PMID- 36924161
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230320
IS  - 2049-4408 (Electronic)
IS  - 2049-4394 (Linking)
VI  - 105-B
IP  - 4
DP  - 2023 Mar 15
TI  - Primary knee arthroplasty for osteoarthritis restores patients' health-related 
      quality of life to normal population levels.
PG  - 365-372
LID - 10.1302/0301-620X.105B4.BJJ-2022-0659.R1 [doi]
AB  - This study investigates whether primary knee arthroplasty (KA) restores 
      health-related quality of life (HRQoL) to levels expected in the general 
      population. This retrospective case-control study compared HRQoL data from two 
      sources: patients undergoing primary KA in a university-teaching hospital (2013 
      to 2019), and the Health Survey for England (HSE; 2010 to 2012). Patient-level 
      data from the HSE were used to represent the general population. Propensity score 
      matching was used to balance covariates and facilitate group comparisons. A 
      propensity score was estimated using logistic regression based upon the 
      covariates sex, age, and BMI. Two matched cohorts with 3,029 patients each were 
      obtained for the adjusted analyses (median age 70.3 (interquartile range (IQR) 64 
      to 77); number of female patients 3,233 (53.4%); median BMI 29.7 kg/m(2) (IQR 
      26.5 to 33.7)). HRQoL was measured using the three-level version of the EuroQol 
      five-dimension questionnaire (EQ-5D-3L), and summarized using the Index and 
      EuroQol visual analogue scale (EQ-VAS) scores. Patients awaiting KA had 
      significantly lower EQ-5D-3L Index scores than the general population (median 
      0.620 (IQR 0.16 to 0.69) vs median 0.796 (IQR 0.69 to 1.00); p < 0.001). By one 
      year postoperatively, the median EQ-5D-3L Index score improved significantly in 
      the KA cohort (mean change 0.32 (SD 0.33); p < 0.001), and demonstrated no 
      clinically relevant differences when compared to the general population (median 
      0.796 (IQR 0.69 to 1.00) vs median 0.796 (IQR 0.69 to 1.00)). Compared to the 
      general population cohort, the postoperative EQ-VAS was significantly higher in 
      the KA cohort (p < 0.001). Subgroup comparisons demonstrated that older age 
      groups had statistically better EQ-VAS scores than matched peers in the general 
      population. Patients awaiting KA for osteoarthritis had significantly poorer 
      HRQoL than the general population. However, within one year of surgery, primary 
      KA restored HRQoL to levels expected for the patient's age-, BMI-, and 
      sex-matched peers.
CI  - (c) 2023 The British Editorial Society of Bone & Joint Surgery.
FAU - Yapp, Liam Z
AU  - Yapp LZ
AUID- ORCID: 0000-0003-2180-8933
AD  - Department of Orthopaedics, Division of Clinical and Surgical Sciences, 
      University of Edinburgh, Edinburgh, UK.
AD  - Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, 
      Edinburgh, UK.
FAU - Scott, Chloe E H
AU  - Scott CEH
AUID- ORCID: 0000-0002-0012-1596
AD  - Department of Orthopaedics, Division of Clinical and Surgical Sciences, 
      University of Edinburgh, Edinburgh, UK.
AD  - Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, 
      Edinburgh, UK.
FAU - MacDonald, Deborah J
AU  - MacDonald DJ
AUID- ORCID: 0000-0003-2682-1408
AD  - Department of Orthopaedics, Division of Clinical and Surgical Sciences, 
      University of Edinburgh, Edinburgh, UK.
AD  - Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, 
      Edinburgh, UK.
FAU - Howie, Colin R
AU  - Howie CR
AUID- ORCID: 0000-0001-6656-2821
AD  - Department of Orthopaedics, Division of Clinical and Surgical Sciences, 
      University of Edinburgh, Edinburgh, UK.
AD  - Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, 
      Edinburgh, UK.
FAU - Simpson, A Hamish R W
AU  - Simpson AHRW
AUID- ORCID: 0000-0001-7793-642X
AD  - Department of Orthopaedics, Division of Clinical and Surgical Sciences, 
      University of Edinburgh, Edinburgh, UK.
AD  - Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, 
      Edinburgh, UK.
AD  - Bone & Joint Research , London, UK.
FAU - Clement, Nick D
AU  - Clement ND
AUID- ORCID: 0000-0001-8792-0659
AD  - Department of Orthopaedics, Division of Clinical and Surgical Sciences, 
      University of Edinburgh, Edinburgh, UK.
AD  - Department of Trauma & Orthopaedic Surgery, Royal Infirmary of Edinburgh, 
      Edinburgh, UK.
LA  - eng
PT  - Journal Article
DEP - 20230315
PL  - England
TA  - Bone Joint J
JT  - The bone & joint journal
JID - 101599229
SB  - IM
MH  - Humans
MH  - Female
MH  - Aged
MH  - Quality of Life
MH  - *Arthroplasty, Replacement, Knee
MH  - Retrospective Studies
MH  - Case-Control Studies
MH  - *Osteoarthritis
MH  - Surveys and Questionnaires
COIS- N. D. Clement is a member of the editorial board of Bone & Joint Open, Bone & 
      Joint 360, and The Bone & Joint Journal. C. E. H. Scott reports an institutional 
      research grant from Stryker, and consulting fees from Stryker and Smith & Nephew, 
      all of which are unrelated to this study. C. E. H. Scott is also a member of the 
      editorial boards of The Bone & Joint Journal and Bone & Joint Research, and is on 
      an advisory board for Pfizer. A. H. R. W. Simpson is the Editor-in-Chief of Bone 
      & Joint Research, and reports multiple grants from RCUK, Charities, and Stryker, 
      unrelated to this study.
EDAT- 2023/03/17 06:00
MHDA- 2023/03/21 06:00
CRDT- 2023/03/16 04:32
PHST- 2023/03/16 04:32 [entrez]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
AID - BJJ-2022-0659.R1 [pii]
AID - 10.1302/0301-620X.105B4.BJJ-2022-0659.R1 [doi]
PST - epublish
SO  - Bone Joint J. 2023 Mar 15;105-B(4):365-372. doi: 
      10.1302/0301-620X.105B4.BJJ-2022-0659.R1.