PMID- 36920734
OWN - NLM
STAT- MEDLINE
DCOM- 20230925
LR  - 20230925
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 46
IP  - 10
DP  - 2023 Oct
TI  - Threshold of 25(OH)D and consequently adjusted parathyroid hormone reference 
      intervals: data mining for relationship between vitamin D and parathyroid 
      hormone.
PG  - 2067-2077
LID - 10.1007/s40618-023-02057-9 [doi]
AB  - PURPOSE: By recruiting reference population, we aimed to (1): estimate the 
      25(OH)D threshold that maximally inhibits the PTH, which can be defined as the 
      cutoff value for vitamin D sufficiency; (2) establish the PTH reference interval 
      (RI) in population with sufficient vitamin D. METHODS: Study data were retrieved 
      from LIS (Laboratory Information Management System) under literature suggested 
      criteria, and outliers were excluded using Tukey fence method. Locally weighted 
      regression (LOESS) and segmented regression (SR) were conducted to estimate the 
      threshold of 25(OH)D. Multivariate linear regression was performed to evaluate 
      the associations between PTH concentration and variables including 25(OH)D, 
      gender, age, estimated glomerular filtration rate (EGFR), body mass index (BMI), 
      albumin-adjusted serum calcium (aCa), serum phosphate(P), serum magnesium(Mg), 
      and blood collection season. Z test was adopted to evaluate whether the reference 
      interval should be stratified by determinants such as age and gender. RESULTS: A 
      total of 64,979 apparently healthy subjects were recruited in this study, with 
      median (Q1, Q3) 25(OH)D of 45.33 (36.15, 57.50) nmol/L and median (Q1, Q3) PTH of 
      42.19 (34.24, 52.20) ng/L. The segmented regression determined the 25(OH)D 
      threshold of 55 nmol/L above which PTH would somewhat plateau and of 22 nmol/L 
      below which PTH would rise steeply. Multivariate linear regression suggested that 
      gender, EGFR, and BMI were independently associated with PTH concentrations. The 
      PTH RI was calculated as 22.17-72.72 ng/L for subjects with 25(OH)D >/= 55 nmol/L 
      with no necessity of stratification according to gender, age, menopausal status 
      nor season. CONCLUSION: This study reported 25(OH)D thresholds of vitamin D 
      sufficiency at 55 nmol/L and vitamin D deficiency at 22 nmol/L, and consequently 
      established PTH RIs in subjects with sufficient vitamin D for northern China 
      population for the first time.
CI  - (c) 2023. The Author(s).
FAU - Gong, M
AU  - Gong M
AUID- ORCID: 0000-0002-4995-1849
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China.
FAU - Wang, K
AU  - Wang K
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China.
FAU - Sun, H
AU  - Sun H
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China.
FAU - Wang, K
AU  - Wang K
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China.
FAU - Zhou, Y
AU  - Zhou Y
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China.
FAU - Cong, Y
AU  - Cong Y
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China.
FAU - Deng, X
AU  - Deng X
AD  - Department of Laboratory Medicine, Second Medical Center of Chinese PLA General 
      Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, 
      China. bjdxl@163.com.
FAU - Mao, Y
AU  - Mao Y
AD  - Department of Laboratory Medicine, Fifth Medical Center, Chinese PLA General 
      Hospital, Beijing, China. maoyuanlee@163.com.
LA  - eng
GR  - 17BJZ45/Health Bureau of the Military Commission/
PT  - Journal Article
DEP - 20230315
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
RN  - 0 (Vitamins)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Humans
MH  - *Parathyroid Hormone
MH  - Vitamin D
MH  - *Vitamin D Deficiency
MH  - Vitamins
MH  - Calcium
MH  - Data Mining
PMC - PMC10514164
OTO - NOTNLM
OT  - 25(OH)D
OT  - Determinant
OT  - PTH
OT  - Reference interval
OT  - Threshold
COIS- Meiliang Gong, Keyu Wang, Heqiang Sun, Kun Wang, Yu Zhou, Yulong Cong, Xinli 
      Deng, and Yuanli Mao declare that they have no conflict of interest.
EDAT- 2023/03/16 06:00
MHDA- 2023/09/25 06:43
PMCR- 2023/03/15
CRDT- 2023/03/15 12:23
PHST- 2022/10/28 00:00 [received]
PHST- 2023/03/02 00:00 [accepted]
PHST- 2023/09/25 06:43 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 12:23 [entrez]
PHST- 2023/03/15 00:00 [pmc-release]
AID - 10.1007/s40618-023-02057-9 [pii]
AID - 2057 [pii]
AID - 10.1007/s40618-023-02057-9 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2023 Oct;46(10):2067-2077. doi: 10.1007/s40618-023-02057-9. 
      Epub 2023 Mar 15.