PMID- 36920535
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240312
IS  - 1433-8491 (Electronic)
IS  - 0940-1334 (Print)
IS  - 0940-1334 (Linking)
VI  - 273
IP  - 8
DP  - 2023 Dec
TI  - Attentional biases in facial emotion processing in individuals at clinical high 
      risk for psychosis.
PG  - 1825-1835
LID - 10.1007/s00406-023-01582-1 [doi]
AB  - Individuals at clinical high risk (CHR) for psychosis exhibit altered facial 
      emotion processing (FEP) and poor social functioning. It is unclear whether FEP 
      deficits result from attentional biases, and further, how these abnormalities are 
      linked to symptomatology (e.g., negative symptoms) and highly comorbid disorders 
      that are also tied to abnormal FEP (e.g., depression). In the present study, we 
      employed an eye-tracking paradigm to assess attentional biases and clinical 
      interviews to examine differences between CHR (N = 34) individuals and healthy 
      controls (HC; N = 46), as well as how such biases relate to symptoms and 
      functioning in CHR individuals. Although no CHR-HC differences emerged in 
      attentional biases, within the CHR group, symptoms and functioning were related 
      to biases. Depressive symptoms were related to some free-view attention switching 
      biases (e.g., to and from fearful faces, r = .50). Negative symptoms were related 
      to more slowly disengaging from happy faces (r = .44), spending less time looking 
      at neutral faces (r =  - .42), and more time looking at no face (Avolition, 
      r = .44). In addition, global social functioning was related to processes that 
      overlapped with both depression and negative symptoms, including time looking at 
      no face (r =  - .68) and free-view attention switching with fearful faces 
      (r =  - .40). These findings are consistent with previous research, indicating 
      that negative symptoms play a prominent role in the CHR syndrome, with distinct 
      mechanisms relative to depression. Furthermore, the results suggest that 
      attentional bias indices from eye-tracking paradigms may be predictive of social 
      functioning.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
FAU - Williams, Trevor F
AU  - Williams TF
AUID- ORCID: 0000-0003-2202-7020
AD  - Department of Psychology, Northwestern University, Evanston, IL, 60208, USA. 
      trevor.williams@northwestern.edu.
FAU - Cohen, Alex S
AU  - Cohen AS
AD  - Department of Psychology, Louisiana State University, Baton Rouge, LA, 70803, 
      USA.
FAU - Sanchez-Lopez, Alvaro
AU  - Sanchez-Lopez A
AD  - Department of Clinical Psychology, Complutense University of Madrid, Madrid, 
      28223, Spain.
FAU - Joormann, Jutta
AU  - Joormann J
AD  - Department of Psychology, Yale University, New Haven, CT, 06520, USA.
FAU - Mittal, Vijay A
AU  - Mittal VA
AD  - Department of Psychology, Northwestern University, Evanston, IL, 60208, USA.
LA  - eng
GR  - R21 MH110374/MH/NIMH NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R21/R33MH103231/MH/NIMH NIH HHS/United States
GR  - R01MH112545-01/MH/NIMH NIH HHS/United States
GR  - R21 MH103231/MH/NIMH NIH HHS/United States
GR  - R21MH110374/MH/NIMH NIH HHS/United States
GR  - R01 MH112545/MH/NIMH NIH HHS/United States
GR  - R21 MH119677/MH/NIMH NIH HHS/United States
GR  - R21MH119677/MH/NIMH NIH HHS/United States
GR  - R21MH115231/MH/NIMH NIH HHS/United States
GR  - R33 MH103231/MH/NIMH NIH HHS/United States
GR  - R21 MH115231/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20230315
PL  - Germany
TA  - Eur Arch Psychiatry Clin Neurosci
JT  - European archives of psychiatry and clinical neuroscience
JID - 9103030
SB  - IM
MH  - Humans
MH  - *Attentional Bias
MH  - Emotions
MH  - Attention
MH  - Fear
MH  - *Psychotic Disorders/complications
MH  - Facial Expression
PMC - PMC10502185
MID - NIHMS1907818
OTO - NOTNLM
OT  - Attentional bias
OT  - Clinical high risk
OT  - Eye tracking
OT  - Social functioning
COIS- Conflicts of Interest The authors declare that they have no conflict of interest, 
      financial or non-financial.
EDAT- 2023/03/16 06:00
MHDA- 2023/12/17 09:45
PMCR- 2024/02/16
CRDT- 2023/03/15 12:14
PHST- 2022/10/07 00:00 [received]
PHST- 2023/02/26 00:00 [accepted]
PHST- 2023/12/17 09:45 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 12:14 [entrez]
PHST- 2024/02/16 00:00 [pmc-release]
AID - 10.1007/s00406-023-01582-1 [pii]
AID - 10.1007/s00406-023-01582-1 [doi]
PST - ppublish
SO  - Eur Arch Psychiatry Clin Neurosci. 2023 Dec;273(8):1825-1835. doi: 
      10.1007/s00406-023-01582-1. Epub 2023 Mar 15.