PMID- 36924239
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230320
IS  - 1525-6006 (Electronic)
IS  - 1064-1963 (Linking)
VI  - 45
IP  - 1
DP  - 2023 Dec 31
TI  - Establishment of a canine model of pulmonary arterial hypertension induced by 
      dehydromonocrotaline and ultrasonographic study of right ventricular remodeling.
PG  - 2190503
LID - 10.1080/10641963.2023.2190503 [doi]
AB  - OBJECTIVE: Pulmonary arterial hypertension (PAH) means high blood pressure in the 
      lungs. We aimed to observe the right ventricular size, wall thickness and 
      characteristic functional changes and their associations with PAH in an 
      established model of beagle dogs, and to explore convenient, reliable and 
      sensitive ultrasound indicators for assessing right ventricular remodeling. 
      METHODS: Twenty healthy beagle dogs (8-10 kg) were randomly divided into control 
      group (N-dimethylformamide, n = 10) and dehydromonocrotaline (DHMCT) group 
      (DHMCT, n = 10). N-dimethylformamide or DHMCT was injected through a catheter 
      into the right atrium, and then right heart catheterization, routine 
      echocardiography and two-dimensional speckle tracking imaging (2D-STI) were 
      performed before modeling (0 weeks) and 8, 14 weeks after modeling. Hemodynamic 
      parameters and right ventricular function-related ultrasound data were acquired. 
      At the end of the experiment, the animals were killed and the lung tissues were 
      taken for HE staining. Left and right ventricular walls were separated and 
      weighed respectively, and right ventricular hypertrophy index (RVHI) was 
      measured. The associations of the routine ultrasound data and 2D-STI data at each 
      time point with hemodynamic parameters and RVHI were analyzed. RESULTS: At 0, 8 
      and 14 weeks, gradual decreases in the right ventricular global longitudinal 
      strain (RVLS) were found in DHMCT group. RVH occurred in DHMCT group, and DHMCT 
      group had a significantly higher RVHI than that of control group (49.83 +/- 4.83% 
      vs. 39.80 +/- 1.40%, P < .001) and larger pulmonary artery media thickness. RVLS 
      had significant positive correlations with RVSP (r = 0.74, P < .001), mRVP 
      (r = 0.72, P < .001), PASP (r = 0.75, P < .001), mPAP (r = 0.72, P < .001) and 
      PVR (r = 0.68, P < .001). There was a significant positive correlation between 
      RVLS and RVHI (r = 0.74, P < .001). CONCLUSION: The right ventricular function in 
      PAH can be effectively assessed by echocardiography, and RVLS measured by 2D-STI 
      sensitively reflects right ventricular remodeling following PAH.
FAU - Dong, Jing
AU  - Dong J
AD  - Department of Cardiovascular Ultrasound, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Jiang, Xiao-Min
AU  - Jiang XM
AD  - Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, Jiangsu Province, China.
FAU - Xie, Du-Jiang
AU  - Xie DJ
AD  - Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, Jiangsu Province, China.
FAU - Luo, Jie
AU  - Luo J
AD  - Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, Jiangsu Province, China.
FAU - Ran, Hong
AU  - Ran H
AD  - Department of Cardiovascular Ultrasound, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Li, Lin
AU  - Li L
AD  - Department of Cardiovascular Ultrasound, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Li, Miao
AU  - Li M
AD  - Department of Cardiovascular Ultrasound, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Jiang, Pei
AU  - Jiang P
AD  - Department of Cardiovascular Ultrasound, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Zhang, Ping-Yang
AU  - Zhang PY
AD  - Department of Cardiovascular Ultrasound, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, Jiangsu Province, China.
FAU - Zhou, Ling
AU  - Zhou L
AD  - Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Hypertens
JT  - Clinical and experimental hypertension (New York, N.Y. : 1993)
JID - 9305929
RN  - 23291-96-5 (monocrotaline pyrrole)
RN  - 8696NH0Y2X (Dimethylformamide)
SB  - IM
MH  - Dogs
MH  - Animals
MH  - *Pulmonary Arterial Hypertension
MH  - *Hypertension, Pulmonary/diagnostic imaging/etiology
MH  - Ventricular Remodeling
MH  - Dimethylformamide
MH  - Hypertrophy, Right Ventricular/diagnostic imaging/etiology
MH  - Ventricular Function, Right
MH  - *Ventricular Dysfunction, Right
OTO - NOTNLM
OT  - Dehydromonocrotaline
OT  - echocardiography
OT  - pulmonary arterial hypertension
OT  - right ventricular remodeling
OT  - two-dimensional speckle tracking
EDAT- 2023/03/17 06:00
MHDA- 2023/03/21 06:00
CRDT- 2023/03/16 05:13
PHST- 2023/03/16 05:13 [entrez]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
AID - 10.1080/10641963.2023.2190503 [doi]
PST - ppublish
SO  - Clin Exp Hypertens. 2023 Dec 31;45(1):2190503. doi: 
      10.1080/10641963.2023.2190503.