PMID- 36915733
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230315
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 15
IP  - 2
DP  - 2023
TI  - Effect of acupuncture at Xinwu acupoint combined with loratadine and fluticasone 
      propionate on symptom alleviation, nasal function, and serum histamine level in 
      patients with allergic rhinitis.
PG  - 1403-1411
AB  - OBJECTIVE: To determine the influence of acupuncture at the Xinwu acupoint 
      combined with western medicine (loratadine and fluticasone propionate) on symptom 
      alleviation, nasal mucociliary clearance velocity (MCV), and serum histamine 
      level of patients with allergic rhinitis (AR). METHODS: A total of 122 patients 
      with AR treated in Gansu province hospital of TCM and The Third People's Hospital 
      of Gansu Province from April 2019 to April 2021 were retrospectively analyzed. 
      Among them, 54 patients treated with loratadine and fluticasone propionate were 
      assigned to the control group, and 68 patients treated with additional 
      acupuncture at the Xinwu acupoint based on treatment of the control group were 
      assigned to the observation group. The treatment efficacy of the two groups was 
      compared, and the scores of main symptoms and nasal function were also compared 
      before and after therapy. Additionally, the two groups were compared in the 
      levels of histamine, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and 
      immunoglobulin E (IgE) before and after therapy. RESULTS: After therapy, the 
      observation group yielded a higher total effective rate than the control group 
      (P=0.006) and had lower symptom scores than the control group (P<0.001). 
      Additionally, the MCV of the two groups increased (P<0.001), and the nasal 
      mucociliary transit time (MTT) and nasal resistance (NR) of both groups decreased 
      (P<0.001) after therapy. The observation group showed a greatly better 
      improvement of nasal function than the control group (P<0.001). Moreover, after 
      therapy, the observation group showed lower histamine and IgE levels than the 
      control group (P<0.01) and the observation group presented significantly lower 
      levels than the control group, and had lower rhinoconjunctivitis Quality of Life 
      Questionnaire (RQLQ) scores than the control group (P<0.001). The two groups were 
      not different in the incidence of adverse reactions (P=0.886). CONCLUSION: 
      Acupuncture at Xinwu acupoint combined with loratadine and fluticasone propionate 
      can deliver a powerful efficacy on AR and alleviate the clinical symptoms, 
      without increasing adverse reactions.
CI  - AJTR Copyright (c) 2023.
FAU - Wang, Zhongxia
AU  - Wang Z
AD  - Otolaryngology Department, Gansu Province Hospital of TCM No. 418, Guazhou Road, 
      Qilihe District, Lanzhou 730050, Gansu, China.
FAU - Wang, Zhiyong
AU  - Wang Z
AD  - Medical Services Section, Gansu Province Hospital of TCM No. 418, Guazhou Road, 
      Qilihe District, Lanzhou 730050, Gansu, China.
FAU - Jiang, Yan
AU  - Jiang Y
AD  - Otolaryngology Department, Gansu Province Hospital of TCM No. 418, Guazhou Road, 
      Qilihe District, Lanzhou 730050, Gansu, China.
FAU - Li, Jinhua
AU  - Li J
AD  - Traditional Chinese Medicine Department, Gansu Provincial People's Hospital No. 
      204, Donggang West Road, Chengguan District, Lanzhou 730000, Gansu, China.
FAU - Wu, Xiaoyan
AU  - Wu X
AD  - Traditional Chinese Medicine Department, Longxi County Traditional Chinese 
      Medicine Inheritance and Innovation Demonstration Center Dingxi, Gansu, China.
FAU - Wu, Jianxin
AU  - Wu J
AD  - Traditional Chinese Medicine Department, The Third People's Hospital of Gansu 
      Province No. 763, Jiatan, Chengguan District, Lanzhou 730000, Gansu, China.
LA  - eng
PT  - Journal Article
DEP - 20230215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC10006795
OTO - NOTNLM
OT  - Acupuncture
OT  - Xinwu acupoint
OT  - allergic rhinitis
OT  - fluticasone propionate
OT  - histamine
OT  - loratadine
OT  - nasal function
COIS- None.
EDAT- 2023/03/15 06:00
MHDA- 2023/03/15 06:01
PMCR- 2023/02/15
CRDT- 2023/03/14 02:11
PHST- 2022/11/24 00:00 [received]
PHST- 2023/01/11 00:00 [accepted]
PHST- 2023/03/14 02:11 [entrez]
PHST- 2023/03/15 06:00 [pubmed]
PHST- 2023/03/15 06:01 [medline]
PHST- 2023/02/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2023 Feb 15;15(2):1403-1411. eCollection 2023.