PMID- 36917312
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231026
IS  - 2629-3277 (Electronic)
IS  - 2629-3277 (Linking)
VI  - 19
IP  - 5
DP  - 2023 Jul
TI  - Research Progress on the Osteogenesis-Related Regulatory Mechanisms of Human 
      Umbilical Cord Mesenchymal Stem Cells.
PG  - 1252-1267
LID - 10.1007/s12015-023-10521-5 [doi]
AB  - In recent years, research on human umbilical cord mesenchymal stem cells 
      (hUCMSCs) derived from human umbilical cord tissue has accelerated and entered 
      clinical application research. Compared with mesenchymal stem cells (MSCs) from 
      other sources, hUCMSCs can be extracted from different parts of umbilical cord or 
      from the whole umbilical cord. It has the characteristics of less ethical 
      controversy, high differentiation potential, strong proliferation ability, 
      efficient expansion in vitro, avoiding immune rejection and immune privilege, and 
      avoids the limitations of lack of embryonic stem cells, heterogeneity, ethical 
      and moral constraints. hUCMSCs avoid the need for embryonic stem cell sources, 
      heterogeneity, and ethical and moral constraints. Bone defects are very common in 
      clinical practice, but completely effective bone tissue regeneration treatment is 
      challenging. Currently, autologous bone transplantation and allogeneic bone 
      transplantation are main treatment approaches in clinical work, but each has 
      different shortcomings, such as limited sources, invasiveness, immune rejection 
      and insufficient osteogenic ability. Therefore, to solve the bottleneck of bone 
      tissue regeneration and repair, a great amount of research has been carried out 
      to explore the clinical advantages of hUCMSCs as seed cells to promote 
      osteogenesis.However, the regulation of osteogenic differentiation of hUCMSCs is 
      an extremely complex process. Although a large number of studies have 
      demonstrated that the role of hUCMSCs in enhancing local bone regeneration and 
      repair through osteogenic differentiation and transplantation into the body 
      involves multiple signaling pathways, there is no relevant article that summarize 
      the findings. This article discusses the osteogenesis-related regulatory 
      mechanisms of hUCMSCs, summarizes the currently known related mechanisms, and 
      speculates on the possible signals.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Hu, Zhengqi
AU  - Hu Z
AUID- ORCID: 0000-0003-0246-272X
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi, 563000, Guizhou, China.
FAU - Jiang, Zhiliang
AU  - Jiang Z
AUID- ORCID: 0000-0001-9861-7815
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi, 563000, Guizhou, China.
FAU - Meng, Shengzi
AU  - Meng S
AUID- ORCID: 0000-0003-1727-254X
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi, 563000, Guizhou, China.
FAU - Liu, Rong
AU  - Liu R
AUID- ORCID: 0000-0002-6316-3160
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi, 563000, Guizhou, China.
FAU - Yang, Kun
AU  - Yang K
AUID- ORCID: 0000-0002-7720-8681
AD  - Department of Periodontology, Hospital of Stomatology, Zunyi Medical University, 
      Zunyi, 563000, Guizhou, China. Yookun@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230314
PL  - United States
TA  - Stem Cell Rev Rep
JT  - Stem cell reviews and reports
JID - 101752767
SB  - IM
MH  - Humans
MH  - *Osteogenesis/physiology
MH  - Bone Regeneration
MH  - Bone and Bones
MH  - *Mesenchymal Stem Cells
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Molecular mechanism
OT  - OC differentiation
OT  - Regeneration and repair
OT  - Signaling pathway
OT  - Tissue engineering
OT  - hUCMSCs
EDAT- 2023/03/15 06:00
MHDA- 2023/10/23 12:42
CRDT- 2023/03/14 12:16
PHST- 2023/02/19 00:00 [accepted]
PHST- 2023/10/23 12:42 [medline]
PHST- 2023/03/15 06:00 [pubmed]
PHST- 2023/03/14 12:16 [entrez]
AID - 10.1007/s12015-023-10521-5 [pii]
AID - 10.1007/s12015-023-10521-5 [doi]
PST - ppublish
SO  - Stem Cell Rev Rep. 2023 Jul;19(5):1252-1267. doi: 10.1007/s12015-023-10521-5. 
      Epub 2023 Mar 14.