PMID- 36911589
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230314
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 3
DP  - 2023 Mar
TI  - Increased Risk of Non-Alcoholic Steatohepatitis in Patients With Inflammatory 
      Bowel Disease: A Population-Based Study.
PG  - e35854
LID - 10.7759/cureus.35854 [doi]
LID - e35854
AB  - Background and objective The global health burden of inflammatory bowel disease 
      (IBD) stems from its increasing incidence over the years. Comprehensive studies 
      on the topic hypothesize that IBD plays a more dominant in the development of 
      non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis 
      (NASH). In light of this, we conducted this study with the aim of assessing the 
      prevalence and risk factors of developing NASH in patients who have had a 
      diagnosis of ulcerative colitis (UC) and Crohn's disease (CD). Methodology A 
      validated multicenter and research platform database of more than 360 hospitals 
      from 26 different healthcare systems across the United States from 1999 to 
      September 2022 was utilized for conducting this study. Patients aged 18-65 years 
      were included. Pregnant patients and individuals diagnosed with alcohol use 
      disorder were excluded. The risk of developing NASH was calculated using a 
      multivariate regression analysis to account for potential confounding variables 
      including male gender, hyperlipidemia, hypertension, type 2 diabetes mellitus 
      (T2DM), and obesity. A two-sided p-value <0.05 was considered statistically 
      significant, and all statistical analyses were performed using R version 4.0.2 (R 
      Foundation for Statistical Computing, Vienna, Austria, 2008). Results A total of 
      79,346,259 individuals were screened in the database and 46,667,720 were selected 
      for the final analysis based on the inclusion and exclusion criteria. Using 
      multivariate regression analysis, the risk of developing NASH among patients with 
      UC and CD was calculated. The odds of having NASH among patients with UC was 2.37 
      (95% CI: 2.17-2.60, p<0.001). Similarly, the odds of having NASH were high in 
      patients with CD as well, at 2.79 (95% CI: 2.58-3.02, p<0.001). Conclusion Based 
      on our findings, patients with IBD have an increased prevalence and higher odds 
      of developing NASH after controlling for common risk factors. We believe that a 
      complex pathophysiological relationship exists between both disease processes. 
      Further research is required to establish appropriate screening times to enable 
      earlier disease identification and thereby improve patient outcomes.
CI  - Copyright (c) 2023, Onwuzo et al.
FAU - Onwuzo, Somtochukwu
AU  - Onwuzo S
AD  - Internal Medicine, Cleveland Clinic Foundation, Cleveland, USA.
FAU - Boustany, Antoine
AU  - Boustany A
AD  - Internal Medicine, Cleveland Clinic Foundation, Cleveland, USA.
FAU - Saleh, Mustafa
AU  - Saleh M
AD  - Faculty of Medical Sciences, Lebanese University, Beirut, LBN.
FAU - Gupta, Riya
AU  - Gupta R
AD  - Faculty of Medicine, Kasturba Medical College, Mangalore, IND.
FAU - Onwuzo, Chidera
AU  - Onwuzo C
AD  - Internal Medicine, General Hospital Lagos Island, Lagos, NGA.
FAU - Mascarenhas Monteiro, Jessy
AU  - Mascarenhas Monteiro J
AD  - Internal Medicine, Ross University School of Medicine, Bridgetown, BRB.
FAU - Lawrence, Favour
AU  - Lawrence F
AD  - Internal Medicine, General Hospital Lagos Island, Lagos, NGA.
FAU - Obuekwe, Chukwuemeka
AU  - Obuekwe C
AD  - Internal Medicine, Obafemi Awolowo University Teaching Hospital, Osun, NGA.
FAU - Morani, Zoya
AU  - Morani Z
AD  - Medicine, Washington University of Health and Science, San Pedro, BLZ.
FAU - Asaad, Imad
AU  - Asaad I
AD  - Internal Medicine, Cleveland Clinic Foundation, Cleveland, USA.
LA  - eng
PT  - Journal Article
DEP - 20230307
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9995222
OTO - NOTNLM
OT  - crohn;s disease
OT  - large-database
OT  - non-alcoholic steatohepatitis
OT  - population based study
OT  - ulcerative colitis
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/03/14 06:00
MHDA- 2023/03/14 06:01
PMCR- 2023/03/07
CRDT- 2023/03/13 04:28
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/03/13 04:28 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/14 06:01 [medline]
PHST- 2023/03/07 00:00 [pmc-release]
AID - 10.7759/cureus.35854 [doi]
PST - epublish
SO  - Cureus. 2023 Mar 7;15(3):e35854. doi: 10.7759/cureus.35854. eCollection 2023 Mar.