PMID- 36923657
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230316
IS  - 2214-2509 (Print)
IS  - 2214-2509 (Electronic)
IS  - 2214-2509 (Linking)
VI  - 31
DP  - 2023
TI  - Immune reconstitution inflammatory syndrome in splenic Pneumocystis jirovecii 
      infection: A case report.
PG  - e01729
LID - 10.1016/j.idcr.2023.e01729 [doi]
LID - e01729
AB  - To the best of our knowledge, the present report is the first to describe immune 
      reconstitution inflammatory syndrome (IRIS) in a case of Pneumocystis jirovecii 
      (P. jirovecii) infection of the spleen. A 45-year-old, men who have sex with men 
      patient presented with constipation, abdominal pain, nausea, fever, and weight 
      loss. Human immunodeficiency virus infection and P. jirovecii pneumonia were 
      diagnosed. Abdominal computed tomography revealed multiple, hypodense, cystic 
      lesions in the spleen. Based on the histopathological findings of the lesion 
      obtained from a percutaneous splenic biopsy, extrapulmonary P. jirovecii 
      infection of the spleen was diagnosed. Trimethoprim/sulfamethoxazole was 
      administered for 21 days, and antiretroviral therapy was initiated ten days after 
      the former regimen was begun. Temporary enlargement of the splenic lesions and 
      fever recurrence were observed after the trimethoprim/sulfamethoxazole regimen 
      was completed. However, the clinical course was favorable, with no splenic 
      rupture or splenic bleeding. Our investigation suggested that additional therapy, 
      such as corticosteroid administration, may not be required for IRIS in a splenic 
      P. jirovecii infection, but further research is needed for a definitive 
      conclusion.
CI  - (c) 2023 The Authors. Published by Elsevier Ltd.
FAU - Kojima, Hiroki
AU  - Kojima H
AD  - Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center, Komagome Hospital, 3-18-22 Hon-komagome, Bunkyo-ku, Tokyo 
      113-8677, Japan.
AD  - Department of Infectious Diseases, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 
      Kotobashi, Sumida-ku, Tokyo 130-8575, Japan.
FAU - Tanaka, Masaru
AU  - Tanaka M
AD  - Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center, Komagome Hospital, 3-18-22 Hon-komagome, Bunkyo-ku, Tokyo 
      113-8677, Japan.
FAU - Imamura, Akifumi
AU  - Imamura A
AD  - Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious 
      Diseases Center, Komagome Hospital, 3-18-22 Hon-komagome, Bunkyo-ku, Tokyo 
      113-8677, Japan.
LA  - eng
PT  - Case Reports
DEP - 20230228
PL  - Netherlands
TA  - IDCases
JT  - IDCases
JID - 101634540
PMC - PMC10009051
OTO - NOTNLM
OT  - Extrapulmonary Pneumocystis jirovecii infection
OT  - HIV
OT  - IRIS
OT  - IRIS in splenic Pneumocystis jirovecii infection
OT  - Pneumocystis jirovecii
OT  - Splenic Pneumocystis jirovecii infection
EDAT- 2023/03/17 06:00
MHDA- 2023/03/17 06:01
PMCR- 2023/02/28
CRDT- 2023/03/16 02:26
PHST- 2022/11/19 00:00 [received]
PHST- 2023/02/23 00:00 [revised]
PHST- 2023/02/27 00:00 [accepted]
PHST- 2023/03/16 02:26 [entrez]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/17 06:01 [medline]
PHST- 2023/02/28 00:00 [pmc-release]
AID - S2214-2509(23)00053-7 [pii]
AID - e01729 [pii]
AID - 10.1016/j.idcr.2023.e01729 [doi]
PST - epublish
SO  - IDCases. 2023 Feb 28;31:e01729. doi: 10.1016/j.idcr.2023.e01729. eCollection 
      2023.