PMID- 36912579
OWN - NLM
STAT- MEDLINE
DCOM- 20230519
LR  - 20230524
IS  - 2198-3844 (Electronic)
IS  - 2198-3844 (Linking)
VI  - 10
IP  - 14
DP  - 2023 May
TI  - Genomic Landscape and Potential Regulation of RNA Editing in Drug Resistance.
PG  - e2207357
LID - 10.1002/advs.202207357 [doi]
LID - 2207357
AB  - Adenosine-to-inosine RNA editing critically affects the response of cancer 
      therapies. However, comprehensive identification of drug resistance-related RNA 
      editing events and systematic understanding of how RNA editing mediates 
      anticancer drug resistance remain unclear. Here, 7157 differential editing sites 
      (DESs) are identified from 98 127 informative RNA editing sites in tumor tissues, 
      many of which are validated in cancer cell lines. Diverse editing patterns of 
      DESs are discovered in resistant samples, which could not be fully explained by 
      adenosine deaminase acting on RNA enzymes. Some RNA-binding proteins are 
      identified that potentially regulate these editing events. Notably, the DESs are 
      significantly enriched in 3'-untranslated regions (3'-UTRs). The impact of DESs 
      in 3'-UTR on the microRNA (miRNA) regulations is explored, and some triplets 
      (DES, miRNA, and gene) that may contribute to drug resistance are identified. In 
      addition, it is determined that the functions of genes enriched with DESs are 
      associated with drug resistance, such as apoptosis, drug metabolism, and DNA 
      synthesis involved in DNA repair. An online resource 
      (http://www.jianglab.cn/REDR/) to support convenient retrieval of DESs is also 
      built. The findings reveal the landscape and potential regulatory mechanism of 
      RNA editing in drug resistance, providing new therapeutic targets for reversing 
      drug resistance.
CI  - (c) 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
FAU - Zhou, Xu
AU  - Zhou X
AUID- ORCID: 0000-0002-2556-6479
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing, 211106, P. R. China.
FAU - Mitra, Ramkrishna
AU  - Mitra R
AUID- ORCID: 0000-0002-6181-9066
AD  - Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Cancer 
      Center, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA.
FAU - Hou, Fei
AU  - Hou F
AUID- ORCID: 0000-0001-8681-5355
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing, 211106, P. R. China.
FAU - Zhou, Shunheng
AU  - Zhou S
AUID- ORCID: 0000-0003-0299-2667
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing, 211106, P. R. China.
FAU - Wang, Lihong
AU  - Wang L
AUID- ORCID: 0000-0002-6715-2944
AD  - Department of Pathophysiology, School of Medicine, Southeast University, Nanjing, 
      210009, P. R. China.
FAU - Jiang, Wei
AU  - Jiang W
AUID- ORCID: 0000-0003-1591-4721
AD  - Department of Biomedical Engineering, Nanjing University of Aeronautics and 
      Astronautics, Nanjing, 211106, P. R. China.
LA  - eng
GR  - 62172213/National Natural Science Foundation of China/
GR  - 81972478/National Natural Science Foundation of China/
GR  - 61872183/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230313
PL  - Germany
TA  - Adv Sci (Weinh)
JT  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
JID - 101664569
RN  - K72T3FS567 (Adenosine)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - *RNA Editing/genetics
MH  - Adenosine/genetics
MH  - *MicroRNAs/genetics
MH  - Genomics
PMC - PMC10190536
OTO - NOTNLM
OT  - RNA editing
OT  - RNA-binding proteins
OT  - drug resistance
OT  - microRNA regulations
OT  - therapeutic targets
COIS- The authors declare no conflict of interest.
EDAT- 2023/03/14 06:00
MHDA- 2023/05/19 06:42
PMCR- 2023/03/13
CRDT- 2023/03/13 09:22
PHST- 2023/01/31 00:00 [revised]
PHST- 2022/12/12 00:00 [received]
PHST- 2023/05/19 06:42 [medline]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/13 09:22 [entrez]
PHST- 2023/03/13 00:00 [pmc-release]
AID - ADVS5308 [pii]
AID - 10.1002/advs.202207357 [doi]
PST - ppublish
SO  - Adv Sci (Weinh). 2023 May;10(14):e2207357. doi: 10.1002/advs.202207357. Epub 2023 
      Mar 13.