PMID- 36920345
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20230328
LR  - 20230328
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 95
IP  - 12
DP  - 2023 Mar 28
TI  - (1)O(2)-Relevant Afterglow Luminescence of Chlorin Nanoparticles for 
      Discriminative Detection and Isotopic Analysis of H(2)O and D(2)O.
PG  - 5340-5345
LID - 10.1021/acs.analchem.2c05459 [doi]
AB  - Discriminative detection between D(2)O and H(2)O is important for diverse fields 
      but challenging due to their high similarity in chemical and physical properties. 
      Current molecular sensors for D(2)O detection generally rely on the spectral 
      change of fluorophores with suitable pK(a) in response to D(2)O and H(2)O with 
      slightly different pH acidity. Herein, we report a new and facile D(2)O sensor by 
      using singlet oxygen ((1)O(2))-relevant afterglow luminescence of chlorin e4 
      nanoparticles (Ce4-NPs) to achieve distinguishable detection between D(2)O and 
      H(2)O. As (1)O(2) is a key initiator involved in the afterglow luminescence 
      process, it displays a 22-fold longer lifetime in D(2)O relative to H(2)O and 
      thereafter generates more dioxetane intermediates after laser irradiation to lead 
      to ultimate afterglow brightness of Ce4-NPs in D(2)O. In addition, Ce4-NPs are 
      capable of quantitatively detecting the amount of H(2)O in D(2)O with a limit of 
      detection (LOD) of 1.45%. Together, this study broadens the utility of afterglow 
      materials and presents a facile strategy for isotopic purity analysis of heavy 
      water.
FAU - Chen, Wan
AU  - Chen W
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
FAU - Jiang, Yue
AU  - Jiang Y
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
FAU - Zhao, Min
AU  - Zhao M
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
FAU - An, Yi
AU  - An Y
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
FAU - Yang, Li
AU  - Yang L
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
FAU - Miao, Qingqing
AU  - Miao Q
AUID- ORCID: 0000-0001-8973-6687
AD  - State Key Laboratory of Radiation Medicine and Protection, School for 
      Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation 
      Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow 
      University, Suzhou 215123, China.
AD  - School of Nuclear Science and Technology, University of Science and Technology of 
      China, Hefei 230026, China.
LA  - eng
PT  - Journal Article
DEP - 20230315
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
SB  - IM
EDAT- 2023/03/16 06:00
MHDA- 2023/03/16 06:01
CRDT- 2023/03/15 11:22
PHST- 2023/03/16 06:01 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 11:22 [entrez]
AID - 10.1021/acs.analchem.2c05459 [doi]
PST - ppublish
SO  - Anal Chem. 2023 Mar 28;95(12):5340-5345. doi: 10.1021/acs.analchem.2c05459. Epub 
      2023 Mar 15.