PMID- 36930311
OWN - NLM
STAT- MEDLINE
DCOM- 20230425
LR  - 20230425
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 19
DP  - 2023 Apr
TI  - Associations between exposure to a mixture of phenols and sex steroid hormones 
      among pre- and postmenopausal women: evidence from NHANES 2015-2016.
PG  - 57103-57113
LID - 10.1007/s11356-023-26421-7 [doi]
AB  - Environmental phenols are well known as emerging endocrine-disrupting chemicals; 
      however, their impacts on sex hormone homeostasis among pre- and postmenopausal 
      women remain unknown. Our objective was to evaluate independent and combined 
      relationships between phenol levels in urine and sex steroid hormones among 323 
      premenopausal women and 263 postmenopausal women from National Health and 
      Nutrition Examination Survey (NHANES) 2015-2016. A total of 10 phenol 
      concentrations in urine were quantified using liquid chromatography-tandem mass 
      spectrometry (LC-MS/MS). Serum concentrations of estradiol and total testosterone 
      were measured by LC-MS/MS and serum sex hormone-binding globulin (SHBG) 
      concentrations were measured using an immunofluorometric assay. Multivariable 
      linear regression models were conducted to explore associations of individual 
      phenol concentration in urine with natural logarithm-transformed serum hormone 
      levels. Bayesian kernel machine regression (BKMR) model was conducted to evaluate 
      phenol mixtures exposure in association with sex hormones among pre- and 
      postmenopausal women, respectively. Considering both single-chemical models and 
      multiple-chemical models, each doubling of urinary BPS concentration was 
      significantly inversely related to serum SHBG concentration in premenopausal 
      women (percent change: -6.70%, 95% confidence interval, CI: -11.12%, -2.73%; P = 
      0.002). Moreover, every doubling of urinary BP-3 concentration was significantly 
      positively associated with SHBG level in serum (percent change: 3.53%, 95%CI: 
      0.70%, 5.70%; P = 0.008). Regarding postmenopausal women, inverse associations 
      between urinary BPS levels and serum estradiol concentrations were observed 
      (percent change: -8.62%, 95% CI: -15.33%, -2.06%; P = 0.012). The results 
      revealed that BPS and BP-3 exposure may adversely disrupt sex hormone homeostasis 
      at the current exposure levels among women in the USA. The findings and their 
      underlying mechanisms are warranted to be confirmed and comprehensively 
      interpreted in further epidemiological and experimental studies.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Guo, Menglu
AU  - Guo M
AD  - Department of Medical Records and Statistics, Shanghai Sixth People's Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, 
      Xuhui, Shanghai, China.
FAU - Zhu, Changlin
AU  - Zhu C
AD  - Department of Medical Records and Statistics, Shanghai Sixth People's Hospital 
      Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, 
      Xuhui, Shanghai, China. clzhu02@outlook.com.
LA  - eng
PT  - Journal Article
DEP - 20230317
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Phenols)
RN  - 339NCG44TV (Phenol)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 4TI98Z838E (Estradiol)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Humans
MH  - Female
MH  - Nutrition Surveys
MH  - *Postmenopause
MH  - *Phenols/urine
MH  - Phenol
MH  - Chromatography, Liquid
MH  - Bayes Theorem
MH  - Tandem Mass Spectrometry
MH  - Gonadal Steroid Hormones
MH  - Estradiol
MH  - Testosterone
OTO - NOTNLM
OT  - NHANES
OT  - Parabens
OT  - Phenols
OT  - Postmenopausal women
OT  - Premenopausal women
OT  - Sex steroid hormones
EDAT- 2023/03/18 06:00
MHDA- 2023/04/25 06:42
CRDT- 2023/03/17 12:16
PHST- 2022/11/11 00:00 [received]
PHST- 2023/03/08 00:00 [accepted]
PHST- 2023/04/25 06:42 [medline]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/17 12:16 [entrez]
AID - 10.1007/s11356-023-26421-7 [pii]
AID - 10.1007/s11356-023-26421-7 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Apr;30(19):57103-57113. doi: 
      10.1007/s11356-023-26421-7. Epub 2023 Mar 17.