PMID- 36911543
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 1011-6842 (Print)
IS  - 1011-6842 (Linking)
VI  - 39
IP  - 2
DP  - 2023 Mar
TI  - The Roles of Aerobic Exercise and Folate Supplementation in 
      Hyperhomocysteinemia-Accelerated Atherosclerosis.
PG  - 309-318
LID - 10.6515/ACS.202303_39(2).20221027A [doi]
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy) is an independent risk factor for 
      atherosclerosis. Effective interventions to reduce HHcy-accelerated 
      atherosclerosis are required. OBJECTIVES: This study aimed to investigate the 
      effects of aerobic exercise (AE) and folate (FA) supplementation on plasma 
      homocysteine (Hcy) level and atherosclerosis development in a mouse model. 
      METHODS: Six-week-old female apoE-/- mice were grouped into five groups (N = 
      6-8): HHcy (1.8 g/L DL-homocysteine (DL-Hcy) in drinking water), HHcy + AE (1.8 
      g/L DL-Hcy and aerobic exercise training on a treadmill), HHcy + FA (1.8 g/L 
      DL-Hcy and 0.006% folate in diet), HHcy + AE + FA (1.8 g/L DL-Hcy, 0.006% folate, 
      and aerobic exercise training on a treadmill), and a control group (regular water 
      and diet). All treatment was sustained for 8 weeks. Triglyceride, cholesterol, 
      lipoprotein, and Hcy levels were determined enzymatically. Plaque and monocyte 
      chemoattractant protein-1 (MCP-1) expression levels in mouse aortic roots were 
      evaluated by immunohistochemistry. RESULTS: Compared to the HHcy group (18.88 +/- 
      6.13 mumol/L), plasma Hcy concentration was significantly reduced in the HHcy + AE 
      (14.79 +/- 3.05 mumol/L, p = 0.04), HHcy + FA (9.4 +/- 3.85 mumol/L, p < 0.001), and 
      HHcy + AE + FA (9.33 +/- 2.21 mumol/L, p < 0.001) groups. Significantly decreased 
      aortic root plaque area and plaque burden were found in the HHcy + AE and HHcy + 
      AE + FA groups compared to those in the HHcy group (both p < 0.05). Plasma MCP-1 
      level and MCP-1 expression in atherosclerotic lesions were significantly 
      decreased in the HHcy + AE and HHcy + AE + FA groups compared to the HHcy group 
      (all p < 0.05). CONCLUSIONS: AE reduced atherosclerosis development in HHcy 
      apoE-/- mice independently of reducing Hcy levels. FA supplementation decreased 
      plasma Hcy levels without attenuating HHcy-accelerated atherosclerosis. AE and FA 
      supplementation have distinct mechanisms in benefiting atherosclerosis.
FAU - Zhong, Xingming
AU  - Zhong X
AD  - School of Kinesiology and Health, Capital University of Physical Education and 
      Sports.
FAU - He, Rong
AU  - He R
AD  - Department of Cardiology, Beijing Tsinghua Changgung Hospital, School of Clinical 
      Medicine, Tsinghua University.
FAU - You, Shaohua
AU  - You S
AD  - School of Kinesiology and Health, Capital University of Physical Education and 
      Sports.
FAU - Liu, Bo
AU  - Liu B
AD  - Department of Physiology, Peking University Health Center.
FAU - Wang, Xiujie
AU  - Wang X
AD  - School of Kinesiology and Health, Capital University of Physical Education and 
      Sports.
FAU - Mao, Jieming
AU  - Mao J
AD  - Department of Cardiology, Peking University Third Hospital, Beijing, China.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Acta Cardiol Sin
JT  - Acta Cardiologica Sinica
JID - 101687085
PMC - PMC9999187
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Atherosclerosis
OT  - Folate
OT  - Homocysteine
OT  - Hyperhomocysteinemia
EDAT- 2023/03/14 06:00
MHDA- 2023/03/14 06:01
PMCR- 2023/03/01
CRDT- 2023/03/13 04:27
PHST- 2022/04/20 00:00 [received]
PHST- 2022/10/27 00:00 [accepted]
PHST- 2023/03/13 04:27 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/14 06:01 [medline]
PHST- 2023/03/01 00:00 [pmc-release]
AID - 10.6515/ACS.202303_39(2).20221027A [doi]
PST - ppublish
SO  - Acta Cardiol Sin. 2023 Mar;39(2):309-318. doi: 
      10.6515/ACS.202303_39(2).20221027A.