PMID- 36910518
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 10
DP  - 2023
TI  - Early vascular healing after neXt-generation drug-eluting stent implantation in 
      Patients with non-ST Elevation acute Coronary syndrome based on optical coherence 
      Tomography guidance and evaluation (EXPECT): study protocol for a randomized 
      controlled trial.
PG  - 1003546
LID - 10.3389/fcvm.2023.1003546 [doi]
LID - 1003546
AB  - BACKGROUND: There is limited evidence about vessel wall healing response 
      following implantation of next-generation drug-eluting stents (DES) in patients 
      admitted with a non-ST elevation acute coronary syndrome (NSTE-ACS). Cumulative 
      data indicate that optical coherence tomography (OCT) imaging can optimize 
      percutaneous coronary intervention results and expedite stent endothelialization 
      in the general population but there is lack of data in NSTE-ACS patients. 
      METHODS: The EXPECT study is an investigator-initiated, prospective, randomized 
      trial to assess early vascular healing response following next-generation DES 
      implantation in patients admitted with NSTE-ACS based on OCT guidance and 
      evaluation. Sixty patients are randomized at 1:1:1 ratio to OCT-guided 
      percutaneous coronary intervention (PCI) with 3-month follow-up OCT imaging (O3 
      group, n = 20), to angiography-guided PCI with 3-month follow-up OCT imaging (A3 
      group, n = 20) and to angiography-guided PCI with 6-month follow-up OCT imaging 
      (A6 group, n = 20). The primary endpoint of the study is stent strut coverage 
      rate at 3- or 6- month follow-up in the studied groups. The secondary endpoints 
      of the study include OCT imaging endpoints, clinical endpoints, and molecular 
      biology endpoints at the different time points. The clinical endpoints comprised 
      of major cardiovascular adverse events and individual components. The molecular 
      biology endpoints comprised of lipid levels and the levels of inflammatory 
      indicators. DISCUSSION: The findings of the EXPECT study are anticipated to 
      provide novel insights into vessel wall healing in NSTE-ACS population following 
      implantation of next-generation DES, underscore the value of OCT imaging in 
      expediting strut coverage in this setting, and explore the potential of an early 
      discontinuation of dual antiplatelet therapy (DAPT) in this population. CLINICAL 
      TRIAL REGISTRATION: ClinicalTrials.gov, NCT04375319.
CI  - Copyright (c) 2023 Zhu, Liang, Parasa, Li, Li, Chang, Ma, Feng, Wang, Xu, Bourantas 
      and Zhang.
FAU - Zhu, Yong-Xiang
AU  - Zhu YX
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Liang, Li
AU  - Liang L
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Parasa, Ramya
AU  - Parasa R
AD  - Department of Cardiology, Barts Heart Center, Barts Health NHS Trust, London, 
      United Kingdom.
AD  - Cardiovascular Devices Hub, Centre for Cardiovascular Medicine and Devices, 
      William Harvey Research Institute, Queen Mary University of London, London, 
      United Kingdom.
FAU - Li, Zheng
AU  - Li Z
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Li, Qian
AU  - Li Q
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Chang, Shang
AU  - Chang S
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Ma, Wen-Rui
AU  - Ma WR
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Feng, Si-Li
AU  - Feng SL
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
FAU - Wang, Yang
AU  - Wang Y
AD  - Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Xu, Bo
AU  - Xu B
AD  - Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Bourantas, Christos V
AU  - Bourantas CV
AD  - Department of Cardiology, Barts Heart Center, Barts Health NHS Trust, London, 
      United Kingdom.
AD  - Cardiovascular Devices Hub, Centre for Cardiovascular Medicine and Devices, 
      William Harvey Research Institute, Queen Mary University of London, London, 
      United Kingdom.
FAU - Zhang, Yao-Jun
AU  - Zhang YJ
AD  - Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou Medical 
      University, Xuzhou, China.
LA  - eng
SI  - ClinicalTrials.gov/NCT04375319
PT  - Journal Article
DEP - 20230223
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9995825
OTO - NOTNLM
OT  - early vascular healing
OT  - non-ST elevation acute coronary syndrome
OT  - optical coherence tomography
OT  - percutaneous coronary intervention
OT  - stent struts coverage
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The handling editor TG declared a past collaboration with 
      the author CB.
EDAT- 2023/03/14 06:00
MHDA- 2023/03/14 06:01
PMCR- 2023/02/23
CRDT- 2023/03/13 04:13
PHST- 2022/07/26 00:00 [received]
PHST- 2023/02/06 00:00 [accepted]
PHST- 2023/03/13 04:13 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/14 06:01 [medline]
PHST- 2023/02/23 00:00 [pmc-release]
AID - 10.3389/fcvm.2023.1003546 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2023 Feb 23;10:1003546. doi: 10.3389/fcvm.2023.1003546. 
      eCollection 2023.