PMID- 36928480
OWN - NLM
STAT- MEDLINE
DCOM- 20230616
LR  - 20230621
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 33
IP  - 12
DP  - 2023 Jun 8
TI  - Altered structural connectome of children with auditory processing disorder: a 
      diffusion MRI study.
PG  - 7727-7740
LID - 10.1093/cercor/bhad075 [doi]
AB  - Auditory processing disorder (APD) is a listening impairment that some 
      school-aged children may experience despite having normal peripheral hearing. 
      Recent resting-state functional magnetic resonance imaging (MRI) has revealed an 
      alteration in regional functional brain topology in children with APD. However, 
      little is known about the structural organization in APD. We used diffusion MRI 
      data to investigate the structural connectome of 58 children from 8 to 14 years 
      old diagnosed with APD (n = 29) and children without hearing complaints (healthy 
      controls, HC; n = 29). We investigated the rich-club organization and structural 
      connection differences between groups. The APD group showed similar rich-club 
      organization and edge-wise connection compared with the HC group. However, at the 
      regional level, we observed increased average path length (APL) and betweenness 
      centrality in the right inferior parietal lobule and inferior precentral gyrus, 
      respectively, in the APD group. Only HCs demonstrated a positive association 
      between APL and the listening-in-spatialized-noise-sentences task in the left 
      orbital gyrus. In line with previous findings, the current results provide 
      evidence for altered structural networks at the regional level in the APD group, 
      suggesting the involvement of multimodal deficits and a role for 
      structure-function alteration in the listening difficulties of children with APD.
CI  - (c) The Author(s) 2023. Published by Oxford University Press.
FAU - Alvand, Ashkan
AU  - Alvand A
AUID- ORCID: 0000-0002-2809-0613
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      central, Auckland 1010, New Zealand.
AD  - Eisdell Moore Centre, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
FAU - Kuruvilla-Mathew, Abin
AU  - Kuruvilla-Mathew A
AUID- ORCID: 0000-0002-9025-2900
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      central, Auckland 1010, New Zealand.
AD  - Eisdell Moore Centre, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
FAU - Roberts, Reece P
AU  - Roberts RP
AUID- ORCID: 0000-0001-6760-0981
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      central, Auckland 1010, New Zealand.
AD  - Centre for Brain Research, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
FAU - Pedersen, Mangor
AU  - Pedersen M
AUID- ORCID: 0000-0002-9199-1916
AD  - School of Psychology and Neuroscience, Auckland University of Technology, 
      Auckland central, Auckland 0627, New Zealand.
FAU - Kirk, Ian J
AU  - Kirk IJ
AUID- ORCID: 0000-0002-0444-6718
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      central, Auckland 1010, New Zealand.
AD  - Eisdell Moore Centre, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
AD  - Centre for Brain Research, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
FAU - Purdy, Suzanne C
AU  - Purdy SC
AUID- ORCID: 0000-0001-9978-8173
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      central, Auckland 1010, New Zealand.
AD  - Eisdell Moore Centre, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
AD  - Centre for Brain Research, The University of Auckland, Auckland central, Auckland 
      1023, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - *Auditory Perceptual Disorders/diagnostic imaging/pathology
MH  - *Connectome
MH  - Brain
MH  - Auditory Perception
MH  - Diffusion Magnetic Resonance Imaging
PMC - PMC10267651
OTO - NOTNLM
OT  - auditory processing disorder
OT  - diffusion MRI
OT  - graph theory
OT  - rich-club
OT  - structural connectivity
EDAT- 2023/03/18 06:00
MHDA- 2023/06/16 06:42
PMCR- 2023/03/16
CRDT- 2023/03/17 09:12
PHST- 2022/11/21 00:00 [received]
PHST- 2023/02/20 00:00 [revised]
PHST- 2023/02/21 00:00 [accepted]
PHST- 2023/06/16 06:42 [medline]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/17 09:12 [entrez]
PHST- 2023/03/16 00:00 [pmc-release]
AID - 7078817 [pii]
AID - bhad075 [pii]
AID - 10.1093/cercor/bhad075 [doi]
PST - ppublish
SO  - Cereb Cortex. 2023 Jun 8;33(12):7727-7740. doi: 10.1093/cercor/bhad075.