PMID- 36913722
OWN - NLM
STAT- MEDLINE
DCOM- 20230324
LR  - 20230404
IS  - 1520-4804 (Electronic)
IS  - 0022-2623 (Linking)
VI  - 66
IP  - 6
DP  - 2023 Mar 23
TI  - ESIPT-, AIE-, and AIE + ESIPT-Based Light-Activated Drug Delivery Systems and 
      Bioactive Donors for Targeted Disease Treatment.
PG  - 3732-3745
LID - 10.1021/acs.jmedchem.2c01466 [doi]
AB  - Targeted release of bioactive molecules for therapeutic purposes is a key area in 
      the biomedical field that is growing quickly, where bioactive molecules are 
      released passively or actively from drug delivery systems (DDSs) or bioactive 
      donors. In the past decade, researchers have identified light as one of the prime 
      stimuli that can implement the efficient spatiotemporally targeted delivery of 
      drugs or gaseous molecules with minimal cytotoxicity and a real-time monitoring 
      ability. This perspective emphasizes recent advances in the photophysical 
      properties of ESIPT- (excited-state intramolecular proton transfer), AIE- 
      (aggregation-induced emission), and AIE + ESIPT-attributed light-activated 
      delivery systems or donors. The three major sections of this perspective describe 
      the distinctive features of DDSs and donors concerning their design, synthesis, 
      photophysical and photochemical properties, and in vitro and in vivo studies 
      demonstrating their relevance as carrier molecules for releasing cancer drugs and 
      gaseous molecules in the biological system.
FAU - Singh, Amit Kumar
AU  - Singh AK
AD  - Department of Chemistry, Photochemistry Laboratory, Indian Institute of 
      Technology Kharagpur, Kharagpur, West Bengal 721302, India.
FAU - Nair, Asha V
AU  - Nair AV
AD  - Department of Chemistry, Photochemistry Laboratory, Indian Institute of 
      Technology Kharagpur, Kharagpur, West Bengal 721302, India.
FAU - Shah, Sk Sheriff
AU  - Shah SS
AD  - Department of Chemistry, Photochemistry Laboratory, Indian Institute of 
      Technology Kharagpur, Kharagpur, West Bengal 721302, India.
FAU - Ray, Souvik
AU  - Ray S
AD  - Department of Chemistry, Photochemistry Laboratory, Indian Institute of 
      Technology Kharagpur, Kharagpur, West Bengal 721302, India.
FAU - Singh, N D Pradeep
AU  - Singh NDP
AUID- ORCID: 0000-0001-6806-9774
AD  - Department of Chemistry, Photochemistry Laboratory, Indian Institute of 
      Technology Kharagpur, Kharagpur, West Bengal 721302, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230313
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protons)
SB  - IM
MH  - *Drug Delivery Systems
MH  - *Antineoplastic Agents/pharmacology
MH  - Protons
EDAT- 2023/03/14 06:00
MHDA- 2023/03/25 06:00
CRDT- 2023/03/13 18:12
PHST- 2023/03/14 06:00 [pubmed]
PHST- 2023/03/25 06:00 [medline]
PHST- 2023/03/13 18:12 [entrez]
AID - 10.1021/acs.jmedchem.2c01466 [doi]
PST - ppublish
SO  - J Med Chem. 2023 Mar 23;66(6):3732-3745. doi: 10.1021/acs.jmedchem.2c01466. Epub 
      2023 Mar 13.