PMID- 36921979
OWN - NLM
STAT- MEDLINE
DCOM- 20231225
LR  - 20231225
IS  - 2058-1742 (Electronic)
IS  - 2058-1742 (Linking)
VI  - 9
IP  - 8
DP  - 2023 Dec 22
TI  - Outcomes of ST elevation myocardial infarction in patients with cancer: a 
      nationwide study.
PG  - 806-817
LID - 10.1093/ehjqcco/qcad012 [doi]
AB  - AIMS: To assess processes of care and clinical outcomes in cancer patients with 
      ST elevation myocardial infarction (STEMI) according to cancer type. METHODS AND 
      RESULTS: This is a national population-based study of patients admitted with 
      STEMI in the UK between January 2005 and March 2019. Data were obtained from the 
      National Heart Attack Myocardial Infarction National Audit Project (MINAP) 
      registry and the Hospital Episode Statistics registry. We identified 353 448 
      STEMI-indexed admissions between 2005 and 2019. Of those, 8581 (2.4%) had active 
      cancer. Prostate cancer (29% of STEMI patients with cancer) was the most common 
      cancer followed by haematologic malignancies (14%) and lung cancer (13%). Cancer 
      patients were less likely to receive invasive coronary revascularization (60.0% 
      vs. 71.6%, P < 0.001] and had higher in-hospital death [odd ratio (OR) 1.39, 95% 
      confidence interval (CI) 1.25-1.54] and bleeding (OR 1.23, 95% CI 1.03-1.46). 
      Cancer patients had higher mortality at 30 days (HR 2.39, 95% CI 2.19-2.62) and 1 
      year (HR 3.73, 95% CI 3.58-3.89). Lung cancer was the cancer associated with the 
      highest risk of death in the hospital (OR 1.75, 95% CI 1.39-2.22) and at 1 year 
      (OR 8.08, 95% CI 7.44-8.78). Colon cancer (OR 1.98, 95% CI 1.24-3.14) was the 
      main cancer associated with major bleeding. All common cancer types were 
      associated with higher mortality at 1 year. Cardiovascular death (62%) was the 
      main cause of death in the first 30 days, while cancer (52%) was the main cause 
      of death within 1 year. CONCLUSION: STEMI patients with cancer have a higher risk 
      of short- and long-term mortality, particularly lung cancer. Colon cancer is the 
      main cancer associated with major bleeding. Cardiovascular disease was the main 
      cause of death in the first month, whereas cancer was the main cause of death 
      within 1 year.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      European Society of Cardiology.
FAU - Dafaalla, Mohamed
AU  - Dafaalla M
AUID- ORCID: 0000-0003-4625-2775
AD  - Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele 
      University, Stoke-on-Trent, UK.
FAU - Abdel-Qadir, Husam
AU  - Abdel-Qadir H
AUID- ORCID: 0000-0002-7105-7931
AD  - Department of Medicine and Institute of Health Policy, Management and Evaluation, 
      University of Toronto, Toronto, Canada.
FAU - Gale, Chris P
AU  - Gale CP
AUID- ORCID: 0000-0003-4732-382X
AD  - Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, 
      Leeds, UK.
FAU - Sun, Louise
AU  - Sun L
AD  - Division of Cardiac Anesthesiology, University of Ottawa Heart Institute, Ottawa, 
      Ontario, Canada.
FAU - Lopez-Fernandez, Teresa
AU  - Lopez-Fernandez T
AUID- ORCID: 0000-0002-3414-7022
AD  - Cardiology Department, La Paz University Hospital, IdiPAZ Research Institute, 
      Madrid, Spain.
FAU - Miller, Robert J H
AU  - Miller RJH
AD  - Departments of Medicine (Division of Artificial Intelligence in Medicine), 
      Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, 
      USA.
AD  - Libin Cardiovascular Institute of Alberta and University of Calgary, Calgary, 
      Alberta, Canada.
FAU - Wojakowski, Wojtek
AU  - Wojakowski W
AD  - Division of Cardiology and Structural Heart Diseases, Medical University of 
      Silezia, Katowice, Poland.
FAU - Nolan, James
AU  - Nolan J
AD  - Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele 
      University, Stoke-on-Trent, UK.
FAU - Rashid, Muhammad
AU  - Rashid M
AUID- ORCID: 0000-0001-9725-1583
AD  - Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele 
      University, Stoke-on-Trent, UK.
FAU - Mamas, Mamas A
AU  - Mamas MA
AD  - Keele Cardiovascular Research Group, Centre for Prognosis Research, Keele 
      University, Stoke-on-Trent, UK.
AD  - Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur Heart J Qual Care Clin Outcomes
JT  - European heart journal. Quality of care & clinical outcomes
JID - 101677796
SB  - IM
MH  - Male
MH  - Humans
MH  - *ST Elevation Myocardial Infarction/epidemiology/surgery
MH  - Hospital Mortality
MH  - *Myocardial Infarction
MH  - Hemorrhage
MH  - *Lung Neoplasms/complications/epidemiology
MH  - *Colonic Neoplasms
OTO - NOTNLM
OT  - Cancer
OT  - Care quality
OT  - Outcomes
OT  - STEMI
EDAT- 2023/03/16 06:00
MHDA- 2023/12/25 06:42
CRDT- 2023/03/15 20:52
PHST- 2023/01/25 00:00 [received]
PHST- 2023/02/02 00:00 [revised]
PHST- 2023/02/08 00:00 [accepted]
PHST- 2023/12/25 06:42 [medline]
PHST- 2023/03/16 06:00 [pubmed]
PHST- 2023/03/15 20:52 [entrez]
AID - 7078561 [pii]
AID - 10.1093/ehjqcco/qcad012 [doi]
PST - ppublish
SO  - Eur Heart J Qual Care Clin Outcomes. 2023 Dec 22;9(8):806-817. doi: 
      10.1093/ehjqcco/qcad012.