PMID- 36930522
OWN - NLM
STAT- MEDLINE
DCOM- 20230607
LR  - 20230608
IS  - 1475-1313 (Electronic)
IS  - 0275-5408 (Linking)
VI  - 43
IP  - 4
DP  - 2023 Jul
TI  - Normative data for macular and retinal nerve fibre layer thickness in healthy 
      German children and adolescents using optical coherence tomography.
PG  - 922-934
LID - 10.1111/opo.13123 [doi]
AB  - PURPOSE: To establish normative data for macular thickness, macular volume and 
      peripapillary retinal nerve fibre layer (RNFL) thickness using Spectralis(R) 
      spectral-domain optical coherence tomography (SD-OCT) in healthy German children 
      and adolescents and investigate influencing factors. METHODS: The cross-sectional 
      study included the right eye of 695 children with at least one complete retinal 
      OCT scan. As part of the LIFE Child study, the children underwent an 
      ophthalmological examination including axial length (AL), spherical equivalent 
      (SE) and OCT measurements. Various questionnaires were answered by the children 
      or their parents to identify media use or outdoor time. Multiple linear 
      regression models were used to investigate the potential influencing factors. 
      RESULTS: A total of 342 boys and 353 girls with an average age (SD) of 12.91 
      (3.29) years participated. The mean AL (SD) was 23.20 (0.86) mm. The mean macular 
      thickness (SD) was 320.53 (12.29) mum and the mean RNFL thickness (SD) was 102.88 
      (8.79) mum. Statistical analysis revealed a significant correlation between 
      average macular thickness and age (p < 0.001, beta = 0.77) as well as AL (p < 0.001, 
      beta = -4.06). In addition, boys had thicker maculae (p < 0.001, beta = 5.36). The RNFL 
      thickness showed no significant correlation with children's age (p > 0.05), but 
      with AL (p = 0.002, beta = -2.15), birth weight (p = 0.02, beta = 0.003) and a 
      gender-specific effect of the body mass index standard deviation score for male 
      participants (p = 0.02, beta = 1.93). CONCLUSION: This study provides normative data 
      and correlations between macular and RNFL thickness in healthy German children. 
      Especially age, gender and AL must be taken into account when evaluating 
      quantitative OCT measurements to classify them as normal.
CI  - (c) 2023 The Authors. Ophthalmic and Physiological Optics published by John Wiley & 
      Sons Ltd on behalf of College of Optometrists.
FAU - Sohnel, Tanja
AU  - Sohnel T
AUID- ORCID: 0000-0003-4021-142X
AD  - LIFE Leipzig Research Center for Civilization, Leipzig University, Leipzig, 
      Germany.
FAU - Meigen, Christof
AU  - Meigen C
AD  - LIFE Leipzig Research Center for Civilization, Leipzig University, Leipzig, 
      Germany.
FAU - Hiemisch, Andreas
AU  - Hiemisch A
AD  - LIFE Leipzig Research Center for Civilization, Leipzig University, Leipzig, 
      Germany.
AD  - Department of Women and Child Health Leipzig, Leipzig University Hospital for 
      Children and Adolescents, Leipzig, Germany.
FAU - Wahl, Siegfried
AU  - Wahl S
AD  - Institute for Ophthalmic Research, Eberhard Karls University Tubingen, Tubingen, 
      Germany.
AD  - Carl Zeiss Vision International GmbH, Aalen, Germany.
FAU - Ziemssen, Focke
AU  - Ziemssen F
AD  - Department of Ophthalmology, University Hospital Leipzig, Leipzig, Germany.
FAU - Truckenbrod, Carolin
AU  - Truckenbrod C
AUID- ORCID: 0000-0002-4187-1860
AD  - LIFE Leipzig Research Center for Civilization, Leipzig University, Leipzig, 
      Germany.
FAU - Hubner, Katharina
AU  - Hubner K
AD  - LIFE Leipzig Research Center for Civilization, Leipzig University, Leipzig, 
      Germany.
FAU - Kiess, Wieland
AU  - Kiess W
AD  - LIFE Leipzig Research Center for Civilization, Leipzig University, Leipzig, 
      Germany.
AD  - Department of Women and Child Health Leipzig, Leipzig University Hospital for 
      Children and Adolescents, Leipzig, Germany.
AD  - Center for Pediatric Research, Leipzig University, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230317
PL  - England
TA  - Ophthalmic Physiol Opt
JT  - Ophthalmic & physiological optics : the journal of the British College of 
      Ophthalmic Opticians (Optometrists)
JID - 8208839
SB  - IM
MH  - Female
MH  - Humans
MH  - Child
MH  - Male
MH  - Adolescent
MH  - *Tomography, Optical Coherence/methods
MH  - *Retinal Ganglion Cells
MH  - Cross-Sectional Studies
MH  - Nerve Fibers
MH  - Reference Values
OTO - NOTNLM
OT  - RNFL thickness
OT  - epidemiology
OT  - healthy children
OT  - macular thickness
OT  - normative data
OT  - optical coherence tomography
EDAT- 2023/03/18 06:00
MHDA- 2023/06/07 06:42
CRDT- 2023/03/17 12:32
PHST- 2023/02/25 00:00 [revised]
PHST- 2022/10/10 00:00 [received]
PHST- 2023/02/28 00:00 [accepted]
PHST- 2023/06/07 06:42 [medline]
PHST- 2023/03/18 06:00 [pubmed]
PHST- 2023/03/17 12:32 [entrez]
AID - 10.1111/opo.13123 [doi]
PST - ppublish
SO  - Ophthalmic Physiol Opt. 2023 Jul;43(4):922-934. doi: 10.1111/opo.13123. Epub 2023 
      Mar 17.