PMID- 36921779
OWN - NLM
STAT- MEDLINE
DCOM- 20230418
LR  - 20230421
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 180
DP  - 2023 May
TI  - The NG2-glia is a potential target to maintain the integrity of neurovascular 
      unit after acute ischemic stroke.
PG  - 106076
LID - S0969-9961(23)00090-6 [pii]
LID - 10.1016/j.nbd.2023.106076 [doi]
AB  - The neurovascular unit (NVU) plays a critical role in health and disease. In the 
      current review, we discuss the critical role of a class of neural/glial antigen 2 
      (NG2)-expressing glial cells (NG2-glia) in regulating NVU after acute ischemic 
      stroke (AIS). We first introduce the role of NG2-glia in the formation of NVU 
      during development as well as aging-induced damage to NVU and accompanying 
      NG2-glia change. We then discuss the reciprocal interactions between NG2-glia and 
      the other component cells of NVU, emphasizing the factors that could influence 
      NG2-glia. Damage to the NVU integrity is the pathological basis of edema and 
      hemorrhagic transformation, the most dreaded complication after AIS. The role of 
      NG2-glia in AIS-induced NVU damage and the effect of NG2-glia transplantation on 
      AIS-induced NVU damage are summarized. We next discuss the role of NG2-glia and 
      the effect of NG2-glia transplantation in oligodendrogenesis and white matter 
      repair as well as angiogenesis which is associated with the outcome of the 
      patients after AIS. Finally, we review the current strategies to promote NG2-glia 
      proliferation and differentiation and propose to use the dental pulp stem cells 
      (DPSC)-derived exosome as a promising strategy to reduce AIS-induced injury and 
      promote repair through maintaining the integrity of NVU by regulating endogenous 
      NG2-glia proliferation and differentiation.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hu, Xiaoyan
AU  - Hu X
AD  - Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of 
      Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation 
      Center for Human Brain Protection, Capital Medical University, Beijing 100069, 
      China.
FAU - Geng, Panpan
AU  - Geng P
AD  - Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of 
      Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation 
      Center for Human Brain Protection, Capital Medical University, Beijing 100069, 
      China.
FAU - Zhao, Xiaoyun
AU  - Zhao X
AD  - Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of 
      Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation 
      Center for Human Brain Protection, Capital Medical University, Beijing 100069, 
      China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of 
      Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation 
      Center for Human Brain Protection, Capital Medical University, Beijing 100069, 
      China.
FAU - Liu, Changqing
AU  - Liu C
AD  - Department of Neurosurgery, Beijing Sanbo Brain Hospital, Capital Medical 
      University, Beijing, China.
FAU - Guo, Chun
AU  - Guo C
AD  - School of Biosciences, University of Sheffield, Firth Court, Western Bank, 
      Sheffield, UK.
FAU - Dong, Wen
AU  - Dong W
AD  - China National Clinical Research Center for Neurological Diseases, Beijing 
      Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address: 
      wen.dong@ncrcnd.org.cn.
FAU - Jin, Xinchun
AU  - Jin X
AD  - Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of 
      Histology and Embryology, School of Basic Medical Sciences, Advanced Innovation 
      Center for Human Brain Protection, Capital Medical University, Beijing 100069, 
      China; Institute of Neuroscience, The Second Affiliated Hospital of Soochow 
      University, Suzhou 215004, China. Electronic address: xinchunjin@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230313
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (chondroitin sulfate proteoglycan 4)
SB  - IM
MH  - Humans
MH  - Cell Differentiation/physiology
MH  - Cell Proliferation/physiology
MH  - *Ischemic Stroke
MH  - Neuroglia/pathology
MH  - *White Matter
OTO - NOTNLM
OT  - NG2-glia
OT  - Neurological functional recovery
OT  - Neurovascular unit
OT  - Stroke
COIS- Declaration of Competing Interest The authors declare that they have no conflicts 
      of interest.
EDAT- 2023/03/16 06:00
MHDA- 2023/04/18 06:42
CRDT- 2023/03/15 20:28
PHST- 2022/12/29 00:00 [received]
PHST- 2023/02/07 00:00 [revised]
PHST- 2023/03/07 00:00 [accepted]
PHST- 2023/04/18 06:42 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 20:28 [entrez]
AID - S0969-9961(23)00090-6 [pii]
AID - 10.1016/j.nbd.2023.106076 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2023 May;180:106076. doi: 10.1016/j.nbd.2023.106076. Epub 2023 Mar 
      13.