PMID- 36921671
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230522
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 365
IP  - 6
DP  - 2023 Jun
TI  - Temporal changes in biomarkers in individuals with and without acute mountain 
      sickness following rapid ascent.
PG  - 510-519
LID - S0002-9629(23)01064-9 [pii]
LID - 10.1016/j.amjms.2023.03.004 [doi]
AB  - BACKGROUND: Field studies have reported conflicting results regarding changes in 
      biomarkers at high altitude. This study measured temporal changes in biomarkers 
      and compared the differences between individuals with and without acute mountain 
      sickness (AMS). MATERIALS AND METHODS: This study included 34 nonacclimatized 
      healthy participants. Ten-milliliters of blood were collected at four time 
      points: 3 days before ascent (T0), on two successive nights at 3150 m (T1 and 
      T2), and 2 days after descent (T3). Participants were transported by bus from 555 
      m to 3150 m within 3 hours. AMS was diagnosed using the self-reported Lake Louise 
      Scoring (LLS) questionnaire. RESULTS: Compared with T0, significant increases in 
      E-selectin and decreases in vascular endothelial growth factor (VEGF) levels were 
      observed at high altitude. Significantly increased C-reactive protein (CRP), 
      monocyte chemoattractant protein-1 (MCP-1), and S100 calcium-binding protein B 
      (S100B) levels were observed at T2, and significantly decreased vascular cell 
      adhesion molecule-1 (VCAM-1) levels were observed at T3. Eighteen (53%) 
      participants developed AMS. Changes in E-selectin, CRP, MCP-1, and S100B levels 
      were independent of AMS. Relative to individuals without AMS, those with AMS had 
      significantly higher atrial natriuretic peptide (ANP) and VCAM-1 levels and lower 
      plasminogen activator inhibitor-1 (PAI-1) levels at T1 and higher brain 
      natriuretic peptide and lower VEGF and PAI-1 levels at T3. LLSs were positively 
      correlated with ANP and VCAM-1 levels and negatively correlated with PAI-1 levels 
      measured at T1. CONCLUSIONS: After acute ascent, individuals with and without AMS 
      exhibited different trends in biomarkers associated with endothelial cell 
      activation and natriuretic peptides.
CI  - Copyright (c) 2023 Southern Society for Clinical Investigation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Lin, Fang-Chi
AU  - Lin FC
AD  - Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Medicine, School of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan. Electronic address: fclin3@vghtpe.gov.tw.
FAU - Chao, Heng-Sheng
AU  - Chao HS
AD  - Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Medicine, School of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Chou, Chung-Wei
AU  - Chou CW
AD  - Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Department of Medicine, School of Medicine, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
FAU - Tsai, Han-Chen
AU  - Tsai HC
AD  - Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan; 
      Institute of Emergency and Critical Care Medicine, School of Medicine, National 
      Yang Ming Chiao Tung University, Taipei, Taiwan.
FAU - Chang, Shi-Chuan
AU  - Chang SC
AD  - Pingtung Christian Hospital, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230313
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0 (E-Selectin)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - *Altitude Sickness/diagnosis
MH  - E-Selectin
MH  - Plasminogen Activator Inhibitor 1
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Cell Adhesion Molecule-1
MH  - Acute Disease
MH  - Biomarkers
OTO - NOTNLM
OT  - Acute mountain sickness
OT  - High-altitude illness
OT  - Lake Louise Score
COIS- Declaration of Competing Interest All authors declare that they have no conflicts 
      of interest.
EDAT- 2023/03/16 06:00
MHDA- 2023/05/15 06:42
CRDT- 2023/03/15 20:26
PHST- 2022/04/05 00:00 [received]
PHST- 2023/02/13 00:00 [revised]
PHST- 2023/03/08 00:00 [accepted]
PHST- 2023/05/15 06:42 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 20:26 [entrez]
AID - S0002-9629(23)01064-9 [pii]
AID - 10.1016/j.amjms.2023.03.004 [doi]
PST - ppublish
SO  - Am J Med Sci. 2023 Jun;365(6):510-519. doi: 10.1016/j.amjms.2023.03.004. Epub 
      2023 Mar 13.