PMID- 36916703
OWN - NLM
STAT- MEDLINE
DCOM- 20230407
LR  - 20230407
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 15
IP  - 14
DP  - 2023 Apr 6
TI  - Biomimetic nanoparticles for DC vaccination: a versatile approach to boost cancer 
      immunotherapy.
PG  - 6432-6455
LID - 10.1039/d2nr07071e [doi]
AB  - Cancer immunotherapy, which harnesses the immune system to fight cancer, has 
      begun to make a breakthrough in clinical applications. Dendritic cells (DCs) are 
      the bridge linking innate and adaptive immunity and the trigger of tumor immune 
      response. Considering the cumbersome process and poor efficacy of classic DC 
      vaccines, there has been interest in transferring the field of in vitro-generated 
      DC vaccines to nanovaccines. Conventional nanoparticles have insufficient 
      targeting ability and are easily cleared by the reticuloendothelial system. 
      Biological components have evolved very specific functions, which are difficult 
      to fully reproduce with synthetic materials, making people interested in using 
      the further understanding of biological systems to prepare nanoparticles with new 
      and enhanced functions. Biomimetic nanoparticles are semi-biological or 
      nature-derived delivery systems comprising one or more natural materials, which 
      have a long circulation time in vivo and excellent performance of targeting DCs, 
      and can mimic the antigen-presenting behavior of DCs. In this review, we 
      introduce the classification, design, preparation, and challenges of different 
      biomimetic nanoparticles, and discuss their application in activating DCs in vivo 
      and stimulating T cell antitumor immunity. Incorporating biomimetic nanoparticles 
      into cancer immunotherapy has shown outstanding advantages in precisely coaxing 
      the immune system against cancer.
FAU - Meng, Lingyang
AU  - Meng L
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
FAU - Teng, Zhuang
AU  - Teng Z
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
FAU - Yang, Shuang
AU  - Yang S
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
FAU - Wang, Na
AU  - Wang N
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
FAU - Guan, YingHua
AU  - Guan Y
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
FAU - Chen, Xiguang
AU  - Chen X
AUID- ORCID: 0000-0001-5802-5364
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
AD  - Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266000, 
      P.R. China.
FAU - Liu, Ya
AU  - Liu Y
AUID- ORCID: 0000-0002-0750-4979
AD  - College of Marine Life Science, Ocean University of China, Qingdao, 266003, P.R. 
      China. yaliu@ouc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230406
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Cancer Vaccines)
SB  - IM
MH  - Humans
MH  - Dendritic Cells
MH  - Biomimetics
MH  - *Neoplasms/drug therapy
MH  - Immunotherapy
MH  - Vaccination
MH  - *Nanoparticles
MH  - *Cancer Vaccines
EDAT- 2023/03/15 06:00
MHDA- 2023/04/07 06:41
CRDT- 2023/03/14 08:13
PHST- 2023/04/07 06:41 [medline]
PHST- 2023/03/15 06:00 [pubmed]
PHST- 2023/03/14 08:13 [entrez]
AID - 10.1039/d2nr07071e [doi]
PST - epublish
SO  - Nanoscale. 2023 Apr 6;15(14):6432-6455. doi: 10.1039/d2nr07071e.