PMID- 36927410
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230320
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 24
IP  - 1
DP  - 2023 Mar 16
TI  - Does type 2 diabetes affect the efficacy of therapeutic exercises for 
      degenerative lumbar spinal stenosis?
PG  - 198
LID - 10.1186/s12891-023-06305-0 [doi]
LID - 198
AB  - DESIGN: Propensity-matched retrospective study. OBJECTIVES: To determine whether 
      type 2 diabetes mellitus (T2D) would affect prognosis in patients with 
      degenerative lumbar spinal stenosis (DLSS) who underwent therapeutic exercises. 
      METHODS: This study included consecutive patients with or without T2D who 
      underwent therapeutic exercises for symptomatic DLSS from December 2018 to 
      January 2020. Baseline demographics and clinical and radiological data were 
      collected. The 2 groups of patients were further matched in a 1:1 fashion based 
      on the propensity score, balancing the groups on pre-treatment factors including 
      age, sex, leg and back pain, and low back disability. The primary outcomes 
      included self-reported leg pain intensity (Numerical Rating Scale, NRS) and low 
      back disability (Oswestry Disability Index, ODI) and the secondary outcomes 
      included low back pain intensity and walking capacity (self-paced walking test, 
      SPWT) were compared at baseline, 6 weeks, and 12 weeks. RESULTS: Forty-one pairs 
      of patients were selected by propensity matching. After 6-week therapeutic 
      exercises, patients with T2D achieved a lower improvement in leg pain at 6 weeks 
      (NRS leg change, 1.21 +/- 0.40 vs. 1.78 +/- 0.52, P = 0.021) and 12 weeks (NRS leg 
      change, 1.52 +/- 0.92 vs. 2.18 +/- 0.96, P = 0.007) above minimal clinically 
      important difference (MCID), with a significant Group x Time interactions 
      (F(1,80) = 16.32, p < 0.001, etap2 = 0.053). However, the two groups showed no 
      difference in the improvement of ODI, although the sample had significant 
      improvements at 6 weeks (ODI change 3.02 [95% CI, 2.08 to 2.77], P < 0.001) and 
      12 weeks ([ODI change 3.82 [95% CI, 4.03 to 4.90], P < 0.001), 46% of the 
      patients achieved an MCID. CONCLUSION: Six-week therapeutic exercises have an 
      inferior effect on DLSS patients with T2D. Findings from this study will provide 
      an increased understanding of exercise treatment in patients with DLSS.
CI  - (c) 2023. The Author(s).
FAU - Shi, Tengbin
AU  - Shi T
AD  - Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Chen, Zhi
AU  - Chen Z
AD  - Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Hu, Dingxiang
AU  - Hu D
AD  - School of Health, Fujian Medical University, 350108, Fuzhou, Fujian, China.
FAU - Li, Wenwen
AU  - Li W
AD  - School of Health, Fujian Medical University, 350108, Fuzhou, Fujian, China.
FAU - Wang, Zhenyu
AU  - Wang Z
AD  - Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, 
      China.
FAU - Liu, Wenge
AU  - Liu W
AD  - Department of Orthopedics, Fujian Medical University Union Hospital, Fuzhou, 
      China. wengeunion@fjmu.edu.cn.
AD  - School of Health, Fujian Medical University, 350108, Fuzhou, Fujian, China. 
      wengeunion@fjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230316
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
SB  - IM
MH  - Humans
MH  - *Spinal Stenosis/complications/therapy
MH  - Retrospective Studies
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - Back Pain/complications
MH  - Prognosis
MH  - Lumbar Vertebrae/diagnostic imaging
MH  - Treatment Outcome
PMC - PMC10018869
OTO - NOTNLM
OT  - Exercise therapy
OT  - Fatty infiltration
OT  - Lumbar spinal stenosis
OT  - Multifidus muscle
OT  - Type 2 diabetes
COIS- The author(s) declared no potential conflicts of interest concerning the 
      research, authorship, and/or publication of this article.
EDAT- 2023/03/18 06:00
MHDA- 2023/03/21 06:00
PMCR- 2023/03/16
CRDT- 2023/03/17 08:20
PHST- 2022/11/29 00:00 [received]
PHST- 2023/03/09 00:00 [accepted]
PHST- 2023/03/17 08:20 [entrez]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/03/16 00:00 [pmc-release]
AID - 10.1186/s12891-023-06305-0 [pii]
AID - 6305 [pii]
AID - 10.1186/s12891-023-06305-0 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2023 Mar 16;24(1):198. doi: 10.1186/s12891-023-06305-0.