PMID- 36917442
OWN - NLM
STAT- MEDLINE
DCOM- 20231023
LR  - 20231107
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 27
IP  - 5
DP  - 2023 Oct
TI  - Upregulation of peripheral blood mononuclear cells resistin gene expression in 
      severe obstructive sleep apnea and obstructive sleep apnea with coexisting type 2 
      diabetes mellitus.
PG  - 2031-2039
LID - 10.1007/s11325-023-02809-0 [doi]
AB  - PURPOSE: Obstructive sleep apnea (OSA) is characterised by increased systemic 
      inflammation, and is often accompanied with type 2 diabetes mellitus (T2DM) and 
      cardiovascular disease. The aim of this investigation was to evaluate gene 
      expression of resistin, its receptor CAP1 and CD36 as the indicators of the 
      inflammatory changes in PBMCs in relation to the severity of OSA, and the 
      presence of type 2 diabetes mellitus (T2DM) in OSA. METHODS: Severity of OSA was 
      defined by the apnea/hypopnea index (AHI): AHI < 30: mild to moderate OSA 
      (MM-OSA), AHI >/= 30: severe OSA (S-OSA). Presence of T2DM was captured: OSA with 
      T2DM (OSA + T2DM), OSA without T2DM (OSA-T2DM). PBMC resistin, CAP1, and CD36 
      mRNA were determined by real-time PCR. RESULTS: Resistin mRNA was significantly 
      upregulated in S-OSA (N = 54) compared to the MM-OSA (N = 52, P = 0.043); CAP1 
      and CD36 mRNA levels did not differ between the groups (P = 0.302; P = 0.166, 
      respectively). Resistin mRNA was significantly upregulated in OSA + T2DM (N = 
      29) compared to the OSA-T2DM (N = 77, P = 0.029); CAP1 and CD36 mRNA levels did 
      not differ between the groups (P = 0.662; P = 0.108, respectively). AHI and T2DM 
      were independent predictors of resistin mRNA above the 75th percentile 
      (OR = 3.717 [1.152-11.991]; OR = 3.261 [1.000-10.630], P = 0.042 respectively). 
      CONCLUSION: Resistin gene upregulation in S-OSA indicates its possible 
      contribution to increased inflammation in S-OSA and makes it a possible marker of 
      the disease severity. Resistin gene upregulation in OSA + T2DM suggests that 
      a joint effect of these two comorbidities may have a major contribution to 
      increased inflammation and complications that arise from this state.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Rajkov, Branislava
AU  - Rajkov B
AD  - Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, 
      Belgrade, Serbia.
FAU - Zdravkovic, Marija
AU  - Zdravkovic M
AD  - Department of Cardiology, University Medical Center "Bezanijska Kosa", Belgrade, 
      Serbia.
AD  - Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
FAU - Ninic, Ana
AU  - Ninic A
AUID- ORCID: 0000-0003-3838-1606
AD  - Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, 
      Belgrade, Serbia. aninic@pharmacy.bg.ac.rs.
FAU - Brajkovic, Milica
AU  - Brajkovic M
AD  - Department of Pulmology, University Medical Center "Bezanijska Kosa", Belgrade, 
      Serbia.
FAU - Klasnja, Slobodan
AU  - Klasnja S
AD  - Department of Cardiology, University Medical Center "Bezanijska Kosa", Belgrade, 
      Serbia.
FAU - Gardijan, Vera
AU  - Gardijan V
AD  - Department of Pulmology, University Medical Center "Bezanijska Kosa", Belgrade, 
      Serbia.
FAU - Memon, Lidija
AU  - Memon L
AD  - Department of Laboratory Diagnostics, University Medical Center "Bezanijska 
      Kosa", Belgrade, Serbia.
FAU - Munjas, Jelena
AU  - Munjas J
AUID- ORCID: 0000-0002-4576-1722
AD  - Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, 
      Belgrade, Serbia. jelenaj@pharmacy.bg.ac.rs.
FAU - Mihajlovic, Marija
AU  - Mihajlovic M
AD  - Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, 
      Belgrade, Serbia.
FAU - Spasojevic-Kalimanovska, Vesna
AU  - Spasojevic-Kalimanovska V
AD  - Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, 
      Belgrade, Serbia.
FAU - Radosavljevic, Vojislav
AU  - Radosavljevic V
AD  - Department of Pulmology, University Medical Center "Bezanijska Kosa", Belgrade, 
      Serbia.
FAU - Sopic, Miron
AU  - Sopic M
AUID- ORCID: 0000-0003-3283-9487
AD  - Department of Medical Biochemistry, University of Belgrade - Faculty of Pharmacy, 
      Belgrade, Serbia. miron.sopic@pharmacy.bg.ac.rs.
LA  - eng
GR  - 175035/Ministarstvo Prosvete, Nauke i Tehnoloskog Razvoja/
PT  - Journal Article
DEP - 20230314
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - 0 (Resistin)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - Leukocytes, Mononuclear
MH  - Up-Regulation/genetics
MH  - Resistin/genetics
MH  - Inflammation/complications
MH  - *Sleep Apnea, Obstructive/complications
MH  - RNA, Messenger
MH  - Gene Expression/genetics
OTO - NOTNLM
OT  - CAP1
OT  - CD36
OT  - Obstructive sleep apnea
OT  - Resistin
EDAT- 2023/03/15 06:00
MHDA- 2023/10/23 12:44
CRDT- 2023/03/14 12:22
PHST- 2021/12/14 00:00 [received]
PHST- 2023/03/06 00:00 [accepted]
PHST- 2023/02/27 00:00 [revised]
PHST- 2023/10/23 12:44 [medline]
PHST- 2023/03/15 06:00 [pubmed]
PHST- 2023/03/14 12:22 [entrez]
AID - 10.1007/s11325-023-02809-0 [pii]
AID - 10.1007/s11325-023-02809-0 [doi]
PST - ppublish
SO  - Sleep Breath. 2023 Oct;27(5):2031-2039. doi: 10.1007/s11325-023-02809-0. Epub 
      2023 Mar 14.