PMID- 36924407
OWN - NLM
STAT- MEDLINE
DCOM- 20230403
LR  - 20230512
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 43
IP  - 3
DP  - 2023 Mar 31
TI  - HOTAIR as a diagnostic and prognostic biomarker of gastrointestinal cancers: an 
      updated meta-analysis and bioinformatics analysis based on TCGA data.
LID - 10.1042/BSR20222174 [doi]
LID - BSR20222174
AB  - Gastrointestinal cancers are the most common type of cancer affecting humans. 
      High expression of HOX transcript antisense intergenic RNA (HOTAIR), a long 
      noncoding RNA (lncRNA), in various types of different tumors may be associated 
      with poor prognosis. In the present study, we performed a meta-analysis of the 
      relationship between HOTAIR expression and gastrointestinal cancers. Five 
      databases were comprehensively searched for all literature until January 2023. 
      Moreover, the target genes of HOTAIR were predicted by coexpression analysis 
      based on The Cancer Genome Atlas (TCGA) gene expression matrix for six 
      gastrointestinal cancer types. Finally, the mechanism through which HOTAIR 
      affects tumors of the digestive system was systematically reviewed. Our results 
      showed that the high HOTAIR expression group had worse outcomes with a pooled 
      hazard ratio (HR) of 1.56 (95% confidence interval [CI] = 1.38-1.75, P<0.001). 
      Furthermore, HOTAIR was identified as an unfavorable prognostic factor for 
      overall survival (OS) in the esophageal carcinoma (ESCA) and gastric cancer (GC), 
      as the HR were 1.94 and 1.58, respectively. The high correlation between the 
      expression of homeobox C (HOXC) family genes and HOTAIR, with correlation 
      coefficients of 0.863 (HOXC11), 0.664 (HOXC10), 0.645 (HOXC8), and 0.581 
      (HOXC12). The 'cell cycle' pathway and pathways relating to infections, namely 
      'herpes simplex virus 1 infection' and 'complement and coagulation cascades' were 
      significantly enriched in Kyoto Encyclopedia of Genes and Genomes (KEGG) 
      analysis. Also, we perform a systematic review to summarize the related oncogenic 
      mechanism of HOTAIR. In conclusion, the HOTAIR has been identified as a potential 
      prognostic factor in patients with gastrointestinal cancers.
CI  - (c) 2023 The Author(s).
FAU - Yang, Jinyou
AU  - Yang J
AD  - Department of Health and Rehabilitation, Jiangsu College of Nursing, Huai'an, 
      Jiangsu 223005, P. R. China.
FAU - Xu, Shuyu
AU  - Xu S
AD  - Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, 
      Department of Occupational Medicine and Environmental Health, School of Public 
      Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. 
      China.
FAU - Wang, Shaozhuo
AU  - Wang S
AD  - Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, 
      Department of Occupational Medicine and Environmental Health, School of Public 
      Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. 
      China.
FAU - Zou, Xuyan
AU  - Zou X
AD  - Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, 
      Department of Occupational Medicine and Environmental Health, School of Public 
      Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. 
      China.
FAU - Duan, Mingxiu
AU  - Duan M
AD  - Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, 
      Department of Occupational Medicine and Environmental Health, School of Public 
      Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. 
      China.
FAU - Zhang, Qiaoling
AU  - Zhang Q
AD  - Department of Nursing and Midwifery, Jiangsu College of Nursing, Huai'an, Jiangsu 
      223005, P. R. China.
FAU - Wang, Chao
AU  - Wang C
AUID- ORCID: 0000-0001-8452-1214
AD  - Key Lab of Modern Toxicology of Ministry of Education, Center for Global Health, 
      Department of Occupational Medicine and Environmental Health, School of Public 
      Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing 211166, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (Biomarkers)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (HOXC10 protein, human)
RN  - 0 (HOXC11 protein, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (HOTAIR long untranslated RNA, human)
SB  - IM
MH  - Humans
MH  - Biomarkers
MH  - *Esophageal Neoplasms/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Homeodomain Proteins/genetics
MH  - Prognosis
MH  - *RNA, Long Noncoding/genetics/metabolism
MH  - *Stomach Neoplasms/diagnosis/genetics
PMC - PMC10064413
OTO - NOTNLM
OT  - Hox transcript antisense intergenic RNA
OT  - cancer
OT  - digestive system
OT  - long noncoding RNA
OT  - meta-analysis
OT  - prognosis
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2023/03/17 06:00
MHDA- 2023/03/30 06:11
PMCR- 2023/03/29
CRDT- 2023/03/16 06:52
PHST- 2022/10/25 00:00 [received]
PHST- 2023/03/02 00:00 [revised]
PHST- 2023/03/13 00:00 [accepted]
PHST- 2023/03/30 06:11 [medline]
PHST- 2023/03/17 06:00 [pubmed]
PHST- 2023/03/16 06:52 [entrez]
PHST- 2023/03/29 00:00 [pmc-release]
AID - 232737 [pii]
AID - BSR20222174 [pii]
AID - 10.1042/BSR20222174 [doi]
PST - ppublish
SO  - Biosci Rep. 2023 Mar 31;43(3):BSR20222174. doi: 10.1042/BSR20222174.