PMID- 36924394
OWN - NLM
STAT- MEDLINE
DCOM- 20230517
LR  - 20230911
IS  - 1473-656X (Electronic)
IS  - 1040-872X (Linking)
VI  - 35
IP  - 3
DP  - 2023 Jun 1
TI  - New insights into decidualization: immunological and genetic factors.
PG  - 193-199
LID - 10.1097/GCO.0000000000000829 [doi]
AB  - PURPOSE OF REVIEW: Nowadays, there are many efforts focused on improving embryo 
      quality for assisted reproduction treatments. Nevertheless, there are important 
      maternal aspects, such as decidualization, also essential for pregnancy, often 
      forgotten. With this review, we intend to highlight the main events involved in 
      this endometrial phenomenon, as well as the cells and molecules that have 
      recently been related to it. RECENT FINDINGS: Decidualization entails a complete 
      transformation of the endometrium, with recent research reaffirming progesterone 
      as its main molecular trigger. Certain immune components and membrane molecules 
      have also been found to play a role in it, notably the killer immunoglobulin-like 
      receptors (KIR) of uterine natural killer (uNK) cells, as well as the human 
      leukocyte antigen (HLA)-F. SUMMARY: Progesterone directs the cellular changes 
      that take place during decidualization, as well as the recruitment and maturation 
      of uNKs, along with the coordinated action of interleukin-15. Likewise, the role 
      of KIR and HLA-F in this process and in the subsequent development of pregnancy 
      is being highlighted in many studies, with effects on reproductive outcomes 
      related to the different genotypes of these molecules.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Cuadrado-Torroglosa, Isabel
AU  - Cuadrado-Torroglosa I
AD  - IVI Foundation, Health Research Institute La Fe, Valencia.
FAU - Garcia-Velasco, Juan Antonio
AU  - Garcia-Velasco JA
AD  - IVI Foundation, Health Research Institute La Fe, Valencia.
AD  - Department of Reproductive Endocrinology and Infertility, IVI RMA.
AD  - Rey Juan Carlos University.
FAU - Alecsandru, Diana
AU  - Alecsandru D
AD  - IVI Foundation, Health Research Institute La Fe, Valencia.
AD  - Department of Immunology, IVI RMA, Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230314
PL  - England
TA  - Curr Opin Obstet Gynecol
JT  - Current opinion in obstetrics & gynecology
JID - 9007264
RN  - 4G7DS2Q64Y (Progesterone)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - *Progesterone
MH  - *Embryo Implantation/genetics
MH  - Uterus
MH  - Endometrium
EDAT- 2023/03/17 06:00
MHDA- 2023/05/17 06:42
CRDT- 2023/03/16 06:42
PHST- 2023/05/17 06:42 [medline]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/16 06:42 [entrez]
AID - 00001703-202306000-00004 [pii]
AID - 10.1097/GCO.0000000000000829 [doi]
PST - ppublish
SO  - Curr Opin Obstet Gynecol. 2023 Jun 1;35(3):193-199. doi: 
      10.1097/GCO.0000000000000829. Epub 2023 Mar 14.