PMID- 36927187
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230322
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 131
IP  - 3
DP  - 2023 Mar
TI  - Nutritional Modulation of Associations between Prenatal Exposure to Persistent 
      Organic Pollutants and Childhood Obesity: A Prospective Cohort Study.
PG  - 37011
LID - 10.1289/EHP11258 [doi]
LID - 037011
AB  - BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) may 
      contribute to the development of childhood obesity and metabolic disorders. 
      However, little is known about whether the maternal nutritional status during 
      pregnancy can modulate these associations. OBJECTIVES: The main objective was to 
      characterize the joint associations and interactions between prenatal levels of 
      POPs and nutrients on childhood obesity. METHODS: We used data from to the 
      Spanish INfancia y Medio Ambiente-Environment and Childhood (INMA) birth cohort, 
      on POPs and nutritional biomarkers measured in maternal blood collected at the 
      first trimester of pregnancy and child anthropometric measurements at 7 years of 
      age. Six organochlorine compounds (OCs) [dichlorodiphenyldichloroethylene, 
      hexachlorobenzene (HCB), beta - hexachlorocyclohexane (beta - HCH) and polychlorinated 
      biphenyls 138, 153, 180] and four per- and polyfluoroalkyl substances (PFAS) were 
      measured. Nutrients included vitamins (D, B12, and folate), polyunsaturated fatty 
      acids (PUFAs), and dietary carotenoids. Two POPs-nutrients mixtures data sets 
      were established: a) OCs, PFAS, vitamins, and carotenoids (n = 660), and b) OCs, 
      PUFAs, and vitamins (n = 558). Joint associations of mixtures on obesity were 
      characterized using Bayesian kernel machine regression (BKMR). Relative 
      importance of biomarkers and two-way interactions were identified using gradient 
      boosting machine, hierarchical group lasso regularization, and BKMR. Interactions 
      were further characterized using multivariate regression models in the 
      multiplicative and additive scale. RESULTS: Forty percent of children had 
      overweight or obesity. We observed a positive overall joint association of both 
      POPs-nutrients mixtures on overweight/obesity risk, with HCB and vitamin B12 the 
      biomarkers contributing the most. Recurrent interactions were found between HCB 
      and vitamin B12 across screening models. Relative risk for a natural log increase 
      of HCB was 1.31 (95% CI: 1.11, 1.54, pInteraction = 0.02) in the tertile 2 of 
      vitamin B12 and in the additive scale a relative excess risk due to interaction 
      of 0.11 (95% CI: 0.02, 0.20) was found. Interaction between perfluorooctane 
      sulfonate and beta - cryptoxanthin suggested a protective effect of the antioxidant 
      on overweight/obesity risk. CONCLUSION: These results support that maternal 
      nutritional status may modulate the effect of prenatal exposure to POPs on 
      childhood overweight/obesity. These findings may help to develop a biological 
      hypothesis for future toxicological studies and to better interpret inconsistent 
      findings in epidemiological studies. https://doi.org/10.1289/EHP11258.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - Laboratory for the Study of Residues and Contaminants in Foods (LABERCA), Oniris, 
      Institut national de la recherche agronomique (INRAE), Nantes, France.
FAU - Warembourg, Charline
AU  - Warembourg C
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Institut de recherche en sante, environnement et travail (IRSET), Ecole des 
      hautes etudes en sante publique (EHESP), Unite Mixte de Recherche (UMR) 1085 
      Institut national de la sante et de la recherche medicale (INSERM), Universite de 
      Rennes, Rennes, France.
FAU - Guil, Nuria
AU  - Guil N
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Stratakis, Nikos
AU  - Stratakis N
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
FAU - Lertxundi, Aitana
AU  - Lertxundi A
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Biodonostia, Unidad de Epidemiologia Ambiental y Desarrollo Infantil, San 
      Sebastian, Gipuzkoa, Spain.
AD  - Facultad de Medicina, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, 
      Leioa, Bizkaia, Spain.
FAU - Irizar, Amaia
AU  - Irizar A
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Biodonostia, Unidad de Epidemiologia Ambiental y Desarrollo Infantil, San 
      Sebastian, Gipuzkoa, Spain.
AD  - Facultad de Medicina, Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, 
      Leioa, Bizkaia, Spain.
FAU - Llop, Sabrina
AU  - Llop S
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Epidemiology and Environmental Health Joint Research Unit, Foundation for the 
      Promotion of Health and Biomedical Research in the Valencian Region, Foundation 
      for the Promotion of Health and Biomedical Research in the Valencian Community 
      (FISABIO)-Public Health, FISABIO-Universitat Jaume I-Universitat de Valencia, 
      Valencia, Valencia, Spain.
FAU - Lopez-Espinosa, Maria-Jose
AU  - Lopez-Espinosa MJ
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
AD  - Epidemiology and Environmental Health Joint Research Unit, Foundation for the 
      Promotion of Health and Biomedical Research in the Valencian Region, Foundation 
      for the Promotion of Health and Biomedical Research in the Valencian Community 
      (FISABIO)-Public Health, FISABIO-Universitat Jaume I-Universitat de Valencia, 
      Valencia, Valencia, Spain.
AD  - Faculty of Nursing and Chiropody, University of Valencia, Valencia, Valencia, 
      Spain.
FAU - Basagana, Xavier
AU  - Basagana X
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Gonzalez, Juan Ramon
AU  - Gonzalez JR
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Coumoul, Xavier
AU  - Coumoul X
AD  - Institut national de la sante et de la recherche medicale (INSERM) UMR-S1124, 
      Universite de Paris, Paris, France.
FAU - Fernandez-Barres, Silvia
AU  - Fernandez-Barres S
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Antignac, Jean-Philippe
AU  - Antignac JP
AD  - Laboratory for the Study of Residues and Contaminants in Foods (LABERCA), Oniris, 
      Institut national de la recherche agronomique (INRAE), Nantes, France.
FAU - Vrijheid, Martine
AU  - Vrijheid M
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
FAU - Casas, Maribel
AU  - Casas M
AUID- ORCID: 0000-0002-2112-6740
AD  - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
AD  - Pompeu Fabra University, Barcelona, Spain.
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230316
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Persistent Organic Pollutants)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Vitamins)
RN  - P6YC3EG204 (Vitamin B 12)
RN  - 0 (Fluorocarbons)
SB  - IM
CIN - Environ Health Perspect. 2023 Mar;131(3):31306. PMID: 36927188
MH  - Pregnancy
MH  - Female
MH  - Humans
MH  - Child
MH  - *Pediatric Obesity/chemically induced/epidemiology
MH  - Persistent Organic Pollutants
MH  - *Prenatal Exposure Delayed Effects/epidemiology
MH  - Overweight
MH  - Prospective Studies
MH  - Hexachlorobenzene
MH  - Bayes Theorem
MH  - *Environmental Pollutants
MH  - *Hydrocarbons, Chlorinated
MH  - Vitamins
MH  - Vitamin B 12
MH  - *Fluorocarbons
PMC - PMC10019508
EDAT- 2023/03/18 06:00
MHDA- 2023/03/21 06:00
PMCR- 2023/03/16
CRDT- 2023/03/17 08:09
PHST- 2023/03/17 08:09 [entrez]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/03/16 00:00 [pmc-release]
AID - EHP11258 [pii]
AID - 10.1289/EHP11258 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2023 Mar;131(3):37011. doi: 10.1289/EHP11258. Epub 2023 
      Mar 16.