PMID- 36923012
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230626
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 10
DP  - 2023
TI  - Dry eye disease severity and impact on quality of life in type II diabetes 
      mellitus.
PG  - 1103400
LID - 10.3389/fmed.2023.1103400 [doi]
LID - 1103400
AB  - AIM: To assess the severity of dry eye disease (DED) in humans, its impact on 
      quality of life (QoL) and to grade the damage incurred by the anterior ocular 
      surface in patients diagnosed with type 2 diabetes mellitus (T2DM). PATIENTS AND 
      METHODS: Forty-six patients (mean age +/- SD = 63.8 +/- 6.7 years) diagnosed with 
      T2DM were enrolled in the experimental group and 26 healthy individuals 
      constituted the control group (67.9 +/- 8.9 years). The diagnosis and gradation of 
      DED were conducted in accordance with the International Task Force severity 
      grading scheme. Disease-specific questionnaires were used to obtain the Ocular 
      Surface Disease Index (OSDI) and assess the negative effects of the disease on 
      the patient's QoL. The severity of conjunctival redness and corneal/conjunctival 
      staining was assessed by Efron and Oxford scales, respectively. RESULTS: 
      According to OSDI scores, the entire experimental group presented symptoms of 
      DED: 54.4% were diagnosed with mild DED and 46.6% with moderately severe DED. No 
      cases of severe DED were diagnosed in either the experimental or control group. 
      In the control group, 57.7% of individuals did not have the disease. A 
      significant difference between the experimental and control groups was recorded 
      for both OSDI scores (p  < 0.01) and health-related QoL (p < 0.01). It was 
      observed that keratopathy influenced the mean OSDI values of patients. The mean 
      OSDI value was 25.14 +/- 3 in the experimental group diagnosed with keratopathy, 
      19.3 +/- 3.5 in the subgroup with no indications of corneal injury (p = 0.000002), 
      and 13.0 +/- 3.0 in the control group (p  <  0.000002). Based on the DEWS scheme, a 
      grade I severity level was observed in 46% of control subjects and 33% of 
      patients diagnosed with T2DM (p = 0.4915); grades II and III were detected in the 
      bulk of the experimental group (p = 0.0051; p = 0.1707). None of the subjects in 
      the control or experimental groups manifested grade IV severity of DED. 
      CONCLUSION: In comparison to healthy adults, DED adversely impacts the QoL of 
      type 2 DM patients, regardless of the disease's association with keratopathy.
CI  - Copyright (c) 2023 Zhmud, Malachkova, Redjak, Costagliola, Concilio, Drozhzhyna, 
      Toro Mario and Veretelnyk.
FAU - Zhmud, Tetiana
AU  - Zhmud T
AD  - Department of Ophthalmology, National Pirogov Memorial Medical University, 
      Vinnytsia, Ukraine.
FAU - Malachkova, Natalia
AU  - Malachkova N
AD  - Department of Ophthalmology, National Pirogov Memorial Medical University, 
      Vinnytsia, Ukraine.
FAU - Rejdak, Robert
AU  - Rejdak R
AD  - Department of General and Pediatric Ophthalmology, Medical University of Lublin, 
      Lublin, Poland.
FAU - Costagliola, Ciro
AU  - Costagliola C
AD  - Eye Clinic, Department of Neurosciences, Reproductive and Odontostomatological 
      Sciences, University of Naples Federico II, Naples, Italy.
FAU - Concilio, Marina
AU  - Concilio M
AD  - Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 
      Campobasso, Italy.
FAU - Drozhzhyna, Galyna
AU  - Drozhzhyna G
AD  - Department of Corneal Pathology, SI "Filatov Institute of Eye Diseases and Tissue 
      Therapy of the NAMS of Ukraine", Odesa, Ukraine.
FAU - Toro Mario, Damiano
AU  - Toro Mario D
AD  - Department of General and Pediatric Ophthalmology, Medical University of Lublin, 
      Lublin, Poland.
AD  - Eye Clinic, Public Health Department, University of Naples Federico II, Naples, 
      Italy.
FAU - Veretelnyk, Svitlana
AU  - Veretelnyk S
AD  - Department of Ophthalmology, National Pirogov Memorial Medical University, 
      Vinnytsia, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20230227
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
EIN - Front Med (Lausanne). 2023 May 30;10:1218260. PMID: 37324151
PMC - PMC10009182
OTO - NOTNLM
OT  - Oxford scale
OT  - dry eye disease
OT  - ocular surface disease index
OT  - quality of life
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/17 06:00
MHDA- 2023/03/17 06:01
PMCR- 2023/02/27
CRDT- 2023/03/16 02:15
PHST- 2022/11/20 00:00 [received]
PHST- 2023/02/07 00:00 [accepted]
PHST- 2023/03/16 02:15 [entrez]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/17 06:01 [medline]
PHST- 2023/02/27 00:00 [pmc-release]
AID - 10.3389/fmed.2023.1103400 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2023 Feb 27;10:1103400. doi: 10.3389/fmed.2023.1103400. 
      eCollection 2023.