PMID- 36912588
OWN - NLM
STAT- MEDLINE
DCOM- 20230927
LR  - 20230927
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 99
IP  - 10
DP  - 2023
TI  - Function of stem cells in radiation-induced damage.
PG  - 1483-1494
LID - 10.1080/09553002.2023.2188935 [doi]
AB  - PURPOSE: The aim of this review is to discuss previous studies on the function of 
      stem cells in radiation-induced damage, and the factors affecting these 
      processes, in the hope of improving our understanding of the different stem cells 
      and the communication networks surrounding them. This is essential for the 
      development of effective stem cell-based therapies to regenerate or replace 
      normal tissues damaged by radiation. CONCLUSION: In salivary glands, 
      senescence-associated cytokines and inflammation-associated cells have a greater 
      effect on stem cells. In the intestinal glands, Paneth cells strongly affect stem 
      cell-mediated tissue regeneration after radiation treatment. In the pancreas, 
      beta-cells as well as protein C receptor positive (Procr) cells are expected to be 
      key cells in the treatment of diabetes. In the bone marrow, a variety of 
      cytokines such as CXC-chemokine ligand 12 (CXCL12) and stem cell factor (SCF), 
      contribute to the functional recovery of hematopoietic stem cells after 
      irradiation.
FAU - Liu, Yingtong
AU  - Liu Y
AD  - School of Medical and Life Sciences, Chengdu University of Traditional Chinese 
      Medicine, and Cancer Center, West China Hospital of Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Liu, Zheran
AU  - Liu Z
AD  - Department of Biotherapy, Cancer Center, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Hu, Liqiang
AU  - Hu L
AD  - West China-California Research Center for Predictive Intervention Medicine, West 
      China Hospital, Sichuan University, Chengdu, China.
FAU - He, Ling
AU  - He L
AD  - Department of Biotherapy, Cancer Center, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Yang, Lianlian
AU  - Yang L
AD  - Department of Biotherapy, Cancer Center, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Qin, Zijian
AU  - Qin Z
AD  - Department of Biotherapy, Cancer Center, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Xie, Yuping
AU  - Xie Y
AD  - Department of Oncology, Chengdu First People's Hospital, Chengdu, Sichuan, China.
FAU - Peng, Xingchen
AU  - Peng X
AD  - Department of Biotherapy, Cancer Center, West China Hospital of Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Dai, Lei
AU  - Dai L
AD  - State Key Laboratory of Biotherapy/Collaborative Innovation Center for 
      Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230323
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Cytokines)
SB  - IM
MH  - *Hematopoietic Stem Cells/physiology
MH  - *Bone Marrow/radiation effects
MH  - Salivary Glands/radiation effects
MH  - Cytokines/metabolism
OTO - NOTNLM
OT  - Radiotherapy
OT  - hematopoietic stem cells (HSCs)
OT  - intestinal glands
OT  - pancreas
OT  - salivary glands
OT  - stem cells
EDAT- 2023/03/14 06:00
MHDA- 2023/09/27 06:42
CRDT- 2023/03/13 09:32
PHST- 2023/09/27 06:42 [medline]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/13 09:32 [entrez]
AID - 10.1080/09553002.2023.2188935 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2023;99(10):1483-1494. doi: 10.1080/09553002.2023.2188935. 
      Epub 2023 Mar 23.