PMID- 36915817
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240325
IS  - 2227-684X (Print)
IS  - 2227-8575 (Electronic)
IS  - 2227-684X (Linking)
VI  - 12
IP  - 2
DP  - 2023 Feb 28
TI  - Development of a basement membrane gene signature and identification of the 
      potential candidate therapeutic targets for pancreatic cancer.
PG  - 263-281
LID - 10.21037/gs-23-24 [doi]
AB  - BACKGROUND: Pancreatic cancer is a deadly cancer with a poor prognosis. In light 
      of mounting evidence that basement membrane genes (BMGs) play a role in the 
      development of cancer, we sought to examine the prognostic importance and role of 
      BMGs in pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: BMGs were 
      obtained from previous top research studies. The clinical and messenger 
      ribonucleic acid expression data were retrieved from the Gene Expression Omnibus 
      (GEO) and The Cancer Genome Atlas (TCGA) data sets, respectively. Cox regression 
      and least absolute shrinkage and selection operator (LASSO) regression analyses 
      were used for the PDAC risk modeling and gene identification. The Kaplan-Meier 
      method was used to compare outcomes between the low- and high-risk groups. 
      Finally, we analyzed small-molecule drugs that could be used to target BMGs for 
      treatment using the Enrichr data set and validated the function of the 
      tubulointerstitial nephritis antigen (TINAG) in pancreatic cancer. RESULTS: We 
      successfully constructed and validated a 7 BMG-based model to predict PDAC 
      patient outcomes. Additionally, we discovered that 7 BMG-based model was an 
      independent predictive factor for PDAC. According to our functional analysis, the 
      majority of the signaling pathways enriched in BMGs were those connected to 
      malignancy. Immune cell infiltration and immunological checkpoints were also 
      linked to the BMG-based model. Further, we identified 5 small-molecule drugs that 
      may be useful in treating PDAC patients. We also found that TINAG promoted cell 
      proliferation in pancreatic cancer. CONCLUSIONS: Our study extended 
      understandings of how BMGs work in PDAC. We identified a credible predictive 
      biomarker for PDAC patients' survival.
CI  - 2023 Gland Surgery. All rights reserved.
FAU - Lin, Kai
AU  - Lin K
AD  - Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 
      Nanjing, China.
AD  - Department of Gastrointestinal Surgery, Affiliated Hangzhou First People's 
      Hospital, Zhejiang University School of Medicine, Hangzhou, China.
FAU - Xu, Dong
AU  - Xu D
AD  - Department of General Surgery, Gaochun People's Hospital, Nanjing, China.
FAU - Wang, Xiaoxiao
AU  - Wang X
AD  - Department of GCP Research Center, The Affiliated Hospital of Nanjing University 
      of Chinese Medicine, Nanjing, China.
FAU - Shi, Jun
AU  - Shi J
AD  - School of Traditional Chinese Medicine and School of Integrated Chinese and 
      Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
FAU - Gao, Wentao
AU  - Gao W
AD  - Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20230227
PL  - China (Republic : 1949- )
TA  - Gland Surg
JT  - Gland surgery
JID - 101606638
PMC - PMC10005979
OTO - NOTNLM
OT  - Basement membrane (BM)
OT  - gene signature
OT  - pancreatic cancer
OT  - prediction
OT  - prognosis
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at https://gs.amegroups.com/article/view/10.21037/gs-23-24/coif). 
      The authors have no conflicts of interest to declare.
EDAT- 2023/03/15 06:00
MHDA- 2023/03/15 06:01
PMCR- 2023/02/28
CRDT- 2023/03/14 02:12
PHST- 2022/12/21 00:00 [received]
PHST- 2023/02/10 00:00 [accepted]
PHST- 2023/03/14 02:12 [entrez]
PHST- 2023/03/15 06:00 [pubmed]
PHST- 2023/03/15 06:01 [medline]
PHST- 2023/02/28 00:00 [pmc-release]
AID - gs-12-02-263 [pii]
AID - 10.21037/gs-23-24 [doi]
PST - ppublish
SO  - Gland Surg. 2023 Feb 28;12(2):263-281. doi: 10.21037/gs-23-24. Epub 2023 Feb 27.