PMID- 36913660
OWN - NLM
STAT- MEDLINE
DCOM- 20230315
LR  - 20230315
IS  - 2159-3000 (Print)
IS  - 2159-3000 (Linking)
VI  - 526
DP  - 2023 Mar
TI  - Autoimmune Skin Conditions: Cutaneous Lupus Erythematosus.
PG  - 25-36
AB  - Cutaneous lupus erythematosus (CLE) is a spectrum of autoimmune skin conditions 
      associated with systemic lupus erythematosus (SLE). CLE and SLE may exist 
      concurrently or independently. Accurate recognition of CLE is crucial because it 
      may herald systemic disease onset. Lupus-specific skin conditions include acute 
      cutaneous lupus erythematosus (ACLE) which manifests as a malar or butterfly 
      rash; subacute cutaneous lupus erythematosus (SCLE); and chronic cutaneous lupus 
      erythematosus, which includes discoid lupus erythematosus (DLE). All three types 
      of CLE present as pink-violet macules or plaques with unique morphology, in areas 
      of sun-exposed skin. Association with SLE differs: ACLE is most closely 
      associated, with SCLE in the middle, and DLE the least so. All types of CLE are 
      pruritic, sting, and burn, and DLE can result in disfiguring scarring. All CLE is 
      exacerbated by UV light exposure and smoking. Diagnosis combines clinical 
      evaluation with skin biopsy. Management focuses on mitigating modifiable risk 
      factors and using pharmacotherapy. UV protection includes use of sun protective 
      factor (SPF) 60 or higher sunscreens containing zinc oxide or titanium dioxide, 
      avoidance of sun exposure, and use of physical barrier clothing. Topical 
      therapies and antimalarial drugs are first-line, followed by systemic therapies 
      (eg, disease-modifying antirheumatic drugs, biologic therapies [eg, anifrolumab, 
      belimumab], or other advanced systemic drugs).
FAU - Foulke, Galen
AU  - Foulke G
AD  - Department of Dermatology - Penn State College of Medicine, 700 HMC Crescent 
      Road, Hershey, PA 17033.
FAU - Helm, Leesha A
AU  - Helm LA
AD  - Department of Family and Community Medicine - Penn State College of Medicine, 700 
      HMC Crescent Road, Hershey, PA 17033.
FAU - Clebak, Karl T
AU  - Clebak KT
AD  - Department of Family and Community Medicine - Penn State College of Medicine, 700 
      HMC Crescent Road, Hershey, PA 17033.
FAU - Helm, Matthew
AU  - Helm M
AD  - Department of Dermatology - Penn State College of Medicine, 700 HMC Crescent 
      Road, Hershey, PA 17033.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - FP Essent
JT  - FP essentials
JID - 101578821
RN  - 0 (Antirheumatic Agents)
RN  - malar rash
SB  - IM
MH  - Humans
MH  - *Lupus Erythematosus, Cutaneous/therapy/drug therapy
MH  - *Lupus Erythematosus, Discoid/therapy/drug therapy
MH  - *Lupus Erythematosus, Systemic/drug therapy
MH  - *Antirheumatic Agents/therapeutic use
MH  - Acute Disease
MH  - Skin/pathology
EDAT- 2023/03/14 06:00
MHDA- 2023/03/16 06:00
CRDT- 2023/03/13 16:13
PHST- 2023/03/13 16:13 [entrez]
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/16 06:00 [medline]
PST - ppublish
SO  - FP Essent. 2023 Mar;526:25-36.