genetics, Akdeniz University Faculty of 
      Medicine, Antalya, Turkiye.
FAU - Boylubay, Ozaydin
AU  - Boylubay O
AD  - Isparta Provincial Health Directorate Central Community Health Center, Isparta, 
      Turkiye.
FAU - Koksoy, Sadi
AU  - Koksoy S
AD  - Department of Medical Microbiology, Akdeniz University Faculty of Medicine, 
      Antalya, Turkiye.
FAU - Mutlu, Esvet
AU  - Mutlu E
AD  - Department of Medical Microbiology, Akdeniz University Faculty of Medicine, 
      Antalya, Turkiye.
FAU - Yucel, Burcu
AU  - Yucel B
AD  - Department of Medical Biology, Istanbul Medeniyet University Faculty of Medicine, 
      Istanbul, Turkiye.
FAU - Ekinci, Nurten Sayin
AU  - Ekinci NS
AD  - Department of Medical Biology and Genetics, Akdeniz University Faculty of 
      Medicine, Antalya, Turkiye.
LA  - eng
PT  - Journal Article
DEP - 20221213
PL  - Turkey
TA  - North Clin Istanb
JT  - Northern clinics of Istanbul
JID - 101684520
PMC - PMC9996654
OTO - NOTNLM
OT  - Antiretroviral therapy
OT  - HIV
OT  - HLA-B alleles distribution
OT  - hypersensitivity reaction
COIS- No conflict of interest was declared by the authors.
EDAT- 2023/03/14 06:00
MHDA- 2023/03/14 06:01
PMCR- 2022/12/13
CRDT- 2023/03/13 04:12
PHST- 2021/06/22 00:00 [received]
PHST- 2021/08/02 00:00 [revised]
PHST- 2021/08/19 00:00 [accepted]
PHST- 2023/03/13 04:12 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/14 06:01 [medline]
PHST- 2022/12/13 00:00 [pmc-release]
AID - NCI-10-067 [pii]
AID - 10.14744/nci.2021.00018 [doi]
PST - epublish
SO  - North Clin Istanb. 2022 Dec 13;10(1):67-73. doi: 10.14744/nci.2021.00018. 
      eCollection 2023.