PMID- 36924099
OWN - NLM
STAT- MEDLINE
DCOM- 20240507
LR  - 20240513
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 31
IP  - 14
DP  - 2024
TI  - High-sensitivity Troponin (hs-Tn) for Cardiovascular Risk Prognostication: A 
      Systematic Review and Meta-analysis.
PG  - 1941-1953
LID - 10.2174/0929867330666230315152045 [doi]
AB  - BACKGROUND: Chronic low-grade inflammation is involved in coronary 
      atherosclerosis progression whereas recent research efforts suggest that 
      preventative methods should be tailored to the "residual inflammatory risk". As 
      such, modalities for the early identification of the risk have to be 
      investigated. METHODS: We performed a systematic review and meta-analysis 
      according to the PRISMA guidelines. Any study that presented the prognostic value 
      of high sensitivity troponin (hs-cTn) of vascular inflammation in stable patients 
      without known cardiac heart disease was considered to be potentially eligible. 
      The Medline (PubMed) database was searched up to April 22, 2021. The main 
      endpoint was the difference in c-index (Delta[c-index]) with the use of hs-cTn for 
      major adverse cardiovascular events (MACEs), cardiovascular and all-cause 
      mortality. We calculated I(2) to test heterogeneity. RESULTS: In total, 44 
      studies and 112,288 stable patients without known coronary heart disease were 
      included in this meta-analysis. The mean follow-up duration of the whole cohort 
      was 6.8 +/- 1.1 years. 77,004 (68.5%) of the patients presented at low 
      cardiovascular risk while 35,284 (31.5%) in high. The overall pooled estimate of 
      Delta[c-index] for MACE was 1.4% (95%CI: 0.7-2.1, I(2)=0%) and for cardiovascular 
      death 1.3% (95%CI: 0.3-2.3, I(2)=0%). Finally, the overall pooled estimate of 
      Delta[c-index] for all-cause mortality was 3% (95%CI: 1.9-3.9, I(2)=86%), while high 
      heterogeneity was observed between the studies. CONCLUSION: The predictive 
      usefulness of changes in hs-cTn measures in stable individuals with either high 
      or low cardiovascular risk, demonstrates that assessing vascular inflammation in 
      addition to clinical risk factors enhances risk prediction for cardiovascular 
      events and allcause mortality. Further prospective studies are necessary to 
      confirm these findings and assist clinical decision-making regarding the most 
      optimal prevention strategy.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Sagris, Marios
AU  - Sagris M
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Antonopoulos, Alexios S
AU  - Antonopoulos AS
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
AD  - RDM Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
FAU - Angelopoulos, Andreas
AU  - Angelopoulos A
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Papanikolaou, Paraskevi
AU  - Papanikolaou P
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Simantiris, Spyridon
AU  - Simantiris S
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Vamvakaris, Constantinos
AU  - Vamvakaris C
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Koumpoura, Alkmini
AU  - Koumpoura A
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Farmaki, Maria
AU  - Farmaki M
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Antoniades, Charalambos
AU  - Antoniades C
AD  - RDM Division of Cardiovascular Medicine, University of Oxford, Oxford, UK.
FAU - Tsioufis, Constantinos
AU  - Tsioufis C
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
FAU - Tousoulis, Dimitris
AU  - Tousoulis D
AD  - 1st Cardiology Clinic, 'Hippokration' General Hospital, School of Medicine, 
      National and Kapodistrian University of Athens, Athens, Greece.
LA  - eng
GR  - CH/F/21/90009/BHF_/British Heart Foundation/United Kingdom
GR  - TG/16/3/32687/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Biomarkers)
RN  - 0 (Troponin)
SB  - IM
MH  - Humans
MH  - *Cardiovascular Diseases/diagnosis/blood/mortality
MH  - Prognosis
MH  - Biomarkers/blood
MH  - Troponin/blood
OTO - NOTNLM
OT  - cardiovascular disease
OT  - high sensitivity troponin
OT  - hs-Tn
OT  - inflammation
OT  - prevention.
OT  - prognosis
EDAT- 2023/03/17 06:00
MHDA- 2024/05/07 06:42
CRDT- 2023/03/16 03:44
PHST- 2022/08/02 00:00 [received]
PHST- 2023/01/12 00:00 [revised]
PHST- 2023/01/19 00:00 [accepted]
PHST- 2024/05/07 06:42 [medline]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/16 03:44 [entrez]
AID - CMC-EPUB-130176 [pii]
AID - 10.2174/0929867330666230315152045 [doi]
PST - ppublish
SO  - Curr Med Chem. 2024;31(14):1941-1953. doi: 10.2174/0929867330666230315152045.