PMID- 36927467
OWN - NLM
STAT- MEDLINE
DCOM- 20230320
LR  - 20230325
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 23
IP  - 1
DP  - 2023 Mar 16
TI  - Association of feeding patterns in infancy with later autism symptoms and 
      neurodevelopment: a national multicentre survey.
PG  - 174
LID - 10.1186/s12888-023-04667-2 [doi]
LID - 174
AB  - BACKGROUND: We aimed to compare differences in infant feeding patterns 
      (breastfeeding and complementary food supplementation) between children with the 
      autism spectrum disorder (ASD) and typically developing (TD) children through a 
      multicentre study. The relationship between these patterns and later core 
      symptoms and neurodevelopment in children with ASD was also investigated. 
      METHODS: We analysed breastfeeding and complementary feeding patterns in 1389 
      children with ASD and 1190 TD children. The Children Neuropsychological and 
      Behavior Scale-Revision 2016 (CNBS-R2016) was used to assess neurodevelopmental 
      levels. The Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS), 
      Childhood Autism Rating Scale (CARS), and ASD Warning Behavior Subscale of the 
      CNBS-R2016 were used to assess ASD symptoms. RESULTS: Children with ASD had a 
      shorter breastfeeding duration in infancy (8 (3-12) months vs. 10 (6-14) months, 
      P < 0.001), later introduction of complementary foods (P < 0.001), and poorer 
      acceptance of complementary foods (P < 0.001) than TD children. Total ABC and 
      CARS scores were lower in the group of children with ASD who had been breastfed 
      for 12 months or more than in the group who had been breastfed for less than 
      6 months. Children with ASD who were given complementary food after 6 months had 
      lower general quotient (GQ), adaptive ability, fine motor and language scores 
      than those who were given complementary food within 4-6 months. Children with ASD 
      with poor acceptance of complementary foods had higher ABC and SRS scores and 
      lower gross motor scores than those who had good acceptance. CONCLUSIONS: 
      Children with ASD have a shorter duration of breastfeeding, a later introduction 
      of complementary foods, and poorer acceptance of complementary foods than TD 
      children. These feeding patterns may be related to the symptoms and growth of 
      children with ASD. The research suggests that continued breastfeeding for longer 
      than 12 months may be beneficial in reducing ASD symptoms and that infants who 
      have difficulty introducing complementary foods should be followed up for 
      neurodevelopment. TRIAL REGISTRATION: The ethics committee of the Children's 
      Hospital of Chongqing Medical University approved the study. Approval Number: 
      (2018) IRB (STUDY) NO. 121, and registered in the Chinese Clinical Trial Registry 
      (Registration number: ChiCTR2000031194, registered on 23/03/2020).
CI  - (c) 2023. The Author(s).
FAU - Xiang, Xueli
AU  - Xiang X
AD  - Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education 
      Key Laboratory of Child Development and Disorders, Children's Nutrition Research 
      Center, National Clinical Research Center for Child Health and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing, China.
FAU - Yang, Ting
AU  - Yang T
AD  - Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education 
      Key Laboratory of Child Development and Disorders, Children's Nutrition Research 
      Center, National Clinical Research Center for Child Health and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education 
      Key Laboratory of Child Development and Disorders, Children's Nutrition Research 
      Center, National Clinical Research Center for Child Health and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing, China.
FAU - Chen, Li
AU  - Chen L
AD  - Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education 
      Key Laboratory of Child Development and Disorders, Children's Nutrition Research 
      Center, National Clinical Research Center for Child Health and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing, China.
FAU - Dai, Ying
AU  - Dai Y
AD  - Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education 
      Key Laboratory of Child Development and Disorders, Children's Nutrition Research 
      Center, National Clinical Research Center for Child Health and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Xi'an Children's Hospital, Xi'an, China.
FAU - Li, Ling
AU  - Li L
AD  - Department of Children Rehabilitation, Hainan Women and Children's Medical 
      Center, Haikou, China.
FAU - Jia, Feiyong
AU  - Jia F
AD  - Department of Developmental and Behavioral Pediatric, The First Hospital of Jilin 
      University, Changchun, China.
FAU - Wu, Lijie
AU  - Wu L
AD  - Department of Children's and Adolescent Health, Public Health College of Harbin 
      Medical University, Harbin, China.
FAU - Hao, Yan
AU  - Hao Y
AD  - Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Ke, Xiaoyan
AU  - Ke X
AD  - Child Mental Health Research Center of Nanjing Brain Hospital, Nanjing, China.
FAU - Yi, Mingji
AU  - Yi M
AD  - Department of Child Health Care, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Hong, Qi
AU  - Hong Q
AD  - Maternal and Child Health Hospital of Baoan, Shenzhen, China.
FAU - Chen, Jinjin
AU  - Chen J
AD  - Department of Child Healthcare, Shanghai Children's Hospital, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Fang, Shuanfeng
AU  - Fang S
AD  - Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
FAU - Wang, Yichao
AU  - Wang Y
AD  - NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial 
      Maternal and Child Health Care Hospital, Changsha, China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Deyang Maternity & Child Healthcare Hospital, Deyang, China.
FAU - Jin, Chunhua
AU  - Jin C
AD  - Department of Children Health Care, Capital Institute of Pediatrics, Beijing, 
      China.
FAU - Li, Tingyu
AU  - Li T
AD  - Chongqing Key Laboratory of Childhood Nutrition and Health, Ministry of Education 
      Key Laboratory of Child Development and Disorders, Children's Nutrition Research 
      Center, National Clinical Research Center for Child Health and Disorders, 
      Children's Hospital of Chongqing Medical University, Chongqing, China. 
      tyli@vip.sina.com.
LA  - eng
SI  - ChiCTR/ChiCTR2000031194
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20230316
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (R2016)
SB  - IM
MH  - Child
MH  - Humans
MH  - Infant
MH  - *Autism Spectrum Disorder/psychology
MH  - *Autistic Disorder/complications
MH  - Dietary Supplements
MH  - Feeding Behavior
PMC - PMC10022051
OTO - NOTNLM
OT  - Autism spectrum disorder
OT  - Feeding patterns
OT  - Multicenter survey
OT  - Neurodevelopment
OT  - Symptoms
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/03/18 06:00
MHDA- 2023/03/21 06:00
PMCR- 2023/03/16
CRDT- 2023/03/17 08:23
PHST- 2022/10/20 00:00 [received]
PHST- 2023/03/08 00:00 [accepted]
PHST- 2023/03/17 08:23 [entrez]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/03/16 00:00 [pmc-release]
AID - 10.1186/s12888-023-04667-2 [pii]
AID - 4667 [pii]
AID - 10.1186/s12888-023-04667-2 [doi]
PST - epublish
SO  - BMC Psychiatry. 2023 Mar 16;23(1):174. doi: 10.1186/s12888-023-04667-2.