PMID- 36920671
OWN - NLM
STAT- MEDLINE
DCOM- 20230907
LR  - 20230913
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 30
IP  - 9
DP  - 2023 Sep
TI  - Protective Effect of Akkermansia muciniphila on the Preeclampsia-Like Mouse 
      Model.
PG  - 2623-2633
LID - 10.1007/s43032-023-01206-y [doi]
AB  - Preeclampsia (PE) is known as a metabolism-related complication of pregnancy 
      related to gut dysbiosis including the decreased abundance of Akkermansia 
      muciniphila (A. muciniphila). However, the modulatory role of A. muciniphila as a 
      supplement for PE remains ambiguous. This study investigated the effect of A. 
      muciniphila administration on PE-like mice and its underlying mechanisms. A total 
      of twenty-four C57BL/6 mice were randomly assigned into three groups. PE-like 
      symptoms were induced by continuous injection of L-NAME intraperitoneally from 
      gestational day (GD) 11 to GD18 combined with oral administration of pasteurized 
      A. muciniphila during GD14-18 or not. Mice were sacrificed at GD19 to collect for 
      further evaluation. Decreased A. muciniphila was observed in a successfully 
      established PE-like model than normotensive pregnant control (NP), inversely 
      correlated to increased systolic blood pressure blood and 24-h proteinuria. After 
      supplementing with A. muciniphila, mice showed significantly minimized blood 
      pressure and protein expression in urine, increased number of pups and weight of 
      both embryos and placentas. In addition, colonies of bacteria, inflammatory 
      cytokines (TNF-alpha and IL-6), and metabolic products of lipids including TC, FC, 
      and TG were alleviated by A. muciniphila in the placentas. Among proteins linked 
      with bowel barrier functions, diminished 2-AG and growing ZO-1 and occludin were 
      attributable to A. muciniphila. Also, enhanced Treg/Th17 ratios were found in the 
      intestines of mice treated with A. muciniphila. A. muciniphila facilitated 
      alleviating PE-like symptoms and was beneficial as a novel probiotic therapeutic 
      agent for PE.
CI  - (c) 2023. The Author(s), under exclusive licence to Society for Reproductive 
      Investigation.
FAU - Liu, Wei
AU  - Liu W
AUID- ORCID: 0000-0002-7953-0340
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157, Xiwu Road, Xincheng District, Xi'an, 710004, 
      Shaanxi, China. liuwei2yuan@xjtu.edu.cn.
FAU - Zhang, Tingting
AU  - Zhang T
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157, Xiwu Road, Xincheng District, Xi'an, 710004, 
      Shaanxi, China.
FAU - Wang, Juanni
AU  - Wang J
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157, Xiwu Road, Xincheng District, Xi'an, 710004, 
      Shaanxi, China.
FAU - Zhao, Gang
AU  - Zhao G
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157, Xiwu Road, Xincheng District, Xi'an, 710004, 
      Shaanxi, China.
FAU - Hou, Yuemin
AU  - Hou Y
AD  - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an 
      Jiaotong University, No. 157, Xiwu Road, Xincheng District, Xi'an, 710004, 
      Shaanxi, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230315
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - Akkermansia muciniphila
SB  - IM
MH  - Humans
MH  - Pregnancy
MH  - Female
MH  - Mice
MH  - Animals
MH  - *Pre-Eclampsia
MH  - Mice, Inbred C57BL
MH  - Verrucomicrobia/physiology
MH  - Akkermansia
OTO - NOTNLM
OT  - Akkermansia muciniphila
OT  - Immunity
OT  - Intestinal barrier integrity
OT  - Preeclampsia
EDAT- 2023/03/16 06:00
MHDA- 2023/09/07 06:42
CRDT- 2023/03/15 12:20
PHST- 2022/11/07 00:00 [received]
PHST- 2023/02/26 00:00 [accepted]
PHST- 2023/09/07 06:42 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 12:20 [entrez]
AID - 10.1007/s43032-023-01206-y [pii]
AID - 10.1007/s43032-023-01206-y [doi]
PST - ppublish
SO  - Reprod Sci. 2023 Sep;30(9):2623-2633. doi: 10.1007/s43032-023-01206-y. Epub 2023 
      Mar 15.