PMID- 36912948
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230411
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Linking)
VI  - 241
IP  - 4
DP  - 2023 Apr
TI  - Acute bouts of aerobic and resistance exercise similarly alter inhibitory control 
      and response time while inversely modifying plasma BDNF concentrations in 
      middle-aged and older adults with type 2 diabetes.
PG  - 1173-1183
LID - 10.1007/s00221-023-06588-8 [doi]
AB  - Impairments in several domains of cognitive functions are observed in people with 
      Type 2 Diabetes Mellitus (T2DM), often accompanied by low Brain-derived 
      neurotrophic factor (BDNF) concentrations. Although aerobic and resistance 
      exercise enhances cognitive functions and raises BDNF concentrations in several 
      populations, it remained uncertain in T2DM subjects. This study compared the 
      effects of a single bout of aerobic (AER, 40 min of treadmill walk at 90-95% of 
      the maximum walk speed) or resistance (RES, 3 x 10 repetitions in eight exercises 
      at 70% of 10-RM) exercise on specific cognitive domain performance and plasma 
      BDNF concentrations of physically active T2DM subjects. Eleven T2DM subjects (9 
      women/2 men; 63 +/- 7 years) performed two counterbalanced trials on 
      non-consecutive days. Stroop Color and Word (SCW) task [assessing the attention 
      (congruent condition) and inhibitory control (incongruent condition)], Visual 
      response time (assessing the response time), and blood collection (for plasma 
      BDNF concentrations) were performed pre and post-exercise sessions. With distinct 
      magnitude, both AER and RES improved the incongruent-SCW (d = - 0.26 vs. - 0.43 
      in AER and RES, respectively; p < 0.05), RT((best)) (d = - 0.31 vs. - 0.52, 
      p < 0.05), and RT((1-5)) (d = - 0.64 vs. - 0.21, p < 0.05). The congruent-SCW and 
      RT((6-10)) were not statistically different. Plasma BDNF concentrations were 
      elevated 11% in AER (d = 0.30) but decreased by 15% in RES (d = - 0.43). A single 
      session of aerobic or resistance exercise similarly improved the inhibitory 
      control and response time of physically active T2DM subjects. Nevertheless, 
      aerobic and resistance exercise sessions induced an opposite clinical effect in 
      plasma BDNF concentrations.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Silveira-Rodrigues, Joao G
AU  - Silveira-Rodrigues JG
AUID- ORCID: 0000-0003-2646-5079
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil.
AD  - Movement Laboratory, Medicine School, Federal University of Minas Gerais, Belo 
      Horizonte, MG, 31270-901, Brazil.
FAU - Campos, Bruno T
AU  - Campos BT
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil.
FAU - de Lima, Andre T
AU  - de Lima AT
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil.
FAU - Ogando, Pedro H M
AU  - Ogando PHM
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil.
AD  - Movement Laboratory, Medicine School, Federal University of Minas Gerais, Belo 
      Horizonte, MG, 31270-901, Brazil.
FAU - Gomes, Camila B
AU  - Gomes CB
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil.
FAU - Gomes, Patricia F
AU  - Gomes PF
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil.
FAU - Aleixo, Ivana M S
AU  - Aleixo IMS
AD  - Movement Laboratory, Medicine School, Federal University of Minas Gerais, Belo 
      Horizonte, MG, 31270-901, Brazil.
FAU - Soares, Danusa D
AU  - Soares DD
AD  - Exercise Physiology Laboratory, School of Physical Education, Physiotherapy and 
      Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, MG, 
      31270-901, Brazil. danusa56@gmail.com.
LA  - eng
GR  - APQ-00417-15/Fundacao de Amparo a Pesquisa do Estado de Minas Gerais/
GR  - APQ 0354615/Fundacao de Amparo a Pesquisa do Estado de Minas Gerais/
PT  - Journal Article
DEP - 20230313
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Male
MH  - Middle Aged
MH  - Humans
MH  - Female
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Brain-Derived Neurotrophic Factor
MH  - *Resistance Training
MH  - Reaction Time
MH  - Exercise/physiology
OTO - NOTNLM
OT  - Cardiovascular exercise
OT  - Cognition
OT  - Cognitive impairment
OT  - Metabolic disease
OT  - Strength exercise
EDAT- 2023/03/14 06:00
MHDA- 2023/04/11 06:41
CRDT- 2023/03/13 12:14
PHST- 2022/09/22 00:00 [received]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/04/11 06:41 [medline]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/13 12:14 [entrez]
AID - 10.1007/s00221-023-06588-8 [pii]
AID - 10.1007/s00221-023-06588-8 [doi]
PST - ppublish
SO  - Exp Brain Res. 2023 Apr;241(4):1173-1183. doi: 10.1007/s00221-023-06588-8. Epub 
      2023 Mar 13.