PMID- 36930056
OWN - NLM
STAT- MEDLINE
DCOM- 20230407
LR  - 20230420
IS  - 1473-6519 (Electronic)
IS  - 1363-1950 (Linking)
VI  - 26
IP  - 3
DP  - 2023 May 1
TI  - Microbiota and growth among infants and children in low-income and middle-income 
      settings.
PG  - 245-252
LID - 10.1097/MCO.0000000000000927 [doi]
AB  - PURPOSE OF REVIEW: Adequate nutrition is essential but insufficient for optimal 
      childhood growth and development. Increasingly, it is clear that the gut 
      microbiota modulates childhood growth and may be particularly important in 
      low-income and middle-income countries (LMIC), where growth faltering, 
      undernutrition, environmental contamination and enteric pathogens are more 
      common. We summarize recent evidence demonstrating the role of the gut microbiota 
      in impacting childhood growth and interventions targeting the gut microbiota to 
      impact growth in children in LMIC settings. RECENT FINDINGS: Recent studies show 
      that maturation of the infant microbiota is linked with the development of the 
      immune system, which is key to host-microbe symbiosis. Infants lacking 
      Bifidobacterium longum subsp. Infantis , which predominates breastfed microbiome, 
      display immune activation while supplementation is linked to increased immune 
      tolerance and among undernourished children, promotes growth. Microbiome-directed 
      complimentary foods (MDCF) containing local ingredients is a novel strategy to 
      promote gut microbiota development, especially among undernourished children and 
      improve growth. Dietary patterns during pregnancy may drive selection of gut 
      microbial species that impact infant health and growth. SUMMARY: Growth patterns 
      among children in LMIC settings are closely associated with the diversity and 
      maturity of the infant microbiome. Prebiotics, probiotics, and synbiotics 
      targeting microbiota dysbiosis may impact birth outcomes, infant immune 
      development and infections, and childhood growth in LMIC settings.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Njunge, James M
AU  - Njunge JM
AD  - KEMRI-Wellcome Trust Research Programme, Kilifi.
AD  - The Childhood Acute Illness & Nutrition Network, Nairobi, Kenya.
FAU - Walson, Judd L
AU  - Walson JL
AD  - The Childhood Acute Illness & Nutrition Network, Nairobi, Kenya.
AD  - Department of Global Health.
AD  - Departments of Medicine, Pediatrics, and Epidemiology, University of Washington, 
      Seattle, Washington, USA.
LA  - eng
GR  - 222967/B/21/Z/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230303
PL  - England
TA  - Curr Opin Clin Nutr Metab Care
JT  - Current opinion in clinical nutrition and metabolic care
JID - 9804399
RN  - 0 (Prebiotics)
SB  - IM
MH  - Pregnancy
MH  - Female
MH  - Infant
MH  - Child
MH  - Humans
MH  - *Probiotics
MH  - *Microbiota
MH  - Prebiotics
MH  - Breast Feeding
MH  - *Gastrointestinal Microbiome/physiology
EDAT- 2023/03/18 06:00
MHDA- 2023/04/07 06:41
CRDT- 2023/03/17 11:22
PHST- 2023/04/07 06:41 [medline]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/17 11:22 [entrez]
AID - 00075197-202305000-00008 [pii]
AID - 10.1097/MCO.0000000000000927 [doi]
PST - ppublish
SO  - Curr Opin Clin Nutr Metab Care. 2023 May 1;26(3):245-252. doi: 
      10.1097/MCO.0000000000000927. Epub 2023 Mar 3.